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Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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The efficacy of aerobic exercise combined with sertraline in the treatment of elderly patients with post-stroke depression, and its effect on cognitive function and inflammatory cytokine
ZHU Laiyun, WANG Nuan, SUN Lingchen, ZHAO Chao
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202508024
Abstract(176) HTML(68) PDF (1074KB)(2)
Abstract:
  Objective  To investigate the efficacy of aerobic exercise combined with sertraline in the treatment of post-stroke depression （PSD） in elderly patients and its effects on cognitive function and inflammatory cytokines.   Methods  70 elderly PSD patients admitted to the Xuzhou Municipal Hospital affiliated with Xuzhou Medical University from June 2022 to December 2024 were selected as study objects. Patients were randomly divided into control group treated with sertraline and study group treated with aerobic exercise combined with sertraline. The treatment duration was 8 weeks. The Hamilton Depression Rating Scale （HAMD） scores, the clinical efficacy, cognitive function [Mini Mental State Examination （MMSE）], and the levels of inflammatory cytokines （IL-1β, IL-6, TNF-α） were compared before and after treatment.   Results  No significant differences in baseline data were observed between the two groups before treatment. After 4 and 8 weeks of treatment, HAMD scores were significantly decreased compared to baseline in both groups （all P<0.05）. The study group showed significantly lower HAMD scores than the control group at both 4 and 8 weeks （all P<0.05）. The overall clinical effective rate was significantly higher in the study group （94.29%） than in the control group （77.14%）（P<0.05）. MMSE scores were significantly increased compared to baseline in both groups at 4 and 8 weeks（all P<0.05）, and the study group demonstrated significantly higher MMSE scores than the control group at both time points （all P<0.05）. Similarly, serum levels of IL-1β, IL-6, and TNF-α were significantly reduced from baseline in both groups at 4 and 8 weeks （all P<0.05）. The reductions in these inflammatory cytokine levels were significantly greater in the study group compared to the control group （all P<0.05）. The incidence of adverse reactions was 8.57% in the control group and 5.71% in the study group, with no statistically significant difference （P>0.05）.   Conclusion  The combination of aerobic exercise and sertraline is a safe and reliable therapeutic strategy for elderly PSD patients, alleviating depressive symptoms, improving cognitive function, and reducing systemic inflammation.
Herbal textual research on food and medicinal homologous of Kui
PAN Qian, MENG Xiangqing, SONG Yitong, WU Tianmengda, JIA Dan, JIA Min
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202403020
Abstract(480) HTML(173) PDF (1697KB)(6)
Abstract:
Kui was first recorded in Rites of the Zhou and is the earliest domesticated wild vegetable in China. In the Qi Min Yao Shu, Kui was called “the master of all vegetables” and has a long history of application in China. As a medicine, Kuizi was first recorded in Shen Nong’s Herbal Classic, which has a history of more than 2,000 years of medicinal use and a long history of clinical application. By consulting the ancient and modern herbal literature, the first herbs texts of Kui were examined, various recorded texts, confused products and the history of the original medicinal use were clarified. It was concluded that the ancient herbal texts recorded the base plant of Kui as Malva verticillata L. belonging to family Malvaceae, which provided scientific basis for the development and utilization of Kui.
Construction of Glucose Oxidase–Loaded Nanogels and Its Inhibition Effect on the Warburg Effect in Glioma Cells
ZHOU Wenbo, LI Weilin, DAI Wuting, LIU Reiyao, YU Yuan
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202511030
Abstract(363) HTML(117) PDF (2481KB)(3)
Abstract:
  Objective  To construct glucose oxidase–loaded nanogels （GONGs）, optimize their formulation, and evaluate their capacity to inhibit the Warburg effect in glioma cells.   Methods  A responsive polymer （HAM） was synthesized and used to self-assemble GONGs, which were then characterized. Encapsulation efficiency and drug loading were determined using fluorescence spectrophotometry. Biocompatibility was tested by measuring cytotoxicity and hemolytic activity. Western blotting was used to evaluate the effects of GONGs on the expression of proteins associated with the Warburg phenotype and oxidative damage in glioma cells.   Results  GONGs prepared at a drug-to-polymer ratio of 1∶10 exhibited a particle size of 140.3 nm and a zeta potential of −27.2 mV. Compared with free GOx, GONGs markedly reduced cytotoxicity, increasing the IC50 in hUVEC cells from 2.150 nmol/L to 74.86 nmol/L, and significantly decreased hemolysis. At a GOx concentration of 2 nmol/L, GONGs effectively downregulated glycolysis-related proteins, such as HK2 and LDHA, and inhibited glutamine metabolism in glioma cells.   Conclusion  GONGs exhibited high GOx loading capacity, significantly reduced GOx-induced cytotoxicity, inhibited the Warburg effect in glioma cells and induced oxidative damage.
Application of Raman spectroscopy to study the quality of dermal drug administration and transdermal in vitro
CUI Yingxin, WEI Jingjing, YE Xiaoxia, LE Jian
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202409017
Abstract(2446) HTML(485) PDF (1742KB)(28)
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Percutaneous administration is safety, convenience and high compliance. However, the skin structure is complex and individual differences are large, especially the barrier of the stratum corneum leads to the poor bioavailability of topical preparations for the skin. The composition of the prescription for dermal drug administration is complicated, and the quality of the product should be strictly controlled. Raman spectroscopy, as a non-destructive vibrational spectrum can be used to characterize key quality properties of dermal drug administration combined with stoichiometric methods, imaging techniques and other spectral techniques. The purpose of this paper is to review the application of Raman spectroscopy in the study of crystal form, particle size distribution, excipients and in vitro transdermal experiments of dermal drug administration. In vitro transdermal tests, Raman spectroscopy was used to distinguish skin of different species, study the spatial distribution of drugs in skin and the interaction between drugs and skin
Efficacy and safety comparison of EGFR-TKIs monotherapy and combination therapy as first-line treatment for advanced non-small cell lung cancer: a network meta-analysis
CHEN Guanxu, SONG Yutong, GUO Xiuqiang, ZHANG Mi, LIU Zhihong, SONG Hongtao
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202504044
Abstract(6188) HTML(2835) PDF (3982KB)(26)
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  Objective  To investigate the efficacy and safety of EGFR-TKIs monotherapy and its combination therapy in the first-line treatment of advanced non-small cell lung cancer（NSCLC）patients with EGFR mutations.   Methods  Databases such as PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were systematically searched to collect eligible phase II/III randomized controlled trials （RCTs）, with the time range from the establishment of the databases to June 2023. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the studies. Outcome data, including overall survival （OS）, progression-free survival （PFS）, objective response rate （ORR）, grade 3 or higher adverse events （≥3 AEs）, and serious adverse events （SAEs）, were collected. A network meta-analysis was performed using R software （version 4.2.1） under the Bayesian theoretical framework. Subgroup analyses of survival outcomes （OS, PFS） were conducted based on different clinical and pathophysiological characteristics of the patients.   Results  A total of t wenty-eight phase II/III RCTs were included in the study, involving a total of 7 460 patients and 18 first-line treatment regimens. The results showed that in terms of efficacy, gefitinib + pemetrexed-containing chemotherapy performed best in OS and ORR, while osimertinib + bevacizumab performed best in PFS. In terms of safety, furmonertinib had the lowest incidence of ≥3 grade AEs, and osimertinib had the lowest incidence of SAEs. Subgroup analysis results indicated that the efficacy and safety of various treatment regimens differed among patients with different clinical and pathological characteristics.   Conclusion  Monotherapy with third-generation EGFR-TKIs, represented by osimertinib, serves as the preferred therapeutic option considering both efficacy and safety profiles. While some combination therapies can enhance survival benefits, but need to be vigilant about increased toxicity. Clinical decision-making should be tailored based on patient' mutation subtypes, comorbidities, and tolerance.
Optimizing the whole-process quality control system of intravenous drug distribution center based on failure mode and effect analysis
WEI Wei, ZHANG Mingxia, ZHOU Yanping, YAN Lan, TIAN Peng, FENG Xia
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202504131
Abstract(3068) HTML(866) PDF (1030KB)(17)
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  Objective  To explore the application effect of a standardized management method based on Failure Mode and Effect Analysis （FMEA） in optimizing the whole-process quality control system of the Intravenous Admixture Service （PIVAS）.   Methods  The quality control management system of the IVAS was optimized by establishing six quality control groups led by the head nurse, with full participation of pharmacy, nursing, and logistical staff, ensuring comprehensive coverage and traceability of all quality control links. Each group conducted Risk Priority Number （RPN） scoring for potential failure modes in their respective quality control processes, and targeted improvement measures were formulated based on the scoring results. The RPN values of failure modes and quality control-related evaluation indicators before and after implementation were compared to achieve closed-loop management.   Results  After one year of management, the RPN values of the six major failure modes significantly decreased compared to those before implementation （P<0.05）. The compounding error rate dropped to 0.13%, the dispensing error rate decreased to 0.95%, the compounding efficiency increased to 98%, the delivery time was shortened by 0.45 hours per batch, the intervention rate for irrational prescriptions rose to 94.87%, satisfaction improved to 96.78%, and the participation rate of quality control personnel reached 95.36% （P<0.05）.   Conclusion  FMEA-based identification of potential failure modes in the whole-process quality control system of the IVAS, combined with risk quantification and targeted interventions, significantly reduces high-risk failure modes, improves compounding accuracy and efficiency, and ensures the safety of clinical intravenous medication and the effectiveness of healthcare quality management.
The hypolipidemic function and hepatic protective effects of Xuetong capsules
HE Lin, CHENG Yanqiong, YE Kanti, ZHAO Juanjuan, LU Huilan, YANG Jun, CHEN Fangjian
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202502015
Abstract(6189) HTML(2051) PDF (1288KB)(40)
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  Objective  To investigate the effects of Xuetong capsule on blood lipids and liver lesion in hyperlipidemic model animals.   Method  Sixty ICR mice were randomly divided into six groups. The normal control group was fed with normal diet, the other groups were fed with high-fat diet to induce hyperlipidemia. After four weeks feeding, the three groups were given low, middle, and high doses of Xuetong capsules （0.5, 1.0, and 2.0 g/kg ） by Gavage, and the positive control drug atorvastatin calcium （1.5 mg/kg）. The model group was given solvent （0.5% carboxymethyl cellulose sodium）. After treatment for 8 weeks, the body weight, organ index, blood lipids, blood glucose and liver function index were measured. The liver oil red staining was used to determine the lipid droplet content, and quantitative PCR was used to detect the expression of inflammatory factors TNF-α, IL-6, and IL-1β.   Result  The body weight, the weight of liver and spleen were significantly increased by high-fat diet. High-fat diet increased the organ indexes of the liver and spleen, the degree of liver oil red staining, and also significantly increased the levels of glucose, triglyceride （TG）, cholesterol （CHOL）, and low-density lipoprotein cholesterol （LDL-C） in serum. Compared with the model group, the level of TG has no significant change in low, middle and high doses groups. The level of CHOL in serum was reduced by Xuetong capsule with a dose dependent manner. There were significant difference between the model group and middle, high doses groups. The results of LDL-C were similar, the level of LDL-C was significantly reduced by middle and high doses groups （middle dose 0.55±0.21 mM, high dose 0.52±0.22 mM v.s. 0.81±0.29 mM in model group P<0.01）. Compared with the normal control, there was no significant difference in HDL-C levels between the high-fat model and each drug-treated group. Liver function showed that Xuetong capsules significantly reduced the degree of liver oil red staining and decreased the level of alanine aminotransferase （ALT） induced by high-fat diet. The body weight, the weight and organ indexes of liver and spleen were significantly reduced by atorvastatin calcium. The levels of CHOL, LDL-C, and TG, and the degree of liver oil red staining were also significantly reduced in atorvastatin calcium group. Further studies have shown that high dose of Xuetong capsules significantly reduced the expression of TNF-α and IL-6 induced by high-fat diet （P<0.05）, while the reduction of IL-1β was not so significant （P>0.05）.   Conclusion  Xuetong capsules significantly reduces the body weight of animals with high fat, reduce liver size, fat deposition, inflammatory damage and also significantly reduces blood lipid CHOL and LDL-C levels and reduce transaminase elevation. The above effects may be related to Xuetong capsules reducing the expression of inflammatory factors such as TNF-α and IL-6 in the liver.
Amelioration chloride-induced abdominal aortic aneurysm injury by activation of α7nAChR s calcium in mice
ZHANG Wenjing, FU Hui, GUO Xiaobin, GUO Hao
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202409045
Abstract(5164) HTML(2104) PDF (3531KB)(21)
Abstract:
  Objective  To investigate the effect of activating α7 nicotinic acetylcholine receptor （α7nAChR） on calcium chloride （CaCl2）-induced abdominal aortic aneurysm （AAA） injury in mice.   Methods  AAA model was induced by CaCl2 in wild type （WT） mice and α7nAChR knockout （α7nAChR−/-） mice. The effects of knockout of α7nAChR on histological damage in CaCl2-induced AAA mice and expression of inflammatory factors were assessed by HE staining, EVG staining and IHC staining. Rat-derived primary vascular smooth muscle cells （VSMC） were stimulated with TNF-α, which mimicked the inflammatory environment of AAA. The expressions of inflammation-related proteins were detected by using Western-Blot with or without PNU-282987 to activate α7nAChR.   Results  Aortic dilatation was obvious, and the aortic structure was disrupted in CaCl2-induced AAA mice. Knockout of α7nAChR further exacerbated the histological injury and significantly up-regulated the expression of inflammation-related proteins in aorta of AAA mice. It was showed that TNF-α stimulation of VSMC increased inflammation-related protein expression, whereas activation of α7nAChR prevented the phenomenon.   Conclusion  Activation of α7nAChR could attenuate CaCl2-induced AAA injury in mice by suppressing the inflammatory response.
Practice and analysis of the simplified oral premedication protocol with paclitaxel liposome in patients of advanced gastric cancer
ZHONG Ling, CAO Jinfa, HE Miao, TIAN Jing
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202406047
Abstract(5033) HTML(1650) PDF (837KB)(14)
Abstract:
[ Abstract ]  Objective  To explore a feasible simplified premedication protocol for preventing hypersensitivity reactions to taxanes.   Methods  The electronic medical record system was used to search for data on 49 patients with advanced gastric cancer who received paclitaxel liposome treatment for the first time in the gastroenterology department of our hospital from 2021-06-01 to 2024-06-30, including premedication protocols, allergic reactions, and other adverse reactions.   Results  31 cases took dexamethasone 9 mg at 12-hour and 6-hour, and took loratadine tablets 10 mg and ranitidine hydrochloride capsules 150 mg at 12-hour before paclitaxel liposomal; 18 cases took dexamethasone 9 mg at 12-hour and 6-hour, and took loratadine tablets 10 mg at 12-hour before paclitaxel liposomal. All patients did not experience any allergic reactions. There were no significant differences in the incidence of other adverse reactions between the two simplified protocols（P>0.05）. Conclusion Based on literature and practice, a dual simplified premedication protocol of oral corticosteroids（GC）combined with oral H1 receptor blockers（H1RA）was proposed, which provided a new idea for doctors. Further clinical studies are needed to verify its effectiveness.
Analysis of the hotspots and advantages of adverse drug reaction automatic monitoring system based on CiteSpace and systematic review
WANG Yan, KANG Le, CHEN Wen, FANG Qi, YU Zhongwang, CAO Li
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202501034
Abstract(4776) HTML(797) PDF (1309KB)(20)
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  Objective  To provide a reference for the establishment, development and application of the adverse drug reaction （ADR） automated monitoring system, through verifying and quantifying the research hotspots and advantages of the system by CiteSpace software and systematic review.   Methods  Literature on ADR automated monitoring up to December 2023 were retrieved and screened from CNKI and web of science databases. CiteSpace 6.4.R1 software was used to conduct co-occurrence, clustering and emergence analysis, and to visualize and comparatively analyze the research hotspots, rules and distribution in the field of automated monitoring of ADR at home and abroad. In compliance with the preferred reporting items for systematic reviews and Meta-analyses （PRISMA）, literature covering publications in English and Chinese including detection rates of ADRs collected using Incident Reporting Systems （IRSs） and/or automated monitoring systems were retrieved and screened. The advantages and disadvantages of automated monitoring systems were analyzed by comparing the differences between these two systems in terms of the number of ADR reports and the types of positive signals.   Results  A total of 56 articles in English and 80 articles in Chinese were indexed by CiteSpace. The research hotspots in recent years included data mining, deep learning, text classification techniques, machine learning and so on. A total of seven studies compiled with the inclusion criteria for the systematic evaluation, all of which were completed between 1991 and 2021 in hospitals in four countries. 150 526 medical records were reviewed from 15 institutions. A total of 194 ADR reports were collected by IRSs. A total of 2 090 ADR reports were collected by the automated monitoring system over the same period, indicating a 977% increase in the number of ADR reports （P=0.0156） compared with the IRSs.   Conclusion  The ADR automatic monitoring system had significantly improved the level of drug risk identification and reduced costs, but it was necessary to optimize the algorithm, expand the data source and carry out standardization construction to overcome the current limitations.
Effect of remimazolam premedication on emergence delirium in children undergoing tonsillectomy and （or）adenoidectomy
WANG Fei, ZHANG Rui, XU Yong, CHEN Xian, ZHU Yumin
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202411036
Abstract(3012) HTML(599) PDF (853KB)(12)
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  Objective   To evaluate the effect of remimazolam premedication on emergence delirium （ED） in children undergoing tonsillectomy and （or） adenoidectomy.   Methods  Children aged 3-6 years who underwent tonsillectomy and （or） adenoidectomy with general anesthesia in Zhongshan Hospital Affiliated to Xiamen University from July 2023 to September 2024 were randomly divided into group 0.1 mg/kg remimazolam （group R1）, group 0.2 mg/kg remimazolam （group R2） and normal saline group （group P）. Three groups were sedated preoperatively with remimazolam 0.1 mg/kg, remimazolam 0.2 mg/kg and normal saline, respectively. The primary outcome was the incidence of ED. The secondary outcomes included the parental separation anxiety scale （PSAS） score when entering the operating room, the induction compliance checklist （ICC） score at induction, the anesthetic recovery time, the incidence of rescue propofol for ED, the face, legs, activity, cry, and consolability （FLACC） score and the incidence of postoperative pain during the recovery period, the incidence of adverse reactions during the operation and postoperatively, and the incidence of negative postoperative behavioral changes （NPOBCs） at 1 day, 7 days, and 30 days postoperatively.   Results  A total of 119 children completed the study, including 41 in group R1, 38 in group R2, and 40 in group P. The incidence of ED and propofol rescue, the PSAS scores and ICC scores of group R1 and R2 were lower than that of group P （P<0.05）, and the above results in group R2 was better than those in group R1 （P<0.05）. The FLACC score, the incidence of postoperative pain, and the incidence of adverse reactions between the three groups had no difference （P>0.05）. The incidence of NPOBCs at 1 day and 7 days postoperatively of the group R1 and group R2 was lower than of the group P （P<0.05）, but no difference in that was detected at 30 days postoperatively among the three groups （P>0.05）.   Conclusion  Remimazolam used for preoperative sedation could reduce the incidence of ED in children undergoing tonsillectomy and （or） adenoidectomy, and had a positive effect on alleviating the preoperative anxiety and preventing NPOBCs
The Evolutionary Pattern of Meaning in Life Among University Students and Its Association with Depressive Symptoms
YU Yongju, HE Min
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.20240380
Abstract(4556) HTML(1354) PDF (985KB)(15)
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This study aimed to clarify the causal relationship between meaning in life and depression symptoms, explore the evolutionary patterns of meaning in life, and assess its impact on the incidence of depressive symptoms. A two-wave longitudinal study with a 12-month interval was conducted among 896 university students recruited from one university. The meaning in life questionnaire and the depression symptom screening questionnaire were administered. The findings showed that: 1）Meaning in life at T1 negatively predicted depression symptoms at T2. Conversely, depression symptoms at T1 did not significantly predict meaning in life at T2. 2）The evolutionary patterns of meaning in life from T1 to T2 could be categorized into four groups: sustained low meaning, meaning improvement, meaning reduction, and sustained high meaning. The incidence of depressive symptoms in these four groups was 13.00%, 5.00%, 12.00%, and 4.00%, respectively. 3）The evolutionary patterns of meaning in life significantly impacted the incidence of depressive symptoms. Compared to the sustained high meaning group, both the sustained low meaning group and the meaning reduction group exhibited significantly higher rates of depression symptoms. The results suggest that psychological health education in universities should focus on individuals with sustained low meaning or meaning reduction, and that enhancing meaning in life serves as an effective intervention approach to reducing the incidence of depression symptoms among university students.
Design, synthesis, and in vitro anti-inflammatory activity of novel Matrine derivatives
LU Yifei, SONG Jia, SHEN Hongxia, ZHAO Qingjie
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202503005
Abstract(6286) HTML(2718) PDF (1044KB)(40)
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  Objective  The alkaloids contained in the Chinese herb Sophora flavescens have good anti-inflammatory activity. To investigate the structure-activity relationship between the novel Matrine and the anti-inflammatory activity by modifying the structure of Matrine .   Methods  Fourteen novel Matrine derivatives were obtained by chemical modification using Matrine as the lead compound with Matrine and M19 as positive controls. The cytotoxicity of Matrine derivatives against RAW264.7 cells was detected by the Cell Counting Kit 8 （CCK8） assay, and the relative amount of Nitric Oxide （NO） produced by Matrine derivatives against Lipopolysaccharide （LPS）-induced inflammation model of RAW264.7 cells was detected using an NO assay kit. The Enzyme-Linked Immunosorbent Assay （ELISA） d was used to detect the secretion of Interleukin-6 （IL-6） and Tumor Necrosis Factor Alpha （TNF-α） by Matrine derivatives in LPS-induced inflammation model of RAW264.7 cells.   Results  The novel Matrine derivatives all exhibited lower cytotoxicity compared with M19. The NO inhibition rates of the novel Matrine derivatives were all higher than that of Matrine, and some were higher than that of M19 , with compound A12 having the highest NO inhibition rate. Compounds A11 and A12 showed higher IL-6 inhibition than the control M19 . Additionally, compound A12 had higher TNF-α inhibition than the control M19 .   Conclusion  Compound A12 inhibited the strongest inhibition of NO, IL-6 and TNF-α release and had the best anti-inflammatory activity, which provided an important lead compound for this subsequent in-depth study.
The preventive and therapeutic effects of three ethanol extracts derived from three sources of Stellera chamaejasme L., on imiquimod-induced psoriasis in mice
PENG Ying, LIU Xin, NIE Yiwen, WANG Xinhe, NIAN Hua, ZHU Jianyong
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202406029
Abstract(12182) HTML(2957) PDF (2882KB)(31)
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  Objective  To investigate the preventive and therapeutic effects of ethanol extracts derived from three sources of traditional Chinese medicine: Stellera chamaejasme L., Euphorbia fischeriana Steud., and Euphorbia kansuensis Prokh., on imiquimod （IMQ）-induced psoriasis in mice.   Methods  Thirty-six male BALB/c mice were randomly divided into the following 6 groups with 6 mice in each group: blank control, model, Stellera chamaejasme, Euphorbia fischeriana, Euphorbia kansuensis, and calcipotriol. PASI （Psoriasis Area and Severity Index） scores were used to record the changes of skin lesions in each group; HE （hematoxylin-eosin） staining was used to observe the pathological morphology of skin and measure the thickness of the epidermis. Immunohistochemistry was used to detect the expression of nuclear antigen Ki67 in the skin tissues of mice.   Results  Compared with the model group, the three kinds of ethanol extracts can reduce the PASI score, inhibit epidermal thickening, and decrease expression of Ki67 in the psoriasis mice. Among them, the therapeutic effect of Stellera chamaejasme was the most significant and it was better than the commonly used topical drug calcipotriol.   Conclusion  The ethanol extract of Stellera chamaejasme has good anti-psoriatic activity, can inhibit the abnormal proliferation of keratinocytes, can reduce the expression of Ki67, and can significantly improve psoriasis-like skin lesions.
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.
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Research progress on stem cells in the treatment of sepsis
CHEN Ting, CHEN Linlin, CHEN Zhao, ZHANG Junping, WANG Yan
2026, 44(2): 59-64, 70.   doi: 10.12206/j.issn.2097-2024.202509039
Abstract(264) HTML(89) PDF (1498KB)(2)
Abstract:
At present, the treatment of sepsis depends largely on non-specific methods, highlighting an urgent need for novel therapeutic strategies. Stem cells have garnered significant attention in the treatment of various diseases due to their unique biological properties. Stem cells enhance sepsis survival through mechanisms such as reducing bacterial burden, modulating inflammation, and ameliorating organ dysfunction. Recent studies have shown that stem cells can increase the survival rate of sepsis patients through multiple pathways such as reducing the bacterial load of the host, regulating inflammatory homeostasis, and improving multi-organ dysfunction. Their derivatives, exosomes, can also alleviate the imbalanced immune response in sepsis patients. Recent advances in stem cell-based therapies for sepsis were summarized in this paper.
Research progress on the tumor microenvironment of liver cancer
SONG Tianhao, XU Weiheng, WANG Yan, CHEN Li
2026, 44(2): 65-70.   doi: 10.12206/j.issn.2097-2024.202504126
Abstract(1038) HTML(292) PDF (899KB)(15)
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Liver cancer, one of the most common primary malignancies in humans, is a malignant tumor characterized by multifactorial induction, polygenic involvement, and intricate molecular mechanisms. This disease is characterized by its treatment challenges and poor prognosis, which are closely related to its unique tumor microenvironment composition. The tumor microenvironment of liver cancer is a dynamic ecosystem composed of heterogeneous cellular populations, soluble cytokines, and remodeled extracellular matrix. In recent years, significant progress has been made in the study of the tumor microenvironment of liver cancer, revealed an important role in the occurrence, development, and treatment of liver cancer. The key regulatory elements of the tumor microenvironment in liver cancer were systematically summarized, such as activation of hepatic stellate cells, dysfunction of immune cells, abnormalities of platelet, and remodeling of the extracellular matrix, which provided theoretical foundations for prevention and treatment strategies against liver cancer.
Original articles
Study on the flavonoids from Epimedium multiflorum T. S. Ying
MI Yonghong, ZHOU Licheng, ZHANG Shuai, LIU Runhui
2026, 44(2): 71-75.   doi: 10.12206/j.issn.2097-2024.202504135
Abstract(296) HTML(94) PDF (876KB)(4)
Abstract:
  Objective  To investigate the chemical constituents of Epimedium multiflorum T. S. Ying.   Methods  The ethanol extract of E. multiflorum was separated and purified by silica gel column chromatography, preparative thin-layer chromatography, and semi-preparative reversed-phase high-performance liquid chromatography. The structures of the compounds were identified by nuclear magnetic resonance spectroscopy and comparison with literature data.   Results  Ten compounds were isolated and purified, which structures were identified as baohuoside Ⅱ（ 1 ）, 2′′-O-rhamnosyl-icariside Ⅱ（ 2 ）, icariin（ 3 ）, epimedoside A（ 4 ）, ikarisoside B（ 5 ）, epimedin C（ 6 ）, baohuoside Ⅴ（ 7 ）, epimedin A（ 8 ）, epimedin B（ 9 ）, and ikarisoside C（ 10 ）.  Conclusion  All the isolated flavonoid compounds were obtained from E. multiflorum for the first time.
Correlation between plasma concentration of voriconazole and polymorphisms in CYP2C19, CYP2C9 and CYP3A5 genes in children
GUI Mingzhu, LI Jing, LI Zhiling
2026, 44(2): 76-79, 107.   doi: 10.12206/j.issn.2097-2024.202402020
Abstract(6089) HTML(2746) PDF (1277KB)(21)
Abstract:
  Objective  To explore the effects of CYP2C19, CYP2C9 and CYP3A5 genotypes on the plasma concentration of voriconazole in children.   Methods  Collected blood samples from 50 hospitalized children with invasive fungal infections who received intravenous voriconazole from January 2020 to December 2020. High performance liquid chromatography was used to detect the blood trough concentration of voriconazole, and the time-of-flight mass spectrometry detection system was used to detect the genotypes of CYP2C19, CYP2C9 and CYP3A5, and the effects of children’s genotyping on the plasma concentration, efficacy and adverse reactions of voriconazole were analyzed.   Results  The total effective rate of 50 children with IFI was 84% （42/50 cases） after voriconazole treatment. The incidence of adverse reactions was 20% （10/50 cases）. The measured plasma concentration of voriconazole ranged from 0.56~7.62 μg/ml. Combined with the different mutation types of CYP2C19 gene loci, three metabolic activities were produced: fast, medium and slow, and the test results showed that there were 16 cases of fast metabolism, 27 cases of intermediate metabolism and 7 cases of slow metabolism. There was a significant difference in plasma concentrations among the three groups （F=15.359, P<0.001）, and the drug concentrations in the fast metabolic group were significantly lower than those in the intermediate metabolic and slow metabolic groups. The mutations of CYP2C9 and CYP3A5 had no significant effect on the plasma concentrations of the drugs, which were （F=2.213, P=0.086 and F=0.757, P=0.475）.   Conclusion  Voriconazole had significant efficacy in the treatment of invasive fungal infections in children, and the adverse reactions were mild. CYP2C19 genotype was significantly related to the rate of drug metabolism and was an important factor affecting blood drug concentration, the detection of drug concentration and genotype of voriconazole was helpful to adjust the effective drug dose clinically and would achieve more scientific and individualized treatment.
Preliminary study on the antibacterial material basis of Coptidis Rhizoma extracts by different methods based on spectrum-effect relationship
NI Xiaoxia, CHEN Qiaoxiu, YANG Yuru, CAO Yixiang
2026, 44(2): 80-84.   doi: 10.12206/j.issn.2097-2024.202403054
Abstract(247) HTML(112) PDF (1362KB)(7)
Abstract:
  Objective  To establish the HPLC fingerprints for the different extracts from Coptidis Rhizoma, and investigate the spectrum-effect relationship between HPLC fingerprints and anti-Staphylococcus aureus activity in vitro to analyze the pharmacodynamic material basis.   Methods  Nine kinds of Coptidis Rhizoma extracts were prepared, and establish the HPLC fingerprints for them. The antibacterial rate of each extract was determined by the broth microdilution method with Staphylococcus aureus as the test bacteria. The grey relational analysis （GRA） method was used to analyze the correlation between the fingerprint data and the in vitro antibacterial test data.   Results  The HPLC fingerprints of nine kinds of Coptidis Rhizoma extracts were established, nine common characteristic fingerprint peaks were calibrated, and 5 peaks were identified by the reference substance comparison method. GRA analysis experiments showed that the correlation between nine peaks and antibacterial effect was 0.559 1~0.803 3; and the peak 3, peak 8 （palmatine hydrochloride）, peak 9 （berberine hydrochloride） were positively correlated with the inhibition of Staphylococcus aureus,while the peak 9 （berberine hydrochloride） had the strongest effect, and its correlation degree was 0.803 3.   Conclusion  The effective substance of antibacterial was preliminarily determined through the study of spectrum-effect relationship for Coptidis Rhizoma extracts,which may be the alkaloids, mostly containing hydrochloride, which provided a reference for further research on the pharmacodynamic material basis of Coptidis Rhizoma.
The efficacy of oral solution of magnesium sodium potassium sulfate in bowel preparation before colonoscopy
HUANG Xin, YANG Rujie, QIN Feng, ZHANG Shilian, WU Xin, YIN Xiaoyan
2026, 44(2): 85-87, 102.   doi: 10.12206/j.issn.2097-2024.202311049
Abstract(1464) HTML(314) PDF (1264KB)(6)
Abstract:
  Objective   To explore the efficacy and safety of oral solution of magnesium sodium potassium sulfate in bowel preparation before colonoscopy.   Methods  Patients who planned to undergo colonoscopy at the digestive department of the Ninth People’s Hospital, affiliated to School of Medicine of Shanghai Jiao Tong University from January 2023 to August 2023 were selected and eligible subjects were divided into two groups: Group A took polyethylene glycol （PEG） and Group B took oral solution of magnesium sodium potassium sulfate （OSS）. The quality, drug tolerance, and safety of intestinal preparation were evaluated. The quality of bowel preparation was evaluated by the boston bowel preparation scale （BBPS）.   Results  The right colon BBPS score of Group B was (2.39±0.82) points, which was significantly higher than of Group A (2.11±0.43) points （P<0.05）. The overall score of Group B was higher than that of Group A （P<0.05）. OSS was easier to take than PEG, with a good taste and overall sensation. Patients were willing to use OSS to clean their bowels even when they were willing to undergo another examination （P<0.05）. There was a significant difference in nausea and vomiting symptoms between the two groups （P<0.05）, and there were no significant changes in renal function and electrolytes before and after medication in the two groups of patients.   Conclusion  OSS had a higher quality of bowel cleaning and was easier for patients to accept.
Research reports
Bibliometric visualization analysis of research literature of Angelica sinensis at home and abroad from 2012 to 2022 based on CiteSpace
LIU Feifei, CHEN Liping, ZHONG Yan, WANG Rong, LI Wenbin
2026, 44(2): 88-95.   doi: 10.12206/j.issn.2097-2024.202305001
Abstract(258) HTML(77) PDF (2706KB)(2)
Abstract:
  Objective  Based on the visualization graph analysis of the research hotspots of Angelica sinensis, predict the future research trends, and provide references for the next step of Angelica sinensis research.   Methods  Chinese and English literatures on Angelica sinensis collected from CNKI, WanFang, VIP and Web of Science from 2012 to 2022 were retrieved. CiteSpace 6.1.R6 software was used to perform visualization econometrics analysis on the number of publications, authors, institutions, journals, keywords and other topics.   Results  3490 Chinese literatures and 409 English literatures were included. Visual knowledge map analysis showed that Gansu University of Chinese Medicine and Nanjing University of Chinese Medicine were the research institutions with the largest number of literature publications in Chinese and English respectively. Journals published mainly include Shizhen Traditional Chinese Medicine and Materia medica, Evidence-based Complementary and Alternative Medicine. Current research hotspots include the effects of Angelica sinensis polysaccharides, volatile oils, and ferulic acid on the hematopoietic system, chronic diseases, and cognitive impairment, as well as clinical efficacy evaluations of classic prescriptions containing Angelica sinensis and their modified formulations. The research trend was characterized by a focus on the pharmacological study of Danggui Buxue Tang,employing various experimental approaches such as network pharmacology, serum pharmacology, and metabolomics to elucidate the mechanisms of Angelica sinensis.   Conclusion  The pharmacological effects of Angelica sinensis and its compound were extensive, which should be further researched.
Medicine & Clinical
Flos Buddlejae self-heating steam eye mask combined with sodium hyaluronate eye drops in the treatment of dry eye disease
TAN Zhaodan, LI Qian, SHI Yan, HU Kangyuan, HUANG Jin
2026, 44(2): 96-102.   doi: 10.12206/j.issn.2097-2024.202509010
Abstract(622) HTML(192) PDF (1389KB)(2)
Abstract:
  Objective  To assess the clinical efficacy of sodium hyaluronate （0.3%） eye drops combined with herbal self-heating steam eye mask in the treatment of dry eye disease.   Methods  A prospective randomized controlled clinical trial was performed on 60 patients diagnosed with dry eye at the ophthalmic clinic of a Grade A, Class Ⅲ hospital in Shanghai from June 2023 to September 2024. Specifically, patients were randomly divided into control group and study group. Patients in the control group were treated with sodium hyaluronate （0.3%） eye drops for six weeks; while in the study group, patients received the eye drops combined with the herbal self-heating steam eye mask mainly containing powders of Flos Buddlejae. Subsequently, comparisons and analysis were performed before and after treatment between the two groups in the clinical symptom questionnaire score traditional Chinese medicine （TCM syndrome score）, the Chinese dry eye questionnaire score and determination of tear film fluorscein breakup time （FBUT）, and curative effect.   Results  The quality control standard of the herbal powder in the self-heating steam eye mask was established through TLC and HPLC, and good heating behavior of the herbal self-heating steam eye mask was ascertained heating temperature （43±5）℃; heating duration （≥20 min）, meeting requirements of the product quality control. After treatment for 6 weeks, FBUT was increased, while TCM syndrome score and the Chinese dry eye questionnaire score were both decreased in the study group （P<0.001）. Besides, compared with the control group, TCM syndrome score and the Chinese dry eye questionnaire score were much lower, while the FBUT were higher in the study group （P<0.001）. Moreover, the overall response rate in the study group （81.7%） was much better than that in the control group （25.9%）.   Conclusion  The combination of sodium hyaluronate （0.3%） eye drops with herbal self-heating steam eye mask could be applied to the clinical treatment of dry eye disease due to its good clinical effects on relieving dry eye symptoms.
Pharmacy administration
A survey on the operational management issues of drug clinical trials in the yangtze river delta region
WU Yougen, GU Yuting, XIA Ju, QIAN Qingqing
2026, 44(2): 103-107.   doi: 10.12206/j.issn.2097-2024.202311002
Abstract(368) HTML(129) PDF (919KB)(8)
Abstract:
  Objective  To analyze the problems in the operation and management of drug clinical trials and put forward targeted suggestion.   Methods  An electronic questionnaire survey was conducted among medical staff in about 80 hospitals in the yangtze river delta region.   Results  606 valid questionnaires were received. 71% of the respondents expressed their willingness to study and participate in drug clinical trials. There were significant differences in the cognitive demands, willingness and motivation of the respondents with different occupations and educational backgrounds about the drug clinical trial work （P<0.05）. During the operation of drug clinical trials, respondents reported the main factors affecting the quality of clinical trials which including good clinical practice (GCP) awareness and subjective enthusiasm of investigators （response rate 27%）, job stability of supervisors and research coordinators （27%）, compliance of subjects （45%）, quality control of the whole process of the circulation of test drugs, medical devices and biological samples （52%）, and the informatization level of clinical trial institutions （30%）.   Conclusion  Hospitals, institutions and project teams could take measures to cultivate and stabilize the drug clinical trial talent team, improve the quality management system of drug clinical trials, improve work efficiency, and promote the high-quality development of drug clinical trials in medical institutions.
History and prospects of the military hospital preparation rooms
WANG Jianping, YANG Zhihui, DAI Bo, SONG Qing
2026, 44(2): 108-112.   doi: 10.12206/j.issn.2097-2024.202504050
Abstract(1937) HTML(441) PDF (884KB)(21)
Abstract:
Military hospital preparation rooms are an important part of military medical institutions and have played an important role in military pharmacy support in history. However, with the development of science and technology, the improvement of domestic pharmaceutical production and innovation capabilities, and the adjustment of the military establishment and system, the establishment structure, functional tasks, and business forms of military medical institutions have undergone significant changes. The historical evolution of military preparation rooms were reviewed, the current situation were analyzed and the development challenges faced were identified. It was also explored how military hospital preparation rooms, as an important link in military pharmaceutical support, can face new situations and adapt to new forms of warfare. By enhancing the military efficiency of preparation rooms, it could play a greater role in improving medical support capabilities and enhancing the combat effectiveness of troops.
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