Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Online FirstMore>
Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
Display Method:
The efficacy and safety of once-a-week tirzepatide in adults with obesity: A Meta-analysis
LUAN Zenghui, YAN Meixing, LV Fuyun, LIU Bensheng, LIU Chang
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202512033
Abstract(73) HTML(59) PDF (2190KB)(2)
Abstract:
  Objective  To systematically evaluate the efficacy of once-weekly tirzepatide in participants with obesity.   Methods  We searched PubMed, Cochrane Library, Embase, and The ClinicalTrails.gov identify randomized controlled trials comparing the efficacy and safety of Tirzepatide with placebo in adults with obesity, and searched the databases up to July, 2025. The quality of literature was evaluated after they were screened according to inclusion and exclusion criteria. The Meta-analysis analyses were conducted by using RevMan 5.3 and R 4.4.2 software, and analyzed the efficacy with different dose.   Results  This study included 11 articles, with 7570 obesity participants. The Meta-analysis results showed that with the dose growing up, tirzepatide is more effective in weight loss, waist circumference loss, body mass index loss, achievement of ≥5%, ≥10% and ≥15% weight loss comparing with placebo. Gastrointestinal side effects were common but generally mild.   Conclusion  Once-a-week tirzepatide appears to be effective and generally well-tolerated in adults with overweight or obesity.
Exploring the mechanism of tanshinone ⅡA in ameliorating acetaminophen-induced liver injury based on network pharmacology and molecular docking techniques
ZHANG Tingyan, LI Tingting, LUO Yunchun, YUAN Xiaofeng, ZHANG Chuan, HAO Kai, BIAN Jun
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202412022
Abstract(273) HTML(190) PDF (7809KB)(5)
Abstract:
  Objective  To investigate the potential protective mechanism of tanshinone ⅡA against acetaminophen （APAP）-induced acute liver injury.   Methods  An acute liver injury model was constructed in APAP mice, and the protective effect of tanshinone ⅡA was evaluated based on the liver weight ratio, the levels of aspartate aminotransferase （AST） and alanine aminotransferase （ALT）, and hematoxylin-eosin （H&E） staining. Targets of tanshinone ⅡA were predicted by TCMSP, and a shared target PPI network was constructed by STRING 11.5 in combination with disease targets from GeneCards. The GO/KEGG enrichment analysis was performed by DAVID, and the component-target-pathway network was constructed; the molecular docking between tanshinone ⅡA and the core targets was performed by AutoDock and visualised.   Results  Compared with the normal group, the liver weight ratio and serum aminotransferase level of mice with acute liver injury were significantly elevated （P < 0.05）, and the pathological injury of liver tissue was obvious. After tanshinone ⅡA treatment, the above index were significantly reduced （P < 0.05）, and the pathological injury was significantly improved. Further network pharmacological analysis was carried out and found that KEGG pathway enrichment analysis focused on IL-17 signaling pathway and TNF signaling pathway, etc. In addition, the PPI core network showed that the key targets of tanshinone ⅡA to ameliorate acute liver injury mainly included TP53, AKT1, SRC, TNF and JUN. The molecular docking results showed that tanshinone ⅡA had high binding scores with the targets of MMP9, NFKB1, TNF, EP300 and SMAD3; and was able to bind to the targets of TP53, AKT1, SRC and JUN.   Conclusion  Tanshinone ⅡA may play a protective role against acute liver injury by regulating genes such as AKT1, JUN and TNF, and participating in signaling pathways such as TNF and IL-17.
Amelioration chloride-induced abdominal aortic aneurysm injury by activation of α7nAChR s calcium in mice
ZHANG Wenjing, FU Hui, GUO Xiaobin, GUO Hao
In Press  doi: 10.12206/j.issn.2097-2024.202409045
Abstract(7440) HTML(3039) PDF (3171KB)(31)
Abstract:
  Objective  To investigate the effect of activating α7 nicotinic acetylcholine receptor （α7nAChR） on calcium chloride （CaCl2）-induced abdominal aortic aneurysm （AAA） injury in mice.   Methods  AAA model was induced by CaCl2 in wild type （WT） mice and α7nAChR knockout （α7nAChR−/-） mice. The effects of knockout of α7nAChR on histological damage in CaCl2-induced AAA mice and expression of inflammatory factors were assessed by HE staining, EVG staining and IHC staining. Rat-derived primary vascular smooth muscle cells （VSMC） were stimulated with TNF-α, which mimicked the inflammatory environment of AAA. The expressions of inflammation-related proteins were detected by using Western-Blot with or without PNU-282987 to activate α7nAChR.   Results  Aortic dilatation was obvious, and the aortic structure was disrupted in CaCl2-induced AAA mice. Knockout of α7nAChR further exacerbated the histological injury and significantly up-regulated the expression of inflammation-related proteins in aorta of AAA mice. It was showed that TNF-α stimulation of VSMC increased inflammation-related protein expression, whereas activation of α7nAChR prevented the phenomenon.   Conclusion  Activation of α7nAChR could attenuate CaCl2-induced AAA injury in mice by suppressing the inflammatory response.
Research progress on the application potential and mechanism of elemental sulfur in the treatment of skin diseases
KOU Erwen, ZHANG Xiaobei, WANG Bo, ZHU Yuanjie
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202509041
Abstract(401) HTML(290) PDF (910KB)(7)
Abstract:
As a traditional Chinese medicine, elemental sulfur has long been used for the treatment of scabies and tinea. In recent years, with the in-depth study of the biological function of elemental sulfur, its function has been extended to the treatment of acne, eczema, rosacea and other skin diseases, and the various mechanisms of elemental sulfur involved in the prevention and treatment of skin diseases are gradually being elucidated: the dual regulatory effect of elemental sulfur on skin keratinization, anti-inflammatory effect, antibacterial effect, and insecticide-killing effect. However, the therapeutic effects and specific mechanisms of action of this drug vary in different diseases, and the related research still need to be improved. In addition, the effects of elemental sulfur on pharmacokinetics and skin healing need to be further explored. The application status and mechanism of elemental sulfur in common skin diseases were systematically reviewed in this paper, which and provided a new perspective for the future development of elemental sulfur in the prevention and treatment of skin diseases.
The content research on malonyl-ginsenoside Rb3 in different tissues of Panax ginseng, P. quinquefolium and P. notoginseng
CUI Xiaoxue, WANG Yingxia, ZHOU Guangxin, HUANG Xiaoyu, WANG Liuming, LIU Xiao
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202410049
Abstract(252) HTML(154) PDF (1071KB)(8)
Abstract:
  Objective  To compare the contents of malonyl-ginsenosides Rb3 （MG-Rb3） in different parts, including roots, stems, leaves and flowers, of Panax ginseng, P. quinquefolium and P. notoginseng. To explore the effects of two drying methods, constant temperature drying and vacuum freeze drying on their contents.   Methods  The contents of MG-Rb3 in P. ginseng, P. quinquefolium and P. notoginseng were compared based on HPLC analysis, using enzymatically synthesized MG-Rb3 as the reference standard.   Results  The buds of P. ginseng and P. quinquefolium exhibited relatively high levels of MG-Rb3, which were approximately 7.3-18.1 times and 2.8-4.3 times higher than those found in the roots, respectively, and the lowest contents were detected in the stems. The content of MG-Rb3 in P. notoginseng flower buds was about 31.2 times higher than that in leaves. The content of MG-Rb3 in the buds treated by constant temperature drying was about 1-1.1 times that of using vacuum freeze drying.   Conclusion  The highest content of MG-Rb3 was detected in the flower buds of P. ginseng and P. notoginseng, and the content of MG-Rb3 in leaves of P. quinquefolium was the highest. Content of MG-Rb3 in the buds after constant temperature drying was slightly higher than that of using vacuum freeze drying.
Progress in drug research for Alzheimer’s disease and application of cellular metabolomics
CAO Xiuyu¹, JIN Mengying, SHEN Shuqi, WANG Hui, HONG Zhanying
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202509026
Abstract(393) HTML(215) PDF (1114KB)(1)
Abstract:
Alzheimer’s disease （AD） is a typical neurodegenerative disorder, and its pathogenic mechanism remains to be fully elucidated. Currently, there are limited drugs available for the clinical treatment of AD, and many of these drugs are associated with numerous adverse effects. Traditional Chinese medicine （TCM）, featuring multi-component and multi-target properties, possesses unique advantages and potential in the prevention and treatment of AD. AD cell models enable in-depth investigations into the pathogenesis of AD and the mechanisms underlying drug-based prevention and treatment. Cell metabolomics studies changes in intracellular metabolites to accurately capture dynamic variations in metabolite types, contents, and metabolic pathways of cells under different physiological states; this approach holds promise for revealing the complex regulatory mechanisms of cellular metabolic networks, identifying AD-specific biomarkers, and providing support for research on the mechanisms of AD. This article reviews the drugs used for AD prevention and treatment, as well as recent progress in the application of cellular metabolomics in AD research, aiming to provide a reference for studies on AD mechanisms, clinical diagnosis and treatment, and drug development.
Study on quality standards of Liuwei Runfu oil recipe
HU Yue, WANG Yi, MA Minghua, LI Fulun, NIAN Hua, ZHU Jianyong
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202406033
Abstract(384) HTML(189) PDF (1491KB)(4)
Abstract:
  Objective  To establish a standardized quality criterion for the formula of the Liuwei Runfu oil recipe.   Methods  The qualitative identification of the components, such as Cannabis sativa, Ligusticum chuanxiong, Angelica sinensis, Coix lacryma-jobi, and Glycyrrhiza uralensis, was conducted by thin layer chromatography （TLC）. The concentration of Senkyunolide A, ligustilide, and linoleic acid was determined by high-performance liquid chromatography （HPLC）.   Results  The TLC identification results demonstrated excellent differentiation and high selectivity, without any disruption from the negative samples. The reference standard for Senkyunolide A exhibited excellent linearity in the range of 25 to 300 µg （r=0.9999）, with an average recovery rate of 102.3% and a relative standard deviation （RSD） of 2.3%. The ligustilide reference standard exhibited strong linearity between the concentrations of 0.6875 and 8.25 µg （r=0.9993）, with an average recovery rate of 100.1% and a relative standard deviation （RSD） of 2.8%. The linoleic acid reference standard demonstrated strong linear correlation within the range of 2.8125 to 33.75 µg （r=0.9990）, with an average spiking recovery rate of 102.7% and a relative standard deviation （RSD） of 1.7%.   Conclusion  The established method with strong specificity was simple, accurate, reliable, which coulod provide a reference for the quality control of the Liuwei Runfu oil recipe.
The efficacy of aerobic exercise combined with sertraline in the treatment of elderly patients with post-stroke depression, and its effect on cognitive function and inflammatory cytokine
ZHU Laiyun, WANG Nuan, SUN Lingchen, ZHAO Chao
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202508024
Abstract(3154) HTML(1362) PDF (1074KB)(26)
Abstract:
  Objective  To investigate the efficacy of aerobic exercise combined with sertraline in the treatment of post-stroke depression （PSD） in elderly patients and its effects on cognitive function and inflammatory cytokines.   Methods  70 elderly PSD patients admitted to the Xuzhou Municipal Hospital affiliated with Xuzhou Medical University from June 2022 to December 2024 were selected as study objects. Patients were randomly divided into control group treated with sertraline and study group treated with aerobic exercise combined with sertraline. The treatment duration was 8 weeks. The Hamilton Depression Rating Scale （HAMD） scores, the clinical efficacy, cognitive function [Mini Mental State Examination （MMSE）], and the levels of inflammatory cytokines （IL-1β, IL-6, TNF-α） were compared before and after treatment.   Results  No significant differences in baseline data were observed between the two groups before treatment. After 4 and 8 weeks of treatment, HAMD scores were significantly decreased compared to baseline in both groups （all P<0.05）. The study group showed significantly lower HAMD scores than the control group at both 4 and 8 weeks （all P<0.05）. The overall clinical effective rate was significantly higher in the study group （94.29%） than in the control group （77.14%）（P<0.05）. MMSE scores were significantly increased compared to baseline in both groups at 4 and 8 weeks（all P<0.05）, and the study group demonstrated significantly higher MMSE scores than the control group at both time points （all P<0.05）. Similarly, serum levels of IL-1β, IL-6, and TNF-α were significantly reduced from baseline in both groups at 4 and 8 weeks （all P<0.05）. The reductions in these inflammatory cytokine levels were significantly greater in the study group compared to the control group （all P<0.05）. The incidence of adverse reactions was 8.57% in the control group and 5.71% in the study group, with no statistically significant difference （P>0.05）.   Conclusion  The combination of aerobic exercise and sertraline is a safe and reliable therapeutic strategy for elderly PSD patients, alleviating depressive symptoms, improving cognitive function, and reducing systemic inflammation.
Efficacy and safety comparison of EGFR-TKIs monotherapy and combination therapy as first-line treatment for advanced non-small cell lung cancer: a network meta-analysis
CHEN Guanxu, SONG Yutong, GUO Xiuqiang, ZHANG Mi, LIU Zhihong, SONG Hongtao
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202504044
Abstract(11699) HTML(6973) PDF (3982KB)(41)
Abstract:
  Objective  To investigate the efficacy and safety of EGFR-TKIs monotherapy and its combination therapy in the first-line treatment of advanced non-small cell lung cancer（NSCLC）patients with EGFR mutations.   Methods  Databases such as PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were systematically searched to collect eligible phase II/III randomized controlled trials （RCTs）, with the time range from the establishment of the databases to June 2023. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the studies. Outcome data, including overall survival （OS）, progression-free survival （PFS）, objective response rate （ORR）, grade 3 or higher adverse events （≥3 AEs）, and serious adverse events （SAEs）, were collected. A network meta-analysis was performed using R software （version 4.2.1） under the Bayesian theoretical framework. Subgroup analyses of survival outcomes （OS, PFS） were conducted based on different clinical and pathophysiological characteristics of the patients.   Results  A total of t wenty-eight phase II/III RCTs were included in the study, involving a total of 7 460 patients and 18 first-line treatment regimens. The results showed that in terms of efficacy, gefitinib + pemetrexed-containing chemotherapy performed best in OS and ORR, while osimertinib + bevacizumab performed best in PFS. In terms of safety, furmonertinib had the lowest incidence of ≥3 grade AEs, and osimertinib had the lowest incidence of SAEs. Subgroup analysis results indicated that the efficacy and safety of various treatment regimens differed among patients with different clinical and pathological characteristics.   Conclusion  Monotherapy with third-generation EGFR-TKIs, represented by osimertinib, serves as the preferred therapeutic option considering both efficacy and safety profiles. While some combination therapies can enhance survival benefits, but need to be vigilant about increased toxicity. Clinical decision-making should be tailored based on patient' mutation subtypes, comorbidities, and tolerance.
Analysis of the hotspots and advantages of adverse drug reaction automatic monitoring system based on CiteSpace and systematic review
WANG Yan, KANG Le, CHEN Wen, FANG Qi, YU Zhongwang, CAO Li
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202501034
Abstract(7561) HTML(1454) PDF (1309KB)(27)
Abstract:
  Objective  To provide a reference for the establishment, development and application of the adverse drug reaction （ADR） automated monitoring system, through verifying and quantifying the research hotspots and advantages of the system by CiteSpace software and systematic review.   Methods  Literature on ADR automated monitoring up to December 2023 were retrieved and screened from CNKI and web of science databases. CiteSpace 6.4.R1 software was used to conduct co-occurrence, clustering and emergence analysis, and to visualize and comparatively analyze the research hotspots, rules and distribution in the field of automated monitoring of ADR at home and abroad. In compliance with the preferred reporting items for systematic reviews and Meta-analyses （PRISMA）, literature covering publications in English and Chinese including detection rates of ADRs collected using Incident Reporting Systems （IRSs） and/or automated monitoring systems were retrieved and screened. The advantages and disadvantages of automated monitoring systems were analyzed by comparing the differences between these two systems in terms of the number of ADR reports and the types of positive signals.   Results  A total of 56 articles in English and 80 articles in Chinese were indexed by CiteSpace. The research hotspots in recent years included data mining, deep learning, text classification techniques, machine learning and so on. A total of seven studies compiled with the inclusion criteria for the systematic evaluation, all of which were completed between 1991 and 2021 in hospitals in four countries. 150 526 medical records were reviewed from 15 institutions. A total of 194 ADR reports were collected by IRSs. A total of 2 090 ADR reports were collected by the automated monitoring system over the same period, indicating a 977% increase in the number of ADR reports （P=0.0156） compared with the IRSs.   Conclusion  The ADR automatic monitoring system had significantly improved the level of drug risk identification and reduced costs, but it was necessary to optimize the algorithm, expand the data source and carry out standardization construction to overcome the current limitations.
Effect of remimazolam premedication on emergence delirium in children undergoing tonsillectomy and （or）adenoidectomy
WANG Fei, ZHANG Rui, XU Yong, CHEN Xian, ZHU Yumin
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202411036
Abstract(4834) HTML(1457) PDF (853KB)(16)
Abstract:
  Objective   To evaluate the effect of remimazolam premedication on emergence delirium （ED） in children undergoing tonsillectomy and （or） adenoidectomy.   Methods  Children aged 3-6 years who underwent tonsillectomy and （or） adenoidectomy with general anesthesia in Zhongshan Hospital Affiliated to Xiamen University from July 2023 to September 2024 were randomly divided into group 0.1 mg/kg remimazolam （group R1）, group 0.2 mg/kg remimazolam （group R2） and normal saline group （group P）. Three groups were sedated preoperatively with remimazolam 0.1 mg/kg, remimazolam 0.2 mg/kg and normal saline, respectively. The primary outcome was the incidence of ED. The secondary outcomes included the parental separation anxiety scale （PSAS） score when entering the operating room, the induction compliance checklist （ICC） score at induction, the anesthetic recovery time, the incidence of rescue propofol for ED, the face, legs, activity, cry, and consolability （FLACC） score and the incidence of postoperative pain during the recovery period, the incidence of adverse reactions during the operation and postoperatively, and the incidence of negative postoperative behavioral changes （NPOBCs） at 1 day, 7 days, and 30 days postoperatively.   Results  A total of 119 children completed the study, including 41 in group R1, 38 in group R2, and 40 in group P. The incidence of ED and propofol rescue, the PSAS scores and ICC scores of group R1 and R2 were lower than that of group P （P<0.05）, and the above results in group R2 was better than those in group R1 （P<0.05）. The FLACC score, the incidence of postoperative pain, and the incidence of adverse reactions between the three groups had no difference （P>0.05）. The incidence of NPOBCs at 1 day and 7 days postoperatively of the group R1 and group R2 was lower than of the group P （P<0.05）, but no difference in that was detected at 30 days postoperatively among the three groups （P>0.05）.   Conclusion  Remimazolam used for preoperative sedation could reduce the incidence of ED in children undergoing tonsillectomy and （or） adenoidectomy, and had a positive effect on alleviating the preoperative anxiety and preventing NPOBCs
The Evolutionary Pattern of Meaning in Life Among University Students and Its Association with Depressive Symptoms
YU Yongju, HE Min
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.20240380
Abstract(7123) HTML(2296) PDF (985KB)(26)
Abstract:
This study aimed to clarify the causal relationship between meaning in life and depression symptoms, explore the evolutionary patterns of meaning in life, and assess its impact on the incidence of depressive symptoms. A two-wave longitudinal study with a 12-month interval was conducted among 896 university students recruited from one university. The meaning in life questionnaire and the depression symptom screening questionnaire were administered. The findings showed that: 1）Meaning in life at T1 negatively predicted depression symptoms at T2. Conversely, depression symptoms at T1 did not significantly predict meaning in life at T2. 2）The evolutionary patterns of meaning in life from T1 to T2 could be categorized into four groups: sustained low meaning, meaning improvement, meaning reduction, and sustained high meaning. The incidence of depressive symptoms in these four groups was 13.00%, 5.00%, 12.00%, and 4.00%, respectively. 3）The evolutionary patterns of meaning in life significantly impacted the incidence of depressive symptoms. Compared to the sustained high meaning group, both the sustained low meaning group and the meaning reduction group exhibited significantly higher rates of depression symptoms. The results suggest that psychological health education in universities should focus on individuals with sustained low meaning or meaning reduction, and that enhancing meaning in life serves as an effective intervention approach to reducing the incidence of depression symptoms among university students.
Design, synthesis, and in vitro anti-inflammatory activity of novel Matrine derivatives
LU Yifei, SONG Jia, SHEN Hongxia, ZHAO Qingjie
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202503005
Abstract(9593) HTML(4452) PDF (1044KB)(56)
Abstract:
  Objective  The alkaloids contained in the Chinese herb Sophora flavescens have good anti-inflammatory activity. To investigate the structure-activity relationship between the novel Matrine and the anti-inflammatory activity by modifying the structure of Matrine .   Methods  Fourteen novel Matrine derivatives were obtained by chemical modification using Matrine as the lead compound with Matrine and M19 as positive controls. The cytotoxicity of Matrine derivatives against RAW264.7 cells was detected by the Cell Counting Kit 8 （CCK8） assay, and the relative amount of Nitric Oxide （NO） produced by Matrine derivatives against Lipopolysaccharide （LPS）-induced inflammation model of RAW264.7 cells was detected using an NO assay kit. The Enzyme-Linked Immunosorbent Assay （ELISA） d was used to detect the secretion of Interleukin-6 （IL-6） and Tumor Necrosis Factor Alpha （TNF-α） by Matrine derivatives in LPS-induced inflammation model of RAW264.7 cells.   Results  The novel Matrine derivatives all exhibited lower cytotoxicity compared with M19. The NO inhibition rates of the novel Matrine derivatives were all higher than that of Matrine, and some were higher than that of M19 , with compound A12 having the highest NO inhibition rate. Compounds A11 and A12 showed higher IL-6 inhibition than the control M19 . Additionally, compound A12 had higher TNF-α inhibition than the control M19 .   Conclusion  Compound A12 inhibited the strongest inhibition of NO, IL-6 and TNF-α release and had the best anti-inflammatory activity, which provided an important lead compound for this subsequent in-depth study.
The preventive and therapeutic effects of three ethanol extracts derived from three sources of Stellera chamaejasme L., on imiquimod-induced psoriasis in mice
PENG Ying, LIU Xin, NIE Yiwen, WANG Xinhe, NIAN Hua, ZHU Jianyong
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.202406029
Abstract(14924) HTML(4005) PDF (2882KB)(45)
Abstract:
  Objective  To investigate the preventive and therapeutic effects of ethanol extracts derived from three sources of traditional Chinese medicine: Stellera chamaejasme L., Euphorbia fischeriana Steud., and Euphorbia kansuensis Prokh., on imiquimod （IMQ）-induced psoriasis in mice.   Methods  Thirty-six male BALB/c mice were randomly divided into the following 6 groups with 6 mice in each group: blank control, model, Stellera chamaejasme, Euphorbia fischeriana, Euphorbia kansuensis, and calcipotriol. PASI （Psoriasis Area and Severity Index） scores were used to record the changes of skin lesions in each group; HE （hematoxylin-eosin） staining was used to observe the pathological morphology of skin and measure the thickness of the epidermis. Immunohistochemistry was used to detect the expression of nuclear antigen Ki67 in the skin tissues of mice.   Results  Compared with the model group, the three kinds of ethanol extracts can reduce the PASI score, inhibit epidermal thickening, and decrease expression of Ki67 in the psoriasis mice. Among them, the therapeutic effect of Stellera chamaejasme was the most significant and it was better than the commonly used topical drug calcipotriol.   Conclusion  The ethanol extract of Stellera chamaejasme has good anti-psoriatic activity, can inhibit the abnormal proliferation of keratinocytes, can reduce the expression of Ki67, and can significantly improve psoriasis-like skin lesions.
Accepted Manuscript  doi: 10.12206/j.issn.2097-2024.
Abstract(6759) HTML(2735) PDF (0KB)(609)
Abstract:
currentMore>
Cover Catalogue
Column
Display Method:
Reviews
Research progress on the effects and mechanisms of plateau hypoxia on drug metabolism
LI Qian, WANG Rong, YANG Feng, WANG Xiaofeng, YIN Dongfeng
2026, 44(6): 275-279.   doi: 10.12206/j.issn.2097-2024.202403018
Abstract(6709) HTML(927) PDF (892KB)(14)
Abstract:
The plateau region is known for its unique environmental characteristics of low oxygen, low pressure, strong radiation, cold and dryness. Under the low oxygen environment, human physiological functions and drug metabolism are significantly affected. In order to gain a deeper understanding of drug metabolism in the plateau hypoxic environment and to guide the rational use of drugs in the plateau region, the effects of plateau hypoxia on drug metabolism were reviewed in this paper, which focused on changes in metabolic profiles, enzyme activity and expression, and probed the relevant mechanisms in depth.
Original articles
Evaluation of anticancer activity of marine microbial secondary metabolites based on intrahepatic cholangiocarcinoma organoid models and study on its induction of cancer cell apoptosis
FAN Xiaoting, MAO Zhifan, LIU Jian, YANG Fan, LIN Houwen
2026, 44(6): 280-288, 312.   doi: 10.12206/j.issn.2097-2024.202603003
Abstract(249) HTML(99) PDF (4721KB)(1)
Abstract:
  Objective  To investigate the anti-intrahepatic cholangiocarcinoma （ICC） activity and mechanism of 2-heptyl-3-hydroxy-4（1H）-quinolone （PQS）, a secondary metabolite of polar marine microorganisms.   Methods  Patient-derived organoid （PDO） models were established using intrahepatic cholangiocarcinoma （ICC） tumor tissues obtained from Renji Hospital, Shanghai Jiao Tong University School of Medicine. Hematoxylin and eosin （HE） staining was performed to assess the histomorphological characteristics of both patient ICC tissues and corresponding PDOs. Immunohistochemistry （IHC） was employed to evaluate CYP3a expression in patient ICC tissues and PDOs. The antiproliferative activity of PQS against stably passaged PDOs was determined using an adenosine triphosphate （ATP）-based bioluminescence assay, and dose-response curves were fitted to calculate the half-maximal inhibitory concentration （IC50） for assessing the anti-ICC efficacy of PQS. In the human intrahepatic cholangiocarcinoma RBE cell model, the effects of PQS on RBE cell proliferation were evaluated by the cell counting kit-8 （CCK-8） assay; colony formation capacity was assessed by the plate colony formation assay; cell cycle distribution and apoptosis were analyzed by flow cytometry; and the protein expression levels of cyclin-dependent kinase 2（CDK2）, CDK4, RelA（p65）, and nuclear factor-κB1（p50） were detected by Western blotting.   Results  Two ICC PDO models were successfully established. Histomorphological observation revealed that the PDO tissues after serial passaging exhibited morphological features essentially consistent with the corresponding patient ICC tissues, both presenting as cystic vesicle-like structures. Immunohistochemical analysis demonstrated that CYP3a was expressed in both PDO tissues and patient ICC tissues. ATP-based bioluminescence assay results indicated that PQS effectively suppressed ATP content in PDO tissues, with a fitted dose-response curve yielding an IC50 value of 2.49 µmol/L. In the RBE cell model, PQS inhibited RBE cell viability in a concentration-dependent manner, and the fitted dose-response curve yielded an IC50 value of 1.05 µmol/L. Furthermore, PQS at concentrations of 1, 2, and 4 µmol/L significantly suppressed colony formation of RBE cells, arrested the cell cycle at the S phase, induced apoptosis, and downregulated the expression of proteins associated with the NF-κB signaling pathway.   Conclusion  ICC PDO models were successfully established, confirming the anti-ICC activity of PQS. PQS inhibited RBE cell proliferation, potentially via the NF-κB signaling pathway, by arresting the cell cycle at the S phase and inducing apoptosis of RBE cells
The hypolipidemic function and hepatic protective effects of Xuetong capsules
HE Lin, CHENG Yanqiong, ZHAO Juanjuan, LU Huilan, YANG Jun, CHEN Fangjian
2026, 44(6): 289-295, 321.   doi: 10.12206/j.issn.2097-2024.202502015
Abstract(8986) HTML(3412) PDF (3017KB)(57)
Abstract:
  Objective  To investigate the effects of Xuetong capsule on blood lipids and liver lesion in hyperlipidemic model animals.   Methods  Sixty ICR mice were randomly divided into six groups. The normal control group was fed with normal diet, the other groups were fed with high-fat diet to induce hyperlipidemia. After four weeks feeding, the three groups were given low, middle, and high doses of Xuetong capsules （0.5, 1.0, and 2.0 g/kg） by gavage, and the positive drug control group was given atorvastatin calcium （1.5 mg/kg） by gavage. The model group was given solvent （0.5% carboxymethyl cellulose sodium）. After treatment for 8 weeks, the body weight, organ index, blood lipids, blood glucose and liver function index were measured. The liver oil red staining was used to determine the lipid droplet content, and quantitative PCR was used to detect the expression of inflammatory factors TNF-α, IL-6, and IL-1β.   Results  The body weight, the weight of liver and spleen were significantly increased by high-fat diet. High-fat diet increased the organ indexes of the liver and spleen, the degree of liver oil red staining, and also significantly increased the levels of glucose, triglyceride （TG）, cholesterol （CHOL）, and low-density lipoprotein cholesterol （LDL-C） in serum. Compared with the model group, the level of TG has no significant change in low, middle and high doses groups. The level of CHOL in serum was reduced by Xuetong capsule with a dose dependent manner. There were significant difference between the model group and middle, high doses groups. The results of LDL-C were similar, the level of LDL-C was significantly reduced by middle and high doses groups [middle dose (0.55±0.21) mmol/L, high dose (0.52±0.22) mmol/L vs (0.81±0.29) mmol/L in model group, P<0.05]. Compared with the normal control, there was no significant difference in HDL-C levels between the high-fat model and each drug-treated group. Liver function showed that Xuetong capsules significantly reduced the degree of liver oil red staining and decreased the level of alanine aminotransferase （ALT） induced by high-fat diet. The body weight, the weight and organ indexes of liver and spleen were significantly reduced by positive drug control group. The levels of CHOL, LDL-C, and TG, and the degree of liver oil red staining were also significantly reduced in positive drug control group. Further studies have shown that high dose of Xuetong capsules significantly reduced the expression of TNF-α and IL-6 induced by high-fat diet （P<0.05）, while the reduction of IL-1β was not so significant （P>0.05）.   Conclusion  Xuetong capsules significantly reduced the body weight of animals with high fat, liver size, fat deposition, inflammatory damage and also significantly reduced blood lipid CHOL and LDL-C levels and transaminase elevation. The above effects may be related to Xuetong capsules reducing the expression of inflammatory factors such as TNF-α and IL-6 in the liver.
Mechanism of Jianfu mixture in the treatment of erectile dysfunction based on network pharmacology analysis, molecular docking and in vitro experimental validation
YANG Yantao, YU Chao, ZHANG Zhihang, PAN Yujiong, HE Xiaofeng, XU Min
2026, 44(6): 296-305.   doi: 10.12206/j.issn.2097-2024.202407013
Abstract(9894) HTML(1748) PDF (2174KB)(16)
Abstract:
  Objective  To explore the molecular mechanism of Jianfu mixture in the treatment of erectile dysfunction （ED） by network pharmacology and molecular docking techniques, and validate its core targets and mechanisms through in vitro experiments.   Methods  The active components and corresponding molecular targets of Jianfu mixture were searched by searching TCMSP and Batman-TCM databases, and the disease targets of ED were searched by using GeneCards database. Find the intersection of drug ingredient target and disease target. The interaction between intersected targets was described and analyzed by String database, and the analysis results were visualized by Cytoscape software to determine the core target and the corresponding active components. GO functional enrichment analysis and KEGG pathway enrichment analysis were performed for intersection targets; the core target within the intersection were found through MCODE plug-in on Cytoscape software and molecular docking was performed with the corresponding active ingredients. An endothelial dysfunction model was established by transfecting HUVECs with si-eNOS. Intervene with different concentrations of the Jianfu mixture for the model cells for 24 h. QPCR was used to detect mRNA expression of core targets （MAPK1, MAPK3, JUN, ESR1, MAPK8）; Western blot was used to analyze protein expression （eNOS, JUN, p-JUN, MAPK, p-MAPK） and phosphorylation levels.   Results  144 effective active components and 168 active components target-disease targe intersection of Jianfu mixture were obtained. GO analysis revealed 200 5 biological processes, 151 molecular functions, and 63 cellular components. KEGG analysis yielded 181 pathways. 5 core targets including MAPK1, MAPK3, JUN, ESR1 and MAPK8 were screened out. The active components such as β-sitosterol, kaempferol, astapterocarpan had good binding affinity with the core target. In vitro experiments confirmed successful construction of the endothelial dysfunction model （eNOS expression significantly decreased after si-eNOS transfection）. Jianfu mixture dose-dependently inhibited mRNA expression of MAPK1, MAPK3, JUN, ESR1, and MAPK8. Additionally, it reduced phosphorylation levels of JUN and MAPK, indicating inhibition of the JNK/c-Jun and ERK/MAPK signaling pathways to improve endothelial function.   Conclusion  Jianfu mixture treats ED by suppressing abnormal activation of multi-target signaling pathways （MAPK/JUN/ESR1）, reducing endothelial apoptosis, and promoting NO synthesis. This mechanism aligns with the traditional Chinese medicine principle of “activating blood circulation, resolving stasis, tonifying Qi, and strengthening cardiovascular function.” The study provided molecular-level evidence for the therapeutic efficacy of Jianfu mixture in ED management.
Research reports
Visual analysis of domestic literature on traditional Chinese medicine herbal compresses by CiteSpace
WANG Mengxin, YU Lei, TAN Xiao
2026, 44(6): 306-312.   doi: 10.12206/j.issn.2097-2024.202506001
Abstract(392) HTML(208) PDF (6064KB)(3)
Abstract:
  Objective  To visually analyze the research literature of traditional Chinese medicine （TCM） herbal compresses in China by CiteSpace software, sort out the development process and direction changes of research, reveal cutting-edge hotspots, predict research trends, and provide reference for in-depth research and application of TCM herbal compresses.  Methods  Literature related to TCM herbal compresses were retrieved from databases including China National Knowledge Infrastructure （CNKI）, Wanfang Data Knowledge Service Platform, VIP Journal Integration Platform （VJIP）, covering the period from September 1, 2002 to November 15, 2024. CiteSpace software was used for visualization analysis.   Results  A total of 508 documents were included, and the annual publication volume showed a fluctuating growth. The number of publications was higher in northern regions than in southern regions, with Jilin and Henan provinces being the majority. The institution with the highest number of publications was Changchun University of TCM. The authors with the highest number of publications were Xing Linbo and Hou GuiHong. Collaboration among authors and institutions was generally suboptimal, with limited cross-regional cooperation. The top three high-frequency keywords were nursing, （clinical） efficacy, and pain. The emerging keywords indicated that adverse reactions, clinical efficacy, and traditional Chinese medicine rubbing were hot topics in the study of Chinese medicine herbal compresses.   Conclusion  The research on TCM herbal compresses in China was in a steady development stage, with research hotspots focused on clinical efficacy observation and adverse reactions of multiple therapies combined. In the future, cross institutional cooperation and in-depth research need to be strengthened to promote further development in this field.
Medicine & Clinical
Practice and analysis of the simplified oral premedication protocol with paclitaxel liposome in patients of advanced gastric cancer
ZHONG Ling, CAO Jinfa, HE Miao, TIAN Jing
2026, 44(6): 313-316.   doi: 10.12206/j.issn.2097-2024.202406047
Abstract(7463) HTML(2646) PDF (836KB)(21)
Abstract:
  Objective  To explore a feasible simplified premedication protocol for preventing hypersensitivity reactions to taxanes.   Methods  The electronic medical record system was used to search for data from 49 patients with advanced gastric cancer who received paclitaxel liposome treatment for the first time in the gastroenterology department of Shanghai Changhai Hospital from 2021-06-01 to 2024-06-30, including premedication protocols, allergic reactions, and other adverse reactions.   Results  Among 31 patients, the premedication regimen included oral dexamethasone 9 mg at 12 h and 6 h prior to liposomal paclitaxel, plus oral loratadine 10 mg and oral ranitidine 150 mg at 12 h prior to treatment. Among 18 patients, the regimen included oral dexamethasone 9 mg at 12 h and 6 h prior to treatment, and oral loratadine 10 mg at 12 h prior to treatment. None of the patients experienced allergic reactions. The incidence of other adverse reactions did not differ significantly between the two groups（P>0.05）.   Conclusion   Based on literature and practice, a dual simplified premedication protocol of oral corticosteroids（GC）combined with oral H1 receptor blockers（H1RA）was proposed, which provided a new idea for doctors. Further clinical studies are needed to verify its effectiveness.
Pharmacy administration
The establishment and application of an online intelligent medication follow-up platform for outpatient patients
WANG Yushuang, LIU Yulong, QIU Ji
2026, 44(6): 317-321.   doi: 10.12206/j.issn.2097-2024.202408025
Abstract(426) HTML(264) PDF (1251KB)(3)
Abstract:
  Objective  To promote rational drug use and improve the quality of outpatient pharmacy services by establishing an intelligent medication follow-up platform and carrying out online medication follow-up for outpatients.   Methods  The Internet and WeChat mini programs were used to establish an intelligent medication follow-up platform, and effective follow-up records were selected from June 1, 2023 to May 31, 2024 to analyze the results of patients' follow-up.   Results  The platform could automatically push follow-up messages to patients and supports the exchange of text, pictures, and voice communication between pharmacists and patients. A total of 613 patients were selected to participate in the follow-up. Thirteen blood glucose records and 17 blood pressure readings were uploaded, and 583 medication consultations were recorded.   Conclusion  This study tracked and understood the medication situation of outpatients through an intelligent medication follow-up platform. The platform was professional, intelligent, and convenient, which was conducive to improving the safety of patients' home medication and promoting reasonable medication.
Optimizing the whole-process quality control system of intravenous drug distribution center based on failure mode and effect analysis
WEI Wei, ZHANG Mingxia, ZHOU Yanping, YAN Lan, TIAN Peng, FENG Xia
2026, 44(6): 322-328.   doi: 10.12206/j.issn.2097-2024.202504131
Abstract(5500) HTML(2231) PDF (1035KB)(30)
Abstract:
  Objective  To explore the application effect of a standardized management method based on failure mode and effect analysis （FMEA） in optimizing the whole-process quality control system of the intravenous admixture service （PIVAS）.  Methods  The quality control management system of the PIVAS was optimized by establishing six quality control groups led by the head nurse, with full participation of pharmacy, nursing, and logistical staff, ensuring comprehensive coverage and traceability of all quality control links. Each group conducted risk priority number （RPN） scoring for potential failure modes in their respective quality control processes, and targeted improvement measures were formulated based on the scoring results. The RPN values of failure modes and quality control-related evaluation indicators before and after implementation were compared to achieve closed-loop management.   Results  After one year of management, the RPN values of the six major failure modes significantly decreased compared to those before implementation （P<0.05）. The compounding error rate dropped to 0.13%, the dispensing error rate decreased to 0.95%, the compounding efficiency increased to 98%, the delivery time was shortened by 0.45 h per batch, the intervention rate for irrational prescriptions rose to 94.87%, satisfaction improved to 96.78%, and the participation rate of quality control personnel reached 95.36% （P<0.05）.   Conclusion  FMEA-based identification of potential failure modes in the whole-process quality control system of the IVAS, combined with risk quantification and targeted interventions, significantly reduced high-risk failure modes, improved compounding accuracy and efficiency, and ensured the safety of clinical intravenous medication and the effectiveness of healthcare quality management.
过刊浏览

Chief Editor: LI Jie Wei

Publication Number:

ISSN 2097-2024   CN  31-2185/R

Website: www.yxsjzz.cn or yxsj.smmu.edu.cn

Email: yxsjzzs@163.com

Contribution System

Email alert
RSS

Search

Search Type

NewsMore >

Top View Top Down
Wechat

友情链接

版权所有：《药学实践与服务》编辑委员会

Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号 沪ICP备05003363号-1

Supported by: Beijing Renhe Information Technology Co., Ltd.