Current Articles
2025, Volume 45, Issue 3
Display Method:
2025,
43(3):
97-108, 116.
doi: 10.12206/j.issn.2097-2024.202405013
Abstract:
The Keap1-Nrf2 pathway has been shown to be an important defense mechanism against oxidative stress, which may be an effective therapeutic strategy for many diseases. The research progresses on Keap1-Nrf2 pathway in inflammatory diseases were mainly ...
The Keap1-Nrf2 pathway has been shown to be an important defense mechanism against oxidative stress, which may be an effective therapeutic strategy for many diseases. The research progresses on Keap1-Nrf2 pathway in inflammatory diseases were mainly ...
2025,
43(3):
109-116.
doi: 10.12206/j.issn.2097-2024.202410034
Abstract:
At the end of 2020, the FDA issued emergency use authorization for two mRNA vaccines（BNT162b2 and mRNA-1273 ）, which had provided important support in the response to the COVID-19 pandemic. The great success of these COVID-19 vaccines based on non-vir...
At the end of 2020, the FDA issued emergency use authorization for two mRNA vaccines（BNT162b2 and mRNA-
2025,
43(3):
117-123.
doi: 10.12206/j.issn.2097-2024.202409031
Abstract:
Objective To construct the platelet-specific Metrnl gene knockout （Plt-Metrnl-/-）mice model. Methods Based on the Cre-LoxP system, Metrnlloxp/loxp mice, previously constructed in our laboratory, were mated with Pf4-Cre mice to generate Plt-Met...
2025,
43(3):
124-135.
doi: 10.12206/j.issn.2097-2024.202501019
Abstract:
Objective To design and synthesize novel Hsp90 inhibitors with dual functions of synergistically enhancing the antifungal activity of fluconazole （FLC） against drug-resistant fungi and anti-tumor activity based on the Hsp90 inhibitor Ganetespib. ...
2025,
43(3):
136-142, 150.
doi: 10.12206/j.issn.2097-2024.202310043
Abstract:
Objective To prepare and characterize caspofungin acetate-loaded solid lipid nanoparticles using glycerol monostearate （CAS-SLNs）, and investigate the antifungal effect of potentiation on Candida albicans in vitro and in vivo. Methods A high ...
2025,
43(3):
143-150.
doi: 10.12206/j.issn.2097-2024.202312027
Abstract:
Objective To investigate the material basis and mechanism of Danshen Baizhu prescription in coronary heart disease, vascular dementia and idiopathic membranous nephropathy based on network pharmacology. Methods TCMSP, PubChem, UniProt, GeneCar...
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