新型非甾体抗炎药—氟比洛芬制剂学研究进展
Researching development of flurbiprofen on pharmaceutics
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摘要: 目的 介绍新型非甾体抗炎药-氟比洛芬制剂学的研究进展。方法 综述氟比洛芬的口腔控缓释制剂、透皮给药制剂、固体分散体、脂质体、环糊精包合物等新剂型、新工艺研究。结论 氟比洛芬是一种消炎镇痛作用强,毒副作用小的新一代非甾体抗炎药,普通片剂口服生物利用度低,可引起胃肠道反应等副作用,可以通过其控缓释制剂的剂型研究来弥补普通剂型的缺点,以发挥氟比洛芬这一新型药物的良好治疗效果。Abstract: OBJECTIVE The new dosageform(such as controlled and sustained release system,transdermal therapeutic product,solid dispersion,liposome,and cyclodextrin)of flurbiprofen were summarized. CONCLUSION Flurbiprofen is a new non-steroid anti-inflammation drugs which has strong anti-inflammation and antalgic function,but it has low bioavailability,and may bring gastric side effect.Preparing controlled and sustained release product can overcome it disadvantage,and play its good therapeutic function.
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