门诊和急诊抗菌药物处方超说明书情况调查分析

谭朝丹; 时扣荣; 刘娟; 顾伟鹰; 陈伟成

doi:10.3969/j.issn.1006-0111.2015.04.023

门诊和急诊抗菌药物处方超说明书情况调查分析

doi: 10.3969/j.issn.1006-0111.2015.04.023

上海市第七人民医院药学部, 上海 200137

基金项目: 浦东新区中药药剂学科(示范中药房)建设项目(PDZYXK-2-2013002);上海市第七人民医院"七院新星"人才培养项目(XX2014-04)

Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients

Department of Pharmacy, Seventh People's Hospital of Shanghai, Shanghai 200137, China

摘要: 目的对门诊、急诊抗菌药物超说明书用药情况进行调研分析,为探索适合医院实际的超说明书用药管理模式提供依据。方法随机抽取上海市第七人民医院2013年门诊、急诊10%的抗菌药物处方进行点评,对超说明书用药情况进行评估,统计各类抗菌药物超说明书使用率、超说明书用药类型分布,并评价其合理性。结果共抽取门、急诊抗菌药物处方23 600张,涉及9大类,共43种抗菌药物,总体超说明书使用率为22.00%;超说明书处方数量最多的是头孢菌素类(13 206张),超说明书使用率最高的为硝基咪唑类(73.45%);超说明书用药类型主要表现为超频次(55.64%)、超剂量(52.60%),口服药品超剂量最为显著(72.46%),与之相比,注射剂主要表现为超给药频次(82.18%)、超溶媒(38.80%)。结论医院抗菌药物超说明书用药现象较为严重,大部分属于不合理用药,少有合理依据,总体亟待规范。
- 抗菌药物 /
- 超说明书用药 /
- 调查分析
Abstract: Objective To investigate the off-label use of antibacterials in out-patient department and emergency departmentand give reference for management. Methods About 10% of antibacterials prescriptions in out-patient department and emergency department were randomly extracted. Off-label use was analyzed by assessing off-label use percentage, reviewing off-label types and evaluating the rationality. Results 23 600 antibacterial prescriptions, including 43 antibacterials in 9 categorieswere analyzed, and the off-label use percentage of 22.00%. Cephalosporins contributed most in the amount of off-label use prescriptions, while nitroimidazoleseries got the highest off-label percentage of 73.45%. Improper frequency and dosing were the most obvious phenomena, with the ratio of 55.64% and 52.60%, respectively. For oral drugs, most frequent off-label use type of these drugs was improper dosing (72.46%).For injections, frequent off-label use type of these drugs were manifested improper frequency (82.18%) and improper solvent (38.80%). Conclusion Off-label use of antibacterials in hospital was in a critical situation and most of the prescriptions were lack of rational evidence.Standardized administration should be introduced.
- antibacterials /
- off-label use /
- investigation and analysis

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门诊和急诊抗菌药物处方超说明书情况调查分析

doi: 10.3969/j.issn.1006-0111.2015.04.023

Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients

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门诊和急诊抗菌药物处方超说明书情况调查分析

doi: 10.3969/j.issn.1006-0111.2015.04.023

上海市第七人民医院药学部, 上海 200137

English Abstract

Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients

Department of Pharmacy, Seventh People's Hospital of Shanghai, Shanghai 200137, China

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留言板

门诊和急诊抗菌药物处方超说明书情况调查分析

doi: 10.3969/j.issn.1006-0111.2015.04.023

Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients

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门诊和急诊抗菌药物处方超说明书情况调查分析

doi: 10.3969/j.issn.1006-0111.2015.04.023

上海市第七人民医院药学部, 上海 200137

English Abstract

Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients

Department of Pharmacy, Seventh People's Hospital of Shanghai, Shanghai 200137, China

全文HTML

目录