抗病毒药物研究进展及其在军事方面的应用

陆顺超; 阎澜

doi:10.3969/j.issn.1006-0111.2019.03.002

抗病毒药物研究进展及其在军事方面的应用

doi: 10.3969/j.issn.1006-0111.2019.03.002

陆顺超¹,
阎澜^2,

1.
海军军医大学基础医学院学员六大队学员十七队, 上海 200433
2.
海军军医大学药学院军特药研究中心, 上海 200433

Progress on anti-viral drugs and the application in military

LU Shunchao¹,
YAN Lan^2
,

1.
Company 17 of Cadet Battalion 6, College of Basic Medical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China
2.
Military Special Drug Research Center, School of Pharmacy, Naval Medical University, Shanghai 200433, China

摘要: 病毒感染威胁着人类健康，目前现有的抗病毒药物存在耐药性、毒副作用大等问题，因此，研发新型抗病毒药物仍是临床的迫切需求。针对多种不同抗病毒药物的研究和临床使用情况，根据药物不同的作用特点，分别介绍DNA多聚酶抑制剂、逆转录酶抑制剂、蛋白酶抑制剂、整合酶抑制剂、神经氨酸酶抑制剂、广谱抗菌药等临床常用及新型抗病毒药物，并简要介绍抗病毒药物在军事领域的应用。
- 抗病毒药物 /
- 免疫治疗 /
- 基因治疗
Abstract: Virus infection threatens human health.At present,the existing antiviral drugs have several problems including drug resistance and side effects.Thus,the study of new antiviral drugs has still become an urgent need in clinical practice.In this paper,some clinical commonly used and new antiviral drugs such as DNA polymerase inhibitor,reverse transcriptase inhibitor,protease inhibitor,integrase inhibitor,neuraminidase inhibitor,broad-spectrum antibacterial drugs and so on,were classified according to the different characteristics of antiviral drugs.This review also briefly introduced the application of antiviral drugs in military field.
- anti-viral drugs /
- immunotherapy /
- gene therapy

[1]	MARTINEZ J P,SASSE F,BRÖNSTRUP M M,et al.Antiviral drug discovery:broad-spectrum drugs from nature[J].Nat Prod Rep,2015,32(1):29-48.
[2]	WANG Y X,LI J X,HU Y M,et al.Ebola vaccines in clinical trial:the promising candidates[J].Human Vacc Immunother,2017,13(1):153-168.
[3]	杜红,赵柳红,覃忠于,等.HIV感染/AIDS住院患者高效抗逆转录病毒治疗中发生骨髓抑制致死亡的影响因素[J].中国药房,2015,26(35):4951-4954.
[4]	陈美钦,王长连.核苷类抗病毒药群体药动学研究及应用[J].海峡药学,2016,28(7):4-7.
[5]	DÉBORAH H,SAIK U,ELISABETH R,et al.Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates[J].Antimicrob Agent,2009,53(3):1067-1073.
[6]	ELION R,MOLINA J M,RAMN ARRIBAS LPEZ J,et al.A randomized phase 3 study comparing once-daily elvitegravir with twice-daily raltegravir in treatment-experienced subjects with HIV-1 infection[J].J AIDS,2013,63(4):494-497.
[7]	杨庆坤,龙燕,陈典颜,等.PEG-IFN α-2a和利巴韦林联合自拟中药复方治疗慢性丙型肝炎的临床疗效[J].重庆医学,2017,46(32):4533-4536.
[8]	戴兆东,经继生,赵伟.普通干扰素联合利巴韦林治疗1b型丙肝患者疗效分析[J].东南大学学报(医学版),2017,36(6):1002-1004.
[9]	KAMATA M,LIU S,LIANG M,et al.Generation of human induced pluripotent stem cells bearing an anti-HIV transgene by a lentiviral vector carrying an internal murine leukemia virus promoter[J].Human Gene Therap,2010,21(11):1555-1567.
[10]	REGULES J A,BEIGEL J H,PAOLINO K M,et al.A recombinant vesicular stomatitis virus Ebola vaccine[J].N Engl J Med,2017,376(4):330-341.
[11]	SHUCHMAN M.Ebola vaccine trial in west Africa faces criticism[J].Lancet,2015,385(9981):1933-1934.
[12]	Agnandji S T,Huttner A,Zinser M E,et al.Phase 1 trials of rVSV Ebola vaccine in Africa and Europe[J].N Engl J Med,2016,374(17):1647-1660.
[13]	MEDAGLINI D,HARANDI A M,OTTENHOFF T H M,et al.Ebola vaccine R&D:filling the knowledge gaps[J].Sci Transl Med,2015,7(317):317ps24.
[14]	FELDMANN H,JONES S M,DADDARIO-DICAPRIO K M,et al.Effective post-exposure treatment of Ebola infection[J].PLoS Pathogens,2007,3(1):e2.
[15]	JACOBS M,AARONS E,BHAGANI S,et al.Post-exposure prophylaxis against Ebola virus disease with experimental antiviral agents:a case-series of health-care workers[J].Lancet Infect Dis,2015,15(11):1300-1304.
[16]	LI A Z,YU J Y,LU M J,et al.A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein[J].Nat Commun,2018,9:3067.
[17]	李静,戎庭军,张铭键,等.TLR7的研究进展[J].浙江临床医学,2015(2):315-317.
[18]	HEMMI H,KAISHO T,TAKEUCHI O,et al.Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway[J].Nat Immunol,2002,3(2):196-200.
[19]	MARTIN H J,LEE J M,WALLS D,et al.Manipulation of the toll-like receptor 7 signaling pathway by epstein-barr virus[J].J Virol,2007,81(18):9748-9758.
[20]	SUNG J A,PATEL S,CLOHOSEY M L,et al.HIV-specific,Ex vivo expanded T cell therapy:feasibility,safety,and efficacy in ART-suppressed HIV-infected individuals[J].Molecul Ther,2018,26(10):2496-2506.
[21]	MENDOZA P,GRUELL H,NOGUEIRA L,et al.Combination therapy with anti-HIV-1 antibodies maintains viral suppression[J].Nature,2018,561(7724):479-484.
[22]	赵旭,周辛波,钟武,等.抗病毒药物——法匹拉韦[J].临床药物治疗杂志,2015,13(4):16-20.
[23]	SHI F,LI Z,KONG L,et al.Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide[J].Drug Discov Ther,2014,8(3):117-120.

[1]	柯刚, 董清科, 肖世容, 龚茜, 李荣, 汪代杰. 基于网络药理学探讨参苓白术散治疗肿瘤恶病质的作用机制 . 药学实践与服务, 2025, 43(5): 242-250. doi: 10.12206/j.issn.2097-2024.202208115
[2]	陈婷如, 顾秦五风, 吴芸杨, 孟园园, 杨延龙, 李睿旻. 中药外治法治疗湿疹引起皮肤瘙痒的Meta分析 . 药学实践与服务, 2025, 43(8): 383-389. doi: 10.12206/j.issn.2097-2024.202504013
[3]	高洁, 林心兰, 王兆骞, 张青亭, 李静静, 张凤. 生物制剂治疗强直性脊柱炎的研究进展 . 药学实践与服务, 2025, 43(7): 320-324. doi: 10.12206/j.issn.2097-2024.202502005
[4]	段禹, 刘爱军. 活血化瘀法治疗血管性痴呆的研究进展 . 药学实践与服务, 2025, 43(4): 151-155, 173. doi: 10.12206/j.issn.2097-2024.202408045
[5]	陈莹, 许子华, 胡北, 崔亚玲, 高欢, 吴琼. 通便灵胶囊治疗便秘的药效与机制研究 . 药学实践与服务, 2025, 43(1): 10-16. doi: 10.12206/j.issn.2097-2024.202404008
[6]	李锐, 张倩倩, 王瑞冬, 高小峰. 国家集中带量采购政策下样本医院良性前列腺增生治疗药物使用情况分析 . 药学实践与服务, 2025, 43(1): 41-46. doi: 10.12206/j.issn.2097-2024.202408031
[7]	陈明, 王晨佳, 唐原君, 汪硕闻, 范国荣. 新型靶向抗肿瘤药物呋喹替尼的治疗药物监测方法构建及其临床应用 . 药学实践与服务, 2025, 43(12): 1-4. doi: 10.12206/j.issn.2097-2024.202412043
[8]	邵明聪, 陈虎博, 张懿丹, 李梓嫣, 王丽娜. 乌头煎剂对小鼠RAW264.7巨噬细胞活性和极化的影响 . 药学实践与服务, 2025, 43(7): 329-334. doi: 10.12206/j.issn.2097-2024.202505043
[9]	魏莱, 董国强. SARS-CoV-2主蛋白酶抑制剂和降解剂研究进展 . 药学实践与服务, 2025, 43(6): 259-269, 297. doi: 10.12206/j.issn.2097-2024.202503064
[10]	魏莱, 董国强, 盛春泉. 靶向SARS-CoV-2主蛋白酶的PROTAC设计、合成与蛋白降解活性研究 . 药学实践与服务, 2025, 43(5): 235-241, 258. doi: 10.12206/j.issn.2097-2024.202503063
[11]	周娇, 郑建雨, 王思真, 杨峰. mRNA肿瘤疫苗非病毒递送系统研究进展 . 药学实践与服务, 2025, 43(3): 109-116. doi: 10.12206/j.issn.2097-2024.202410034
[12]	陈春娟, 郑志新, 李骊. 平喘方联合孟鲁司特钠治疗儿童支气管哮喘的临床疗效观察 . 药学实践与服务, 2024, 42(12): 524-527, 532. doi: 10.12206/j.issn.2097-2024.202405035
[13]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
[14]	张晶晶, 索丽娜, 郑兆红. 89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
[15]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[16]	孙丹倪, 黄勇, 张嘉宝, 王培. 代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
[17]	石晓萍, 吕迁洲, 李晓宇, 许青. 泊沙康唑对比伏立康唑经验治疗或诊断驱动治疗免疫功能低下患者侵袭性霉菌病的成本-效果分析 . 药学实践与服务, 2024, 42(12): 512-519. doi: 10.12206/j.issn.2097-2024.202401050
[18]	宋泽成, 陈林林, 鲁仁义, 刘梦肖, 王彦. 脓毒症治疗的研究进展 . 药学实践与服务, 2024, 42(11): 457-460, 502. doi: 10.12206/j.issn.2097-2024.202405059
[19]	唐淑慧, 凤美娟, 薛智霞, 鲁桂华. 帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
[20]	马兹芬, 许维恒, 金煜翔, 薛磊. 食管癌的靶向治疗与免疫治疗研究进展 . 药学实践与服务, 2024, 42(6): 231-237. doi: 10.12206/j.issn.2097-2024.202306008

点击查看大图

计量

文章访问数: 5307
HTML全文浏览量: 633
PDF下载量: 601
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

抗病毒药物研究进展及其在军事方面的应用

doi: 10.3969/j.issn.1006-0111.2019.03.002

Progress on anti-viral drugs and the application in military

计量

抗病毒药物研究进展及其在军事方面的应用

doi: 10.3969/j.issn.1006-0111.2019.03.002

1. 海军军医大学基础医学院学员六大队学员十七队, 上海 200433

2. 海军军医大学药学院军特药研究中心, 上海 200433

English Abstract

Progress on anti-viral drugs and the application in military

1. Company 17 of Cadet Battalion 6, College of Basic Medical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China

2. Military Special Drug Research Center, School of Pharmacy, Naval Medical University, Shanghai 200433, China

全文HTML

目录

留言板

抗病毒药物研究进展及其在军事方面的应用

doi: 10.3969/j.issn.1006-0111.2019.03.002

Progress on anti-viral drugs and the application in military

计量

出版历程

抗病毒药物研究进展及其在军事方面的应用

doi: 10.3969/j.issn.1006-0111.2019.03.002

1. 海军军医大学 基础医学院学员六大队学员十七队, 上海 200433 2. 海军军医大学 药学院军特药研究中心, 上海 200433

English Abstract

Progress on anti-viral drugs and the application in military

1. Company 17 of Cadet Battalion 6, College of Basic Medical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China 2. Military Special Drug Research Center, School of Pharmacy, Naval Medical University, Shanghai 200433, China

全文HTML

目录

1. 海军军医大学基础医学院学员六大队学员十七队, 上海 200433

2. 海军军医大学药学院军特药研究中心, 上海 200433

1. Company 17 of Cadet Battalion 6, College of Basic Medical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China

2. Military Special Drug Research Center, School of Pharmacy, Naval Medical University, Shanghai 200433, China