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细胞共培养模型在口服药物吸收研究中的应用

黎迎 朱春燕

黎迎, 朱春燕. 细胞共培养模型在口服药物吸收研究中的应用[J]. 药学实践与服务, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001
引用本文: 黎迎, 朱春燕. 细胞共培养模型在口服药物吸收研究中的应用[J]. 药学实践与服务, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001
LI Ying, ZHU Chunyan. Application of cell co-culture models in absorption of oral drug[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001
Citation: LI Ying, ZHU Chunyan. Application of cell co-culture models in absorption of oral drug[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001

细胞共培养模型在口服药物吸收研究中的应用

doi: 10.3969/j.issn.1006-0111.2015.04.001
基金项目: 国家自然科学基金面上项目(81274094);协和研究生创新基金项目(10023-1007-1017)

Application of cell co-culture models in absorption of oral drug

  • 摘要: 细胞共培养体系能很好地模拟人体小肠生理环境,准确预测药物在肠道内的转运和代谢情况,增强体外细胞模型与整体动物实验研究之间的相关性,近年来在评价口服药物吸收方面发挥着越发重要的作用,已成为新药研发过程中评价药物口服吸收的热点。综述体外模拟肠道环境的细胞共培养模型,并对其应用于口服药物研发的体外评价吸收做出展望。
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细胞共培养模型在口服药物吸收研究中的应用

doi: 10.3969/j.issn.1006-0111.2015.04.001
    基金项目:  国家自然科学基金面上项目(81274094);协和研究生创新基金项目(10023-1007-1017)

摘要: 细胞共培养体系能很好地模拟人体小肠生理环境,准确预测药物在肠道内的转运和代谢情况,增强体外细胞模型与整体动物实验研究之间的相关性,近年来在评价口服药物吸收方面发挥着越发重要的作用,已成为新药研发过程中评价药物口服吸收的热点。综述体外模拟肠道环境的细胞共培养模型,并对其应用于口服药物研发的体外评价吸收做出展望。

English Abstract

黎迎, 朱春燕. 细胞共培养模型在口服药物吸收研究中的应用[J]. 药学实践与服务, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001
引用本文: 黎迎, 朱春燕. 细胞共培养模型在口服药物吸收研究中的应用[J]. 药学实践与服务, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001
LI Ying, ZHU Chunyan. Application of cell co-culture models in absorption of oral drug[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001
Citation: LI Ying, ZHU Chunyan. Application of cell co-culture models in absorption of oral drug[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 289-292,327. doi: 10.3969/j.issn.1006-0111.2015.04.001
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