清蛋白作为药物载体的PEG化修饰研究进展

周琴琴; 陈建明

doi:10.3969/j.issn.1006-0111.2014.04.001

清蛋白作为药物载体的PEG化修饰研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.001

周琴琴¹,
陈建明^2,

1.
福建中医药大学药学院药物制剂教研室, 福建福州 350108;第二军医大学药学院药剂学教研室上海 200433
2.
第二军医大学药学院药剂学教研室上海 200433

Research advances of PEGylation modification of albumin as drug carrier

ZHOU Qinqin¹,
CHEN Jianming^2
,

1.
Department of Pharmaceutical Preparations, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 清蛋白(白蛋白)是一种理想的药物载体,但由于其在体内半衰期短以及易被酶降解等缺点限制了其应用,然而根据其具有多个修饰位点的结构特点,可通过PEG修饰延长循环时间,阻碍酶的作用等。目前,PEG修饰清蛋白仍处于研究阶段,已有较多关于PEG修饰清蛋白的研究,例如PEG修饰所起的作用、对清蛋白及其制剂的影响,以及修饰位点的选择等。本文对清蛋白的PEG化修饰的相关研究进行综述。
- 清蛋白 /
- PEG化 /
- 半衰期 /
- 药剂学性质 /
- 修饰位点
Abstract: Albumin is an ideal drug carrier, but its application was limited because of the shortcomings of short half-life and susceptible to enzymatic degradation in vivo.However, according to its structural features, albumin has a plurality of modification sites, which can be modified by PEG modifier to extend the cycle time and obstruct the action of the enzyme.Currently, the PEG-modified albumin is still in the research stage, and there have been many studies about PEG-modified albumin, such as the role of PEG modification, the effects on albumin and its preparations and the modification sites selection.The article reviewed the related studies about the PEGylation of albumin.
- albumin /
- PEGylation /
- half-life /
- pharmaceutical characterization /
- modification sites

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清蛋白作为药物载体的PEG化修饰研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.001

Research advances of PEGylation modification of albumin as drug carrier

计量

清蛋白作为药物载体的PEG化修饰研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.001

1. 福建中医药大学药学院药物制剂教研室, 福建福州 350108;第二军医大学药学院药剂学教研室上海 200433

2. 第二军医大学药学院药剂学教研室上海 200433

English Abstract

Research advances of PEGylation modification of albumin as drug carrier

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清蛋白作为药物载体的PEG化修饰研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.001

Research advances of PEGylation modification of albumin as drug carrier

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清蛋白作为药物载体的PEG化修饰研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.001

1. 福建中医药大学药学院药物制剂教研室, 福建 福州 350108;第二军医大学药学院药剂学教研室 上海 200433 2. 第二军医大学药学院药剂学教研室 上海 200433

English Abstract

Research advances of PEGylation modification of albumin as drug carrier

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目录

1. 福建中医药大学药学院药物制剂教研室, 福建福州 350108;第二军医大学药学院药剂学教研室上海 200433

2. 第二军医大学药学院药剂学教研室上海 200433