Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

2016 Vol. 34, No. 6

Cover
Display Method:
Cystine knot peptide's properties and its applications for drug design and molecular engineering
DENG Yuchen, GU Jiawei, NIE Fei, XIAO Liang
2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
Abstract(5225) PDF (341KB)(803)
Abstract:
The cystine knot (CK) motif comprises an internal ring formed by two disulfide bonds and their connecting backbone segments which is threaded by a third disulfide bond. It is present in peptides and proteins of a variety of species, including fungi, ...
Progress of the drug efflux mechanisms underlying fungi multidrug resistance
KANG Ye, ZHOU Mi, YAN Lan
2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
Abstract(3479) PDF (334KB)(1978)
Abstract:
The multidrug resistance (MDR), characterized by the simultaneous acquisition of resistance to chemically and structurally different drugs, has caused antifungal treatment failure. This review focused on recent progresses in understanding of the mult...
Advances in the nanotechnology-based drug delivery systems of salinomycin
ZHU Bing, SHENG Dandan, LI Shanxin, ZHANG Li
2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003
Abstract(3563) PDF (485KB)(1932)
Abstract:
Salinomycin, extensively used as an antibiotic in animal husbandry for a long time, has recently been found to possess strong anti-cancer and anti-cancer stem cell efficacy, as well as activities to overcome multi-drug resistance of tumor based on st...
Progress of tamsulosin hydrochloride sustained-release preparation
CHAI Peihua, ZHANG Tao, GAO Shen
2016, 34(6): 493-496. doi: 10.3969/j.issn.1006-0111.2016.06.004
Abstract(4098) PDF (332KB)(1439)
Abstract:
Tamsulosin hydrochloride is widely used for the treatment of lower urinary tract symptoms of benign prostatic hyperplasia, requiring long-term medication. It reduces adverse reactions of hypotension and dizziness by rapid absorption from oral intake....
Progress of pazopanib in clinical applications and adverse drug reaction
ZHOU Chenjian, ZHAO Langhuan, HU Guoxin
2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
Abstract(3866) PDF (256KB)(604)
Abstract:
Pazopanib is a multi-targeted tyrosine kinase inhibitor, and is mainly used to treat renal cell carcinoma, ovarian cancer, breast cancer, and lung cancer. The researchers also found that pazopanib may cause diarrhea, hypertension, hair loss, nausea, ...
Neuronal and endocrine regulation of food intake
SUN Yang, WANG Pengyuan, LIU Xia
2016, 34(6): 501-506,521. doi: 10.3969/j.issn.1006-0111.2016.06.006
Abstract:
The neuronal and hormonal regulations of food intake expand our knowledge about energy balance. The central nervous system integrates endocrine signals to regulate food intake and energy consumption. The nervous system and endocrine system interact w...
Effects of p-hydroxyacetophenone on bile secretion and blood lipid levels in rats
DENG Yifang, YU Pengxia, HUANG Xiaoling, HE Xingdong, YIN Ming, LIU Minyu
2016, 34(6): 507-510,525. doi: 10.3969/j.issn.1006-0111.2016.06.007
Abstract:
Objective To study the effects and mechanism of p-hydroxyacetophenone (PHA) on bile secretion, cholesterol metabolism and blood lipids. Methods Cystic duct cannula was cannulated and bile were collected in SD rats.PHA was administrated in the high...
Configuration inversion of C-2-hydroxy in lycorine
ZHAO Zeng, XU Xusheng, SUN Qingyan, CHEN Hao, LIU Runhui
2016, 34(6): 511-515. doi: 10.3969/j.issn.1006-0111.2016.06.008
Abstract(3143) PDF (5647KB)(1020)
Abstract:
Objective Study configuration inversion of C-2-hydroxy in lycorine to provide a foundation for semi-synthesis of asiaticumine B. Methods Use instrumental analyses to explore the C-2-hydroxy configuration through oxidation and reduction reactions. ...
Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.
ZENG Lingjun, KE Xiaowen, SONG Hongtao
2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
Abstract:
Objective To study and establish the extraction technology of hypoglycemic components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.. Methods Based on the singer factor test, the influences of extracting times, diameter of...
Quantitative analysis of isorhamnetin-3-rutinoside in leaves of Nitraria Spp. from Xinjiang region
JIANG Yiping, ZHANG Qiaoyan, FENG Ying, WANG Heng, WANG Qi, XIN Hailiang
2016, 34(6): 522-525. doi: 10.3969/j.issn.1006-0111.2016.06.010
Abstract(3594) PDF (437KB)(283)
Abstract:
Objective To provide supporting data for the quality control and evaluation of Nitraria Spp. from Xinjiang region by analyzing the content of isorhamnetin-3-rutinoside in its leaves. Methods HPLC method was used for the determination of isorhamnet...
Analysis of liposoluble chemicals from Achillea Alpina L. by GC-MS
LIANG Ruishu, XIONG Liyan, LI Ling, ZHANG Chuan
2016, 34(6): 526-529. doi: 10.3969/j.issn.1006-0111.2016.06.011
Abstract:
Objective To identify the chemical structures for the components in the liposoluble portion of Achillea alpina L. by gas chromatography/mass spectrometry (GC-MS). Methods Achillea alpina L. was extracted with 95% alcohol and petroleum ether. The c...
Study on quality control of Jianpibushen granules
XU Shaolan, ZHAO Dan, MAO Junqin
2016, 34(6): 530-533. doi: 10.3969/j.issn.1006-0111.2016.06.012
Abstract:
Objective To establish a quality standard for Jianpibushen granules. Methods The five main ingredients of the formulation:Astragalus membranaceus, Salvia miltiorrhiza Bunge, Codonopsis pilosula, Citrus reticulata Blanco and Paeonia lactiflora Pall...
Study on quality standards of hospital preparation Ganmao granules
JIN Weihua, YU Botao, CHEN Hua, ZHANG Ming, FAN Kaihua, PU Zhiqiang, SONG Zonghui
2016, 34(6): 534-536,551. doi: 10.3969/j.issn.1006-0111.2016.06.013
Abstract:
Objective To establish a quality standard for Ganmao granules of hospital preparations. Methods Radix Scutellariae, cortex phellodendri and radix bupleuri were identified by thin layer chromatography (TLC) qualitatively. High performance liquid ch...
Simultaneous determination of oleanolic acid and ursolic acid in Hawthorn extract by HPLC
MAO Ling, WEI Guobing, YE Ji, ZHOU Bailun, LIN Yinan
2016, 34(6): 537-539,555. doi: 10.3969/j.issn.1006-0111.2016.06.014
Abstract(3589) PDF (872KB)(729)
Abstract:
Objective To establish a HPLC method for simultaneous determination of oleanolic acid and ursolic acid and provide the basis for quality control of Hawthorn extract. Methods Chromatographic separation was performed on Agilent Zorbax SB C18 column(...
A systematic review on the correlation between selective dipeptidyl peptidase inhibitor vildagliptin and risk of arthralgia/osteoarthritis
TAO Yilin, HUANG Youming, LIN Huie
2016, 34(6): 540-545. doi: 10.3969/j.issn.1006-0111.2016.06.015
Abstract:
Objective To systematically evaluate the correlation between selective dipeptidyl peptidase (DPP)-4 inhibitor, vildagliptin and risk of arthralgia/osteoarthritis. Methods The following databases of PubMed (1978 to February 2016), the Cochrane Libr...
Quality assessment of systematic reviews/Meta-analyses correlated to levofloxacin for MDR-TB
WAN Suxin, HUANG Daoqiu, YU Lei, XIANG Yi, FANG Wei
2016, 34(6): 546-551. doi: 10.3969/j.issn.1006-0111.2016.06.016
Abstract:
Objective Assessing the publication and quality of systematic reviews/Meta-analyses correlated to levofloxacin for MDR-TB in China to promote the rational use of levofloxacin. Methods A literature retrieving was made in CNKI/VIP/WanFang Med-online...
A case analysis of conservative treatment of a cesarean scar pregnancy combined with uterine apoplexy
WU Yue, WANG Aihua, HAN Chaohong, FENG Xin
2016, 34(6): 552-555. doi: 10.3969/j.issn.1006-0111.2016.06.017
Abstract(3008) PDF (507KB)(336)
Abstract:
Objective To study the conservative treatment for cesarean scar pregnancy (CSP) with proper medications. Methods One case of CSP with uterine apoplexy was reported. Medication regimens were illustrated as the conservative treatments for the patien...
Analysis of biliary tract infections and anti-infection treatments on 101 cases of PTCD for malignant biliary obstruction
LI Yueyue, LIU Yi, LI Yanjun, CHEN Anni, WANG Hui, ZHAN Qi
2016, 34(6): 556-559,573. doi: 10.3969/j.issn.1006-0111.2016.06.018
Abstract(3471) PDF (954KB)(938)
Abstract:
Objective To find out the main pathogenic bacteria distribution and sensitivity to antibiotics in patients post PTCD for malignant biliary obstruction, to evaluate the therapeutic effectiveness of antibiotics and provide evidences for rational use o...
Clinical effects of continuous sequential therapy of femoston in 121 cases of menopausal syndrome
LOU Huiping, CHAI Suping, WANG Min
2016, 34(6): 560-562. doi: 10.3969/j.issn.1006-0111.2016.06.019
Abstract(5103) PDF (491KB)(1179)
Abstract:
Objective To explore the clinical efficacy and safety of continuous sequential hormone replacement therapy of femoston for menopausal syndrome. Methods 121 cases of menopausal syndrome at expert outpatient service in our hospital from January 2014...
Distribution of common pathogens and resistance analysis in a tertiary hospital
GONG Li, CHEN Wansheng, TAO Xia, HOU Xingyun
2016, 34(6): 563-566. doi: 10.3969/j.issn.1006-0111.2016.06.020
Abstract(3969) PDF (498KB)(397)
Abstract:
Objective To analyse the distribution of main pathogens and drug resistance in a tertiary hospital during 2014, and to provide the reference for the clinical rational use of antimicrobial agents. Methods Conventional methods were used for bacteria...
Utilization of narcotic drugs in outpatient and emergency pharmacy in a tertiary hospital
HUA Xiufang, ZHANG Bin
2016, 34(6): 567-569. doi: 10.3969/j.issn.1006-0111.2016.06.021
Abstract(3794) PDF (488KB)(299)
Abstract:
Objective To review the usage of narcotic drugs at outpatient and emergency pharmacy in order to promote rational narcotic drug use. Methods A total of 2 940 narcotic prescriptions from outpatient and emergency pharmacy in our hospital during Janu...
Drug use in the pediatric outpatient department of Ningbo Women & Children's Hospital
ZHOU Jing, YAN Yingyan, YAO Yunxi
2016, 34(6): 570-573. doi: 10.3969/j.issn.1006-0111.2016.06.022
Abstract(3287) PDF (499KB)(296)
Abstract:
Objective To investigate the drug use in the pediatric outpatient department of Ningbo Women & Children's Hospital, summarize the existing problems and analyze the causes in order to ensure the safety and effectiveness of the drug use. Methods A t...
The development of hospital preparation in the new health care reform environment
TAO Chun, SONG Hongtao
2016, 34(6): 574-576. doi: 10.3969/j.issn.1006-0111.2016.06.023
Abstract(3918) PDF (482KB)(447)
Abstract:
Objective To explore the development of hospital preparation under the domestic health care reform. Methods Research the ideas to further develop hospital preparation by analyzing the opportunities and challenges. Results The development of hosp...