Advances in the nanotechnology-based drug delivery systems of salinomycin

ZHU Bing; SHENG Dandan; LI Shanxin; ZHANG Li

doi:10.3969/j.issn.1006-0111.2016.06.003

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2016 > 34(6): 489-492,515

ZHU Bing, SHENG Dandan, LI Shanxin, ZHANG Li. Advances in the nanotechnology-based drug delivery systems of salinomycin[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003

Citation:

ZHU Bing, SHENG Dandan, LI Shanxin, ZHANG Li. Advances in the nanotechnology-based drug delivery systems of salinomycin[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 489-492,515. doi: 10.3969/j.issn.1006-0111.2016.06.003

Advances in the nanotechnology-based drug delivery systems of salinomycin

doi: 10.3969/j.issn.1006-0111.2016.06.003

1.
Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Department of Pharmacy, Hospital of No. 96263 Unit of PLA, Luoyang 471500, China
2.
Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

Received Date: 2016-03-03
Rev Recd Date: 2016-05-24

Abstract

Salinomycin, extensively used as an antibiotic in animal husbandry for a long time, has recently been found to possess strong anti-cancer and anti-cancer stem cell efficacy, as well as activities to overcome multi-drug resistance of tumor based on studies in vivo and in vitro in case reports in pilot clinical trials. Therefore, salinomycin promised to be a novel anti-cancer agent. However, the unfavorable property of poor aqueous solubility and the adverse effects of salinomycin were greatly hinder its clinical use. In order to improve its therapeutic index and alleviate its toxicity, studies on nanotechnology-based delivery systems of salinomycin had been widely conducted. In this article, the latest development and application of salinomycin nanoformulations were reviewed.
- salinomycin,
- nanoliposome,
- nanoparticle,
- nanomicelle

References

[1]	Gupta PB, Onder TT,Jiang GZ, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening[J]. Cell, 2009, 138(4):645-659.
[2]	Wang Y. Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells[J]. Med Chem, 2011, 7(2):106-111.
[3]	Dong TT, Zhou HM, Wang LL, et al. Salinomycin selectively targets CD133+ cell subpopulations and decreases malignant traits in colorectal cancer lines[J]. Ann Surg Oncol, 2011, 18(6):1797-1804.
[4]	Kim WK, Kim JH, Yoon K, et al. Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest[J]. Invest New Drugs, 2012, 30(4):1311-1318.
[5]	Huczynski A. Salinomycin:a new cancer drug candidate[J]. Chem Biol Drug Des, 2012, 79(3):235-238.
[6]	Ojo OO, Bhadauria S, Rath SK. Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice[J]. Plos One, 2013, 8(7):e69086.
[7]	Barenholz Y. Doxil-the first FDA-approved nano-drug:lessons learned[J]. J Control Release, 2012, 160(2):117-134.
[8]	巩志荣,何文婷,孙治国,等. 盐霉素钠纳米脂质体的制备及表征[J]. 药学实践杂志, 2015, 33(1):36-39.
[9]	Momekova D, Momekov G, Ivanova J, et al. Sterically stabilized liposomes as a platform for salinomycin metal coordination compounds:physicochemical characterization and in vitro evaluation[J]. J Drug Deliv Sci Technol, 2013, 23(3):215-223.
[10]	Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics:an emerging treatment modality for cancer[J]. Nat Rev Drug Discov, 2008, 7(9):771-782.
[11]	Ni M, Xiong M, Zhang X, et al. Poly (lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells[J]. Int J Nanomedicine, 2015, 10:2537-2554.
[12]	Jiang J, Chen H, Yu C, et al. The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles[J]. Nanomedicine, 2015, 10(12):1863-1879.
[13]	Zhao P, Dong S, Bhattacharyya J, et al. iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors[J]. Mol Pharm, 2014, 11(8):2703-2712.
[14]	Wang Q, Wu P, Ren W, et al. Comparative studies of salinomycin-loaded nanoparticles prepared by nanoprecipitation and single emulsion method[J]. Nanoscale Res Lett, 2014, 9(1):351-359.
[15]	Aydin RS. Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting[J]. J Biomed Mater Res A, 2013, 101(5):1405-1415.
[16]	Lei Y, Lai Y,Li Y, et al. Anticancer drug delivery of PEG based micelles with small lipophilic moieties[J]. Int J Pharm, 2013, 453(2):579-586.
[17]	毛骁丽, 张翮, 俞媛,等. 穿膜肽修饰盐霉素胶束的制备与表征[J]. 中国新药杂志, 2014, 23(23):2812-2816.
[18]	Wei T, Liu J, Ma H, et al. Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo[J]. Nano Letters, 2013, 13(6):2528-2534.
[19]	张杨, 代文兵, 王坚成,等. 载盐霉素聚合物胶束的构建与抗肿瘤干细胞的体外研究[J]. 中国药学杂志, 2014, 49(5):384-391.
[20]	Mao X, Liu J, Gong Z, et al. iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells[J]. Nanomedicine, 2015, 10(17):2677-2695.
[21]	Zhang Y, Zhang H, Wang X, et al. The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles[J]. Biomaterials, 2012, 33(2):679-691.
[22]	Wei X, Senanayake TH, Warren G, et al. Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors[J]. Bioconjug Chem, 2013, 24(4):658-668.
[23]	Fabbro C, Ali-Boucetta H, Da Ros T, et al. Targeting carbon nanotubes against cancer[J]. Chem Commun(Camb), 2012, 48(33):3911-3926.
[24]	Piovesan S, Cox PA, Smith JR, et al. Novel biocompatible chitosan decorated single-walled carbon nanotubes (SWNTs) for biomedical applications:theoretical and experimental investigations[J]. Phys Chem Chem Phys, 2010, 12(48):15636-15643.
[25]	Yao HJ, Zhang YG, Sun L, et al. The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells[J]. Biomaterials, 2014, 35(33):9208-9223.
[26]	Nystr m AM, Fadeel B. Safety assessment of nanomaterials:implications for nanomedicine[J]. J Control Release, 2012, 161(2):403-408.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Advances in the nanotechnology-based drug delivery systems of salinomycin

1. Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Department of Pharmacy, Hospital of No. 96263 Unit of PLA, Luoyang 471500, China

2. Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

Received Date: 2016-03-03

Rev Recd Date: 2016-05-24

Key words:

Abstract: Salinomycin, extensively used as an antibiotic in animal husbandry for a long time, has recently been found to possess strong anti-cancer and anti-cancer stem cell efficacy, as well as activities to overcome multi-drug resistance of tumor based on studies in vivo and in vitro in case reports in pilot clinical trials. Therefore, salinomycin promised to be a novel anti-cancer agent. However, the unfavorable property of poor aqueous solubility and the adverse effects of salinomycin were greatly hinder its clinical use. In order to improve its therapeutic index and alleviate its toxicity, studies on nanotechnology-based delivery systems of salinomycin had been widely conducted. In this article, the latest development and application of salinomycin nanoformulations were reviewed.

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Reference (26)

[1]	Gupta PB, Onder TT,Jiang GZ, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening[J]. Cell, 2009, 138(4):645-659.
[2]	Wang Y. Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells[J]. Med Chem, 2011, 7(2):106-111.
[3]	Dong TT, Zhou HM, Wang LL, et al. Salinomycin selectively targets CD133+ cell subpopulations and decreases malignant traits in colorectal cancer lines[J]. Ann Surg Oncol, 2011, 18(6):1797-1804.
[4]	Kim WK, Kim JH, Yoon K, et al. Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest[J]. Invest New Drugs, 2012, 30(4):1311-1318.
[5]	Huczynski A. Salinomycin:a new cancer drug candidate[J]. Chem Biol Drug Des, 2012, 79(3):235-238.
[6]	Ojo OO, Bhadauria S, Rath SK. Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice[J]. Plos One, 2013, 8(7):e69086.
[7]	Barenholz Y. Doxil-the first FDA-approved nano-drug:lessons learned[J]. J Control Release, 2012, 160(2):117-134.
[8]	巩志荣,何文婷,孙治国,等. 盐霉素钠纳米脂质体的制备及表征[J]. 药学实践杂志, 2015, 33(1):36-39.
[9]	Momekova D, Momekov G, Ivanova J, et al. Sterically stabilized liposomes as a platform for salinomycin metal coordination compounds:physicochemical characterization and in vitro evaluation[J]. J Drug Deliv Sci Technol, 2013, 23(3):215-223.
[10]	Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics:an emerging treatment modality for cancer[J]. Nat Rev Drug Discov, 2008, 7(9):771-782.
[11]	Ni M, Xiong M, Zhang X, et al. Poly (lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells[J]. Int J Nanomedicine, 2015, 10:2537-2554.
[12]	Jiang J, Chen H, Yu C, et al. The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles[J]. Nanomedicine, 2015, 10(12):1863-1879.
[13]	Zhao P, Dong S, Bhattacharyya J, et al. iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors[J]. Mol Pharm, 2014, 11(8):2703-2712.
[14]	Wang Q, Wu P, Ren W, et al. Comparative studies of salinomycin-loaded nanoparticles prepared by nanoprecipitation and single emulsion method[J]. Nanoscale Res Lett, 2014, 9(1):351-359.
[15]	Aydin RS. Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting[J]. J Biomed Mater Res A, 2013, 101(5):1405-1415.
[16]	Lei Y, Lai Y,Li Y, et al. Anticancer drug delivery of PEG based micelles with small lipophilic moieties[J]. Int J Pharm, 2013, 453(2):579-586.
[17]	毛骁丽, 张翮, 俞媛,等. 穿膜肽修饰盐霉素胶束的制备与表征[J]. 中国新药杂志, 2014, 23(23):2812-2816.
[18]	Wei T, Liu J, Ma H, et al. Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo[J]. Nano Letters, 2013, 13(6):2528-2534.
[19]	张杨, 代文兵, 王坚成,等. 载盐霉素聚合物胶束的构建与抗肿瘤干细胞的体外研究[J]. 中国药学杂志, 2014, 49(5):384-391.
[20]	Mao X, Liu J, Gong Z, et al. iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells[J]. Nanomedicine, 2015, 10(17):2677-2695.
[21]	Zhang Y, Zhang H, Wang X, et al. The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles[J]. Biomaterials, 2012, 33(2):679-691.
[22]	Wei X, Senanayake TH, Warren G, et al. Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors[J]. Bioconjug Chem, 2013, 24(4):658-668.
[23]	Fabbro C, Ali-Boucetta H, Da Ros T, et al. Targeting carbon nanotubes against cancer[J]. Chem Commun(Camb), 2012, 48(33):3911-3926.
[24]	Piovesan S, Cox PA, Smith JR, et al. Novel biocompatible chitosan decorated single-walled carbon nanotubes (SWNTs) for biomedical applications:theoretical and experimental investigations[J]. Phys Chem Chem Phys, 2010, 12(48):15636-15643.
[25]	Yao HJ, Zhang YG, Sun L, et al. The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells[J]. Biomaterials, 2014, 35(33):9208-9223.
[26]	Nystr m AM, Fadeel B. Safety assessment of nanomaterials:implications for nanomedicine[J]. J Control Release, 2012, 161(2):403-408.

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Advances in the nanotechnology-based drug delivery systems of salinomycin

doi: 10.3969/j.issn.1006-0111.2016.06.003

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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