ZHAO Zeng, XU Xusheng, SUN Qingyan, CHEN Hao, LIU Runhui. Configuration inversion of C-2-hydroxy in lycorine[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 511-515. doi: 10.3969/j.issn.1006-0111.2016.06.008
| Citation:
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ZHAO Zeng, XU Xusheng, SUN Qingyan, CHEN Hao, LIU Runhui. Configuration inversion of C-2-hydroxy in lycorine[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 511-515. doi: 10.3969/j.issn.1006-0111.2016.06.008
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Configuration inversion of C-2-hydroxy in lycorine
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Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2016-04-16
- Rev Recd Date:
2016-06-21
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Abstract
Objective Study configuration inversion of C-2-hydroxy in lycorine to provide a foundation for semi-synthesis of asiaticumine B. Methods Use instrumental analyses to explore the C-2-hydroxy configuration through oxidation and reduction reactions. Results Accomplished configuration inversion of C-2-hydroxy in lycorine with 49% yield. Conclusion We identified a convenient and efficient method for the configuration inversion of C 2-hydroxy in lycorine.
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