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Volume 34 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(6): 516-521

ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
Citation: ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
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Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.

doi: 10.3969/j.issn.1006-0111.2016.06.009

  • Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China

  • Received Date: 2015-10-20
  • Rev Recd Date: 2016-04-28
  • Objective To study and establish the extraction technology of hypoglycemic components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.. Methods Based on the singer factor test, the influences of extracting times, diameter of drug powder, soaking time, solid-liquid ratio, ethanol concentration, and extracting time on extraction ratio of total flavonoids were studied. The best extraction technology of total flavonoids from Gynura divaricata (L.) DC. was established through L9(3)4 orthogonal tests. On the base of previous studies combine with L9(3)4 orthogonal tests, the best extraction technology of total polysaccharides from Gynura divaricata (L.) DC. was established. Results The optimized extraction technology of total flavonoids was confirmed as follows:drug powder of less than 10 mesh diameter were soaking 0.5 hour with 80% ethanol, and solid-liquid ratio 1:20, and extracting twice, each time one hour. The optimized extraction technology of total polysaccharides was confirmed as follows:add 20 times water to the residue of ethanol, extraction temperature 90℃, and extracting twice, each time one hour. The extraction rate of both total flavonoids and polysaccharides were more than 80%. Conclusion The extraction technology of hypoglycemic components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC. established in this study is stable, reproducible, and lays a foundation for the further studies on hypoglycemic components in Gynura divaricata (L.) DC.
  • [1] 黄有霖. 福建省中药材标准[S]. 福建:海风出版社,2006:70-73.
    [2] 胡勇,李维林,林厚文,等. 白背三七地上部分降血糖作用研究[J]. 西南林学院学报,2007,27(1):54-58.
    [3] 姜曼花,胡剑卓,邱文高,等. 白背三七多糖和黄酮降血糖及耐缺氧作用[J]. 中国医院药学杂志,2009,29(13):1074-1076.
    [4] 马正东,陈磊,宋洪涛,等. 白背三七水提取物对2型糖尿病大鼠的降血糖作用及其机制[J]. 中草药,2010,41(4):623-626.
    [5] 俞浩,毛斌斌,周国梁,等. 白背三七总黄酮对糖尿病大鼠的降血糖作用[J]. 食品科学,2013,34(15):295-298.
    [6] 张钱钱. 白子草多糖的分离纯化及其降血糖作用研究[D]. 福建:福建中医药大学,2014.
    [7] 王津江,陈磊,宋洪涛,等. 白背三七总黄酮的提取工艺研究[J]. 中国药师,2009,12(2):146-149.
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Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.

doi: 10.3969/j.issn.1006-0111.2016.06.009
  • Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China
  • Received Date: 2015-10-20
  • Rev Recd Date: 2016-04-28

Abstract: Objective To study and establish the extraction technology of hypoglycemic components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.. Methods Based on the singer factor test, the influences of extracting times, diameter of drug powder, soaking time, solid-liquid ratio, ethanol concentration, and extracting time on extraction ratio of total flavonoids were studied. The best extraction technology of total flavonoids from Gynura divaricata (L.) DC. was established through L9(3)4 orthogonal tests. On the base of previous studies combine with L9(3)4 orthogonal tests, the best extraction technology of total polysaccharides from Gynura divaricata (L.) DC. was established. Results The optimized extraction technology of total flavonoids was confirmed as follows:drug powder of less than 10 mesh diameter were soaking 0.5 hour with 80% ethanol, and solid-liquid ratio 1:20, and extracting twice, each time one hour. The optimized extraction technology of total polysaccharides was confirmed as follows:add 20 times water to the residue of ethanol, extraction temperature 90℃, and extracting twice, each time one hour. The extraction rate of both total flavonoids and polysaccharides were more than 80%. Conclusion The extraction technology of hypoglycemic components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC. established in this study is stable, reproducible, and lays a foundation for the further studies on hypoglycemic components in Gynura divaricata (L.) DC.

ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
Citation: ZENG Lingjun, KE Xiaowen, SONG Hongtao. Study on extraction technology of blood glucose-lowering components of total flavonoids and polysaccharides from Gynura divaricata (L.) DC.[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 516-521. doi: 10.3969/j.issn.1006-0111.2016.06.009
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