2017 Vol. 35, No. 1
Display Method:
2017, 35(1): 1-5,16.
doi: 10.3969/j.issn.1006-0111.2017.01.001
Abstract:
Baphicacanthus cusia, widely distributed in the Southwest, Southern and Eastern regions of China, is an important medicinal plant of Acanthaceae family. Indigo made from stem and leaf of Baphicacanthus cusia in Fujian has the best quality in China, a...
Baphicacanthus cusia, widely distributed in the Southwest, Southern and Eastern regions of China, is an important medicinal plant of Acanthaceae family. Indigo made from stem and leaf of Baphicacanthus cusia in Fujian has the best quality in China, a...
2017, 35(1)
doi: 10.3969/j.issn.1006-0111.2017.01.002
Abstract:
Organoselenium compounds are bioactive substances with extensive physiological activities. As a representative compound, ebselen could be used as mimics of glutathione peroxidase, and in the treatment of many diseases, such as cardiovascular and cere...
Organoselenium compounds are bioactive substances with extensive physiological activities. As a representative compound, ebselen could be used as mimics of glutathione peroxidase, and in the treatment of many diseases, such as cardiovascular and cere...
2017, 35(1): 8-11.
doi: 10.3969/j.issn.1006-0111.2017.01.003
Abstract:
People do have some risks of exposing to the radiation during their daily life.Longtime or megadose ionizing radiation can induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc..Currently, more and more radio protec...
People do have some risks of exposing to the radiation during their daily life.Longtime or megadose ionizing radiation can induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc..Currently, more and more radio protec...
2017, 35(1): 12-16.
doi: 10.3969/j.issn.1006-0111.2017.01.004
Abstract:
Objective To synthesize a series of 13-acylmatrine derivatives and evaluate their in vitro antitumor activity. Methods Using sophocarpine as the starting material,a series of new compounds were synthesized through Michael addition,Staudinger reduct...
Objective To synthesize a series of 13-acylmatrine derivatives and evaluate their in vitro antitumor activity. Methods Using sophocarpine as the starting material,a series of new compounds were synthesized through Michael addition,Staudinger reduct...
2017, 35(1): 17-21,86.
doi: 10.3969/j.issn.1006-0111.2017.01.005
Abstract:
Objective Based on the structure-activity relationships on the reported antifungal agents bearing quinoline or thiophene moieties, novel compounds bearing both quinoline and thiophene were designed, synthesized, and evaluated for in vitro antifungal...
Objective Based on the structure-activity relationships on the reported antifungal agents bearing quinoline or thiophene moieties, novel compounds bearing both quinoline and thiophene were designed, synthesized, and evaluated for in vitro antifungal...
2017, 35(1): 22-25,59.
doi: 10.3969/j.issn.1006-0111.2017.01.006
Abstract:
Objective To design and synthesize novel triazole antifungal derivatives with 1,3,4-oxadiazole side chain for the study of antifungal activities. Methods Fourteen title compounds were synthesized via acylation, aminolysis reaction, cyclization, nuc...
Objective To design and synthesize novel triazole antifungal derivatives with 1,3,4-oxadiazole side chain for the study of antifungal activities. Methods Fourteen title compounds were synthesized via acylation, aminolysis reaction, cyclization, nuc...
2017, 35(1): 26-30,35.
doi: 10.3969/j.issn.1006-0111.2017.01.007
Abstract:
Objective To design and prepare 13,15-cycloimides chlorin p6 ( 1 ),a class of chlorin related antitumor photosensitizers,which contain a more stable six-membered cyclic imide comparing to the exocyclic anhydride ring of purpurin-18 ( 2 ). Compounds ...
Objective To design and prepare 13,15-cycloimides chlorin p6 ( 1 ),a class of chlorin related antitumor photosensitizers,which contain a more stable six-membered cyclic imide comparing to the exocyclic anhydride ring of purpurin-18 ( 2 ). Compounds ...
2017, 35(1): 31-35.
doi: 10.3969/j.issn.1006-0111.2017.01.008
Abstract:
Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets. Methods The nimodipine as a model drug, micronization technique was applied to the PPOP method. Designed and prepared the controlled release of the...
Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets. Methods The nimodipine as a model drug, micronization technique was applied to the PPOP method. Designed and prepared the controlled release of the...
2017, 35(1): 36-38,66.
doi: 10.3969/j.issn.1006-0111.2017.01.009
Abstract:
Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle ...
Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle ...
2017, 35(1): 39-42.
doi: 10.3969/j.issn.1006-0111.2017.01.010
Abstract:
Objective To utilize and evaluate the resources of Abrus cantoniensis Hance (AC) and Abrus mollis Hance (AM) by analyzing and comparing their essential oils and fatty acids. Method The essential oils of AC and AM were extracted with the hydro disti...
Objective To utilize and evaluate the resources of Abrus cantoniensis Hance (AC) and Abrus mollis Hance (AM) by analyzing and comparing their essential oils and fatty acids. Method The essential oils of AC and AM were extracted with the hydro disti...
2017, 35(1): 43-47,53.
doi: 10.3969/j.issn.1006-0111.2017.01.011
Abstract:
Objective To confirm the hepatotoxicity of valproic acid (VPA) and its metabolites(2-propyl-4-pentenoic acid, 3-hydroxy valproic acid, 5-hydroxy valproic acid) on human liver cells. Methods Cells were divided into control group and VPA-treated grou...
Objective To confirm the hepatotoxicity of valproic acid (VPA) and its metabolites(2-propyl-4-pentenoic acid, 3-hydroxy valproic acid, 5-hydroxy valproic acid) on human liver cells. Methods Cells were divided into control group and VPA-treated grou...
2017, 35(1): 48-53.
doi: 10.3969/j.issn.1006-0111.2017.01.012
Abstract:
Objective To explore the feasibility of bletilla striata polysaccharide as a drug delivery material. Method With hydrophobic cholesterol succinyl bletilla striata polysaccharide (CHSB) as the carrier, the model drug paclitaxel (PTX) loaded nanopart...
Objective To explore the feasibility of bletilla striata polysaccharide as a drug delivery material. Method With hydrophobic cholesterol succinyl bletilla striata polysaccharide (CHSB) as the carrier, the model drug paclitaxel (PTX) loaded nanopart...
2017, 35(1): 54-59.
doi: 10.3969/j.issn.1006-0111.2017.01.013
Abstract:
Objective Risk management is one of the strong measurements to ensure the conduction of new drug research and development (R&D) projects. Therefore, establishing a set of evaluation index system in the new drug R&D projects is of great significance ...
Objective Risk management is one of the strong measurements to ensure the conduction of new drug research and development (R&D) projects. Therefore, establishing a set of evaluation index system in the new drug R&D projects is of great significance ...
2017, 35(1): 60-63,69.
doi: 10.3969/j.issn.1006-0111.2017.01.014
Abstract:
Objective To establish a HPLC method for the assay of cyproheptadine hydrochloride and the related substances. Methods The HPLC was performed on an Agilent Eclipse XDB-C18 column (4.6 mm×250 mm, 5 μm) at the temperature of 25℃ with the mobile phase...
Objective To establish a HPLC method for the assay of cyproheptadine hydrochloride and the related substances. Methods The HPLC was performed on an Agilent Eclipse XDB-C18 column (4.6 mm×250 mm, 5 μm) at the temperature of 25℃ with the mobile phase...
2017, 35(1): 64-66.
doi: 10.3969/j.issn.1006-0111.2017.01.015
Abstract:
Objective To develop a HPLC method for determination of baicalin. Methods The separation was carried out on a Waters XBridge C18 column(4.6 mm×250 mm, 5 μm), the mobile phase was composed of acetonitrile and 0.8% formic acid (25:75), the detection ...
Objective To develop a HPLC method for determination of baicalin. Methods The separation was carried out on a Waters XBridge C18 column(4.6 mm×250 mm, 5 μm), the mobile phase was composed of acetonitrile and 0.8% formic acid (25:75), the detection ...
2017, 35(1): 67-69.
doi: 10.3969/j.issn.1006-0111.2017.01.016
Abstract:
Objective To determine the quercetin content in Folium Apocyni Veneti from different commercial markets and harvest time by HPLC. Methods The determination was performed on an Aglient Eclipse XDB-C18 column (250 mm×4.6 mm,5 μm)at 30℃ with a mobile ...
Objective To determine the quercetin content in Folium Apocyni Veneti from different commercial markets and harvest time by HPLC. Methods The determination was performed on an Aglient Eclipse XDB-C18 column (250 mm×4.6 mm,5 μm)at 30℃ with a mobile ...
2017, 35(1): 70-72.
doi: 10.3969/j.issn.1006-0111.2017.01.017
Abstract:
Objective To discuss the evaluation method of anti-infective therapy by clinical pharmacist. Methods Anti-infection therapy for an AECOPD patient in department of respiration in our hospital was analyzed to discuss the evaluation method of anti- in...
Objective To discuss the evaluation method of anti-infective therapy by clinical pharmacist. Methods Anti-infection therapy for an AECOPD patient in department of respiration in our hospital was analyzed to discuss the evaluation method of anti- in...
2017, 35(1): 73-74,81.
doi: 10.3969/j.issn.1006-0111.2017.01.018
Abstract:
Objective To investigate the analgesia effects of dynastat in hepatic cancer patients after liver resection. Methods From June to December of year 2015, we collected 200 cases of hepatic cancer operation in the Eastern Hepatobiliary Surgery Hospita...
Objective To investigate the analgesia effects of dynastat in hepatic cancer patients after liver resection. Methods From June to December of year 2015, we collected 200 cases of hepatic cancer operation in the Eastern Hepatobiliary Surgery Hospita...
2017, 35(1): 75-77.
doi: 10.3969/j.issn.1006-0111.2017.01.019
Abstract:
Objective To evaluate the effects of fentanyl transdermal combined with morphine subcutaneous injection in the management of advanced liver cancer pain after intervention. Methods 166 patients who suffered from advanced liver cancer and received in...
Objective To evaluate the effects of fentanyl transdermal combined with morphine subcutaneous injection in the management of advanced liver cancer pain after intervention. Methods 166 patients who suffered from advanced liver cancer and received in...
2017, 35(1): 78-81.
doi: 10.3969/j.issn.1006-0111.2017.01.020
Abstract:
Objective To review the package inserts of children's common antineoplastic agents in Shanghai, identify problems, and seek countermeasures. Methods Reference summarizing and data analysis were used. Results The labeling rate of dosage for childre...
Objective To review the package inserts of children's common antineoplastic agents in Shanghai, identify problems, and seek countermeasures. Methods Reference summarizing and data analysis were used. Results The labeling rate of dosage for childre...
2017, 35(1): 82-86.
doi: 10.3969/j.issn.1006-0111.2017.01.021
Abstract:
Objective To evaluate the efficacy and safety of amrubicin for small-cell lung cancer(SCLC). Methods PubMed, Embase, the Cochrane Library and CNKI were searched to collect amrubicin data in the treatment of SCLC. A Meta-analysis was performed over ...
Objective To evaluate the efficacy and safety of amrubicin for small-cell lung cancer(SCLC). Methods PubMed, Embase, the Cochrane Library and CNKI were searched to collect amrubicin data in the treatment of SCLC. A Meta-analysis was performed over ...
2017, 35(1): 87-88,93.
doi: 10.3969/j.issn.1006-0111.2017.01.022
Abstract:
Objective To understand outpatient's attention and comprehension to package insert in the grassroots hospital. Methods 608 outpatients were randomly selected to answer the questionnaires designed with relevant data. Results Patients paid the highe...
Objective To understand outpatient's attention and comprehension to package insert in the grassroots hospital. Methods 608 outpatients were randomly selected to answer the questionnaires designed with relevant data. Results Patients paid the highe...
2017, 35(1): 89-93.
doi: 10.3969/j.issn.1006-0111.2017.01.023
Abstract:
Objective To investigate how the clinical pharmacists participate in the regime design and adjustment in the treatment of infectious disease and to show how clinical pharmacists to team with physicians for patient's infection control by contributing...
Objective To investigate how the clinical pharmacists participate in the regime design and adjustment in the treatment of infectious disease and to show how clinical pharmacists to team with physicians for patient's infection control by contributing...
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