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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(1): 75-77

ZHU Hengmei, LU Guihua, FANG Shuheng, XU Lili. Pain Management with fentanyl transdermal and morphine subcutaneous injection for the patients with advanced liver cancer pain after intervention therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 75-77. doi: 10.3969/j.issn.1006-0111.2017.01.019
Citation: ZHU Hengmei, LU Guihua, FANG Shuheng, XU Lili. Pain Management with fentanyl transdermal and morphine subcutaneous injection for the patients with advanced liver cancer pain after intervention therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 75-77. doi: 10.3969/j.issn.1006-0111.2017.01.019
shu

Pain Management with fentanyl transdermal and morphine subcutaneous injection for the patients with advanced liver cancer pain after intervention therapy

doi: 10.3969/j.issn.1006-0111.2017.01.019
  • 1.

    Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

  • 2.

    Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2016-06-27
  • Rev Recd Date: 2016-10-10
  • Objective To evaluate the effects of fentanyl transdermal combined with morphine subcutaneous injection in the management of advanced liver cancer pain after intervention. Methods 166 patients who suffered from advanced liver cancer and received intervention therapy in our hospital were divided into two groups. 89 patients belong to the fentanyl transdermal combined with morphine subcutaneous injection treatment group. 77 patients belong to the morphine subcutaneous injection treatment group. The pain score and the remission rate of the two groups were compared and analyzed statistically. Meanwhile, the side effects of each group were recorded. Results Pain score in the group with fentanyl transdermal and morphine treatment was significantly lower than morphine mono therapy. 12 hours after intervention therapy, (1.97±0.56 for combination treatment vs 3.23±1.49 for morphine only group, P<0.05). 24 hours after intervention therapy, (1.63±0.44 for combination vs 4.19±1.68 for morphine only group, P<0.01). Similarly, the remission rate of the fentanyl transdermal combined with morphine subcutaneous injection group improved significantly, (92.1% vs 76.6% P<0.05) 12 hours after intervention therapy, and(97.8% vs 70.1%, P<0.05) 24 hours after intervention therapy. Conclusions The addition of fentanyl transdermal to morphine subcutaneous injection treatment significantly improve the pain remission rate for the patients with advanced liver cancer pain 72 hours after intervention therapy.
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    [9] 赵春玲,张新,陈洪华,等.芬太尼透皮贴剂治疗晚期癌症患者疼痛的临床观察及护理[J].护理研究,2004,18(18):153.
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    2. 苏瑛. 丙泊酚联合芬太尼用于肝癌微波消融术的效果评价. 中西医结合心血管病电子杂志. 2020(17): 169+172 .
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    7. 唐凤英，张锋利，吴洁琼，相祎，张伟，高二鹏. 黛力新与芬太尼透皮贴剂联用对原发性肝癌患者焦虑及抑郁心理的影响. 国际精神病学杂志. 2018(04): 718-721 .
    8. 何玉婷. 芬太尼透皮贴剂联合吗啡皮下注射在晚期肝癌介入术后疼痛护理的应用. 黑龙江医药科学. 2018(01): 119+121 .
    9. 刘唱，姜玺玉，王宇菲. 综合护理干预在中西医结合治疗肝癌疼痛中的实施效果研究. 中西医结合心血管病电子杂志. 2017(12): 78 .

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Pain Management with fentanyl transdermal and morphine subcutaneous injection for the patients with advanced liver cancer pain after intervention therapy

doi: 10.3969/j.issn.1006-0111.2017.01.019
  • 1. Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
  • 2. Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2016-06-27
  • Rev Recd Date: 2016-10-10

Abstract: Objective To evaluate the effects of fentanyl transdermal combined with morphine subcutaneous injection in the management of advanced liver cancer pain after intervention. Methods 166 patients who suffered from advanced liver cancer and received intervention therapy in our hospital were divided into two groups. 89 patients belong to the fentanyl transdermal combined with morphine subcutaneous injection treatment group. 77 patients belong to the morphine subcutaneous injection treatment group. The pain score and the remission rate of the two groups were compared and analyzed statistically. Meanwhile, the side effects of each group were recorded. Results Pain score in the group with fentanyl transdermal and morphine treatment was significantly lower than morphine mono therapy. 12 hours after intervention therapy, (1.97±0.56 for combination treatment vs 3.23±1.49 for morphine only group, P<0.05). 24 hours after intervention therapy, (1.63±0.44 for combination vs 4.19±1.68 for morphine only group, P<0.01). Similarly, the remission rate of the fentanyl transdermal combined with morphine subcutaneous injection group improved significantly, (92.1% vs 76.6% P<0.05) 12 hours after intervention therapy, and(97.8% vs 70.1%, P<0.05) 24 hours after intervention therapy. Conclusions The addition of fentanyl transdermal to morphine subcutaneous injection treatment significantly improve the pain remission rate for the patients with advanced liver cancer pain 72 hours after intervention therapy.

ZHU Hengmei, LU Guihua, FANG Shuheng, XU Lili. Pain Management with fentanyl transdermal and morphine subcutaneous injection for the patients with advanced liver cancer pain after intervention therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 75-77. doi: 10.3969/j.issn.1006-0111.2017.01.019
Citation: ZHU Hengmei, LU Guihua, FANG Shuheng, XU Lili. Pain Management with fentanyl transdermal and morphine subcutaneous injection for the patients with advanced liver cancer pain after intervention therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 75-77. doi: 10.3969/j.issn.1006-0111.2017.01.019
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