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Volume 35 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(1): 31-35

CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
Citation: CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
shu

Preparation of micronized nimodipine push-pull osmotic pump tablets

doi: 10.3969/j.issn.1006-0111.2017.01.008

  • Shanxi Provincial People's Hospital, Taiyuan 030012, China

  • Received Date: 2015-08-25
  • Rev Recd Date: 2016-05-03
  • Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets. Methods The nimodipine as a model drug, micronization technique was applied to the PPOP method. Designed and prepared the controlled release of the nimodipine tablet for 12 hours in vitro. The factor f2 was used to evaluate the similarities of different dissolution profiles, and the optimal formulation was performed. Results The micronized nimodipine PPOP controlled release tablets were successfully prepared with excellent zero-order release characteristics. The PPOP tablet's release behavior was close to the zero-order release equation (r=0.998 4). Conclusions The controlled-release formulation was prepared successfully. Micronized technique combined with the PPOP method significantly increased the release of the nimodipine tablet, the poorly soluble drug, in vitro.
  • [1] Thombre AG,Appel LE,Chidlaw M,et al.Osmotic drug delivery using swellable-core technology[J].J Control Release,2004, 94(1):75-89.
    [2] Langley MS,Sorkin EM.Nimodipine:a view of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in cerebra vascular disease[J].Drugs,1989,37(5):669-699.
    [3] 姜红,金少红.固体药物制剂的溶出度比较[J].中国药事,2000,14(5):326-328.
    [4] 夏锦辉,刘昌孝.固体药物制剂的体外溶出度的统计学评价分析[J].中国药学杂志,2000,35(2):130-131.
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Preparation of micronized nimodipine push-pull osmotic pump tablets

doi: 10.3969/j.issn.1006-0111.2017.01.008
  • Shanxi Provincial People's Hospital, Taiyuan 030012, China
  • Received Date: 2015-08-25
  • Rev Recd Date: 2016-05-03

Abstract: Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets. Methods The nimodipine as a model drug, micronization technique was applied to the PPOP method. Designed and prepared the controlled release of the nimodipine tablet for 12 hours in vitro. The factor f2 was used to evaluate the similarities of different dissolution profiles, and the optimal formulation was performed. Results The micronized nimodipine PPOP controlled release tablets were successfully prepared with excellent zero-order release characteristics. The PPOP tablet's release behavior was close to the zero-order release equation (r=0.998 4). Conclusions The controlled-release formulation was prepared successfully. Micronized technique combined with the PPOP method significantly increased the release of the nimodipine tablet, the poorly soluble drug, in vitro.

CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
Citation: CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
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