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2011 Vol. 29, No. 4

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Application of chemometrics in the optimization of extraction conditions and prescription formulations in pharmaceutical preparations
WANG Li-li, SHI Sen-lin
2011, 29(4): 241-246,255.
Abstract(2740) PDF (909KB)(479)
Abstract:
Objective To illustrate the importance of chemometrics tools (experimental design combined with modeling and optimization) in the study on pharmaceutical preparations. Methods A wide range of publications associated with extraction condition and pres...
Progress on the study of toxicologic biomarkers in digestive system
WANG Jie, XIA Zhen-na, CHE Ai-ping, YUAN Bo-jun, LU Guo-cai
2011, 29(4): 247-250.
Abstract(2995) PDF (860KB)(443)
Abstract:
Toxicologic biomarkers,indicating specific toxic effects, are biological changes of body when exposured to toxic doses of chemicals. Comprehensive assessment and clinical application of toxicologic biomarkers at early stage could effectively reduce t...
Research on the anti-fertility activity of natural products
QI Jing-jing, ZHEN Can-hui, LV Jia-guo
2011, 29(4): 251-255.
Abstract(3442) PDF (982KB)(334)
Abstract:
Objective Natural products had been demonstrated with significant and extremely potent biological activities, which could provide useful leading compounds for new drug research. In recent years , it was one of the hotspots for the family planning dru...
Advances of metabolic engineering in lignin biosynthesis
HU Yong-sheng, XIAO Ying, DI Peng, ZHANG Lei, CHEN Wan-sheng
2011, 29(4): 256-259,271.
Abstract(2938) PDF (951KB)(1010)
Abstract:
Objective To introduce advances of metabolic engineering in lignin biosynthesis. Methods The structure of lignin, biosynthesis, systems biology and new metabolic engineering strategies were reviewed. Results & Conclusions Lignin was a phenolic polyme...
Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words]
FAN Yong-zheng, ZHANG Chen, CHEN Zhen-xing, LIU Jun-jie, LU Ying, ZHONG Yan-qiang, ZOU Hao
2011, 29(4): 260-262,268.
Abstract(3091) PDF (908KB)(749)
Abstract:
Objective To develop a new type of chewing gum contained caffeine, and a method for determination of caffeine in the chewing gum. Methods the caffeine powder and sugar powder were mixed evenly. the mixtures were reconciled with the chewing gum which ...
Study on quality control standard of changkang keli
LIU Lu, FU Cong
2011, 29(4): 263-264,280.
Abstract(3066) PDF (943KB)(517)
Abstract:
Objective To establish the quality standard for changkang keli. Methods Coptidis rhizome , mume fructus were identified by TLC. The content of berberine hydrochloride was determined by HPLC. Results Coptidis rhizome, mume fructus could be identified ...
Study on transfection efficiency mediated by the complexes of lipoplexes and anionic liposomes
SUN Ji, CHEN Yan, LU Ying, ZHONG Yan-qiang
2011, 29(4): 265-268.
Abstract(2890) PDF (917KB)(510)
Abstract:
Objective To evaluate the efficiency of different complexes of lipoplexes and anionic liposomes which mediated gene transfection to hepatoma cells(HepG2). Methods Cationic liposomes encapsulating report gene were prepared by reverse-evaporation metho...
Determination of Wilforlide in Tripterygium wilfordii multi-glucoside microemulsion by RP-HPLC
WANG Zhi-jun, YOU Ben-ming, SUN Hua-jun, SONG Hong-jie, LIU Ji-yong
2011, 29(4): 269-271.
Abstract(2523) PDF (877KB)(320)
Abstract:
Objective To develop a RP-HPLC method for the determination of Wilforlide in Tripterygium wilfordii multi-glucoside microemulsion. Methods The separation was performed on a Kromasil ODS C18 analytical column (150 mm×4.6 mm, 5μm) with the mobile phase...
Experimental study on the antidepressant activities of Isoquercitrin
ZHANG Li-bin, ZHANG Xiao-qing, LI Yu-ping
2011, 29(4): 272-273,290.
Abstract(3059) PDF (878KB)(372)
Abstract:
Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The...
Composition and anti-inflammatory activities of essential oils from Gentiana crassicaulis and Gentiana scabra
HE Xi-rui, LI Mao-xing, SHANG Xiao-fei, JIA Zheng-ping, ZHANG Ru-xue
2011, 29(4): 274-277,283.
Abstract(3672) PDF (938KB)(333)
Abstract:
Objective To study the anti-inflammatory activities of essential oils from the roots of G. crassicaulis Duthie ex Burkand G. scabra Bunge in vivo and in vitro. Methods The essential oils were extracted by supercritical fluid extraction (SFE), and the...
Determination of Chlorogenic acid in Qingrexiaozhong oral liquid by HPLC
SUN Xue-xiong, LUO Chen-qu
2011, 29(4): 278-280.
Abstract(2957) PDF (871KB)(427)
Abstract:
Objective To develop a HPLC method for determining the content of Chlorogenic acid in QingRexiaozhong Oral Liquid. Methods The phenomenex Luna-C18(200 mm×4.60 mm ,5 μm)was used ;the mobile phase consisted of water-1%Acetic acid (20:80),the flow rate ...
Evaluation of measurement uncertainty method for determination of Ceftriaxone by HPLC
DU Zhen
2011, 29(4): 281-283.
Abstract(2480) PDF (870KB)(361)
Abstract:
Objective To evaluate the uncertainty of measurement for determination of Ceftriaxone by HPLC. Methods The content of Ceftriaxone was determined by HPLC .The mathematical model was established to analyze the source of uncertaint. Results Every compon...
Chemical constituents of Ampelopsis japonica(Thunb.) Makino
LIU Qing-bo, LI Fei, LIU Jia, SONG Yan-zhi, ZHONG Li-li
2011, 29(4): 284-284,314.
Abstract(3259) PDF (871KB)(535)
Abstract:
Objective To isolate and identify the compounds from the Ampelopsis japonica(Thunb.) Makino. Methods The compounds were separated and purified by column chromatography and their structures were established by spectroscopic methods. Results Seven comp...
Study on the chemical constituents of Cortex Meliae
YAN Ying, HUANG Chen
2011, 29(4): 285-286,317.
Abstract(3203) PDF (901KB)(468)
Abstract:
Objective To study the chemical constituents of Cortex Meliae. Methods Chromatographic techniques were employed to isolate and purify the chemical constituents of Cortex Meliae. Structures of the chemical constituents were elucidated by methods of IR...
Study on chemical constituents in Rubus corchorifolius
WU Mei-Yu
2011, 29(4): 287-290.
Abstract(3053) PDF (909KB)(801)
Abstract:
Objective To study the chemical constituents in Rubus corchorifolius. Methods Chromatography on silica gel column,Sephadex LH-20 columm,recrystallization and preparative HPLC technique were used to isolate and purify the compounds.Spectroscopy method...
Analysis on the irrational use of anti-infective drugs in the department of osteology
YU Wei, ZHANG Shu-rong, ZUO Guo-ying
2011, 29(4): 291-293,295.
Abstract(2618) PDF (859KB)(812)
Abstract:
Objective To provide theory bases for further interference aiming at clinical using drugs rationally. Methods in order to find out and evaluate the main manifestations of clinical inconsequence use of anti- infective drugs, the records of typical irr...
2011, 29(4): 294-295.
Abstract(2319) PDF (822KB)(538)
Abstract:
Conception and charging mode of medicine service fee
ZHOU Xiao-ming
2011, 29(4): 296-297,303.
Abstract(3144) PDF (849KB)(411)
Abstract:
In 2009,the new health care system reform formally proposed a medicine service fee as one of the compensation means for cancelling drug price addition in hospital. But, the people of all circles had different understanding of medicine service fee and...
Prescription evaluation of Cefepime injection in the emergency
ZHAO Na-ping, WANG Jing, WANG Zhuo, YANG Zhang-wei, ZHANG Li
2011, 29(4): 298-299,320.
Abstract(2705) PDF (860KB)(382)
Abstract:
Objective To discuss the method and process of prescription evaluation and establish evaluation process of rational utility of antimicrobial drug in the emergency. Methods The prescribing information and emergency medical information of Cefepime hydr...
Analysis and countermeasure of outpatient and emergency drug return in our hospital
LIN Fu-lin, PANG Su-qiu
2011, 29(4): 300-303.
Abstract(2584) PDF (836KB)(376)
Abstract:
Objective To strengthen administration and reduce drug return through analyzing the outpatient and emergency drug return. Methods The data of 220 cases of drug return from October of 2009 to July of 2010 were analyzed statistically. Results The main ...
The application of EpiData Entry-EpiData Analysis software in pharmacy information management
YING Yin, ZHENG Zao-qian, SHI Jia-na
2011, 29(4): 304-305.
Abstract(3213) PDF (879KB)(343)
Abstract:
Objective To facilitate the application of EpiData software in pharmacy information management. Methods Epidata Entry was used to record pharmacy information data.The logging data and process were controlled by editing check files. Then the data were...
Survey of similarity of drug trade names and registered trade names
DONG Zhao-hua, SHEN Jia-jie, ZHANG Yi-han, SUN Hua-jun
2011, 29(4): 306-308,311.
Abstract(2759) PDF (874KB)(456)
Abstract:
Objective To describe the factors of confusions between drug trade names and drug registered names that might lead to medication errors. Methods Drug trade names data are collected from the shared database at State Food and Drug Administration websit...
Problems and suggestions on supervision of traditional Chinese health food market in Shanghai
ZHANG Guang-ren, WANG Xiao-guang, FU Yan-feng, JIANG Guo-hua, JI Feng, HUANG Bao-kang
2011, 29(4): 309-311.
Abstract(2650) PDF (845KB)(410)
Abstract:
To analyze the problem and status of the health food market in Shanghai. Suggestions on the safety and supervision of edible traditional Chinese medicine were given to promote the health food market.
Improvement of experimental teaching in pharmaceutics by pilotscale preparation experiments
CHEN Yan, LU Ying, ZHAO Ping, ZHANG He, YU Yuan, LI Guo-dong, SUN Zhi-guo, ZOU Hao, ZHONG Yan-qiang
2011, 29(4): 312-314.
Abstract(2663) PDF (846KB)(501)
Abstract:
Objective To improve students' comprehensive practical ability of pharmacy by experiments reformation. Methods Based on the chemical synthesis and pharmacology experiments, the experiments of Acetylsalicylic Acid Tables in production, quality standar...
Experience on reformation of the experiment for the prediction of drug validity duration and drug stability
WANG Xiu-xin, XU Wei-heng, ZHU Zhang-chao, ZHU Zhan-zhou, CHEN Jian-ming
2011, 29(4): 315-317.
Abstract(2892) PDF (845KB)(398)
Abstract:
To reform the experiment for the prediction of drug validity duration and drug stability. A new teaching model was established. The traditional experiment scheme was improved, which achieved good results, so as to train pharmacy undergraduate student...
Application of the teaching sssistants system in organic chemistry teaching
HU Hong-gang, ZOU Yan, ZHAO Qing-jie, SUN Qing-yan, JIN Yong-sheng, ZHANG Da-zhi, WU Qiu-ye
2011, 29(4): 318-320.
Abstract(2551) PDF (828KB)(452)
Abstract:
Teaching assistant (TA) mode had been broadly applied in the educational process in the university of western countries. The author had joined the TA program in organic chemistry course in USA. How to manage teaching assistants mode to improving the ...