2011 Vol. 29, No. 3
Display Method:
2011, 29(3): 161-164.
Abstract:
Molecularly imprinted polymer drawn much attention for its specific identification function. Among all the research about MIPS, drug separation takes a large proportion. MIPS played an important role in extracting the target-drug from mixture, separating structure analogues and chiral drug, which enhanced the position of MIPS in the field of drug separation. In this paper, the research of MIPS in drug separation and the choice of MIPS functional monomer had been summarized, and the development direction in the future had also been predicted.
Molecularly imprinted polymer drawn much attention for its specific identification function. Among all the research about MIPS, drug separation takes a large proportion. MIPS played an important role in extracting the target-drug from mixture, separating structure analogues and chiral drug, which enhanced the position of MIPS in the field of drug separation. In this paper, the research of MIPS in drug separation and the choice of MIPS functional monomer had been summarized, and the development direction in the future had also been predicted.
2011, 29(3): 165-168.
Abstract:
With the deepening research of gene therapy, to find an efficient, safe, targeted expression gene vector had become one of the core issues of gene therapy. Poly amino ester (PAE) as a new type of cationic polymer gene carriers, with cheap raw materials, simple synthesis, diversity structure, biodegradability, low toxicity and high efficiency transfection, which had attracted lots of researchers' focus. Recent research of PAE as a gene vector from the poly amino ester synthesis pathway, physical and chemical properties, properties of poly amino ester / DNA nano-particles and transfection efficiency of polyamino ester/DNA nano-particles were summarized in this paper.
With the deepening research of gene therapy, to find an efficient, safe, targeted expression gene vector had become one of the core issues of gene therapy. Poly amino ester (PAE) as a new type of cationic polymer gene carriers, with cheap raw materials, simple synthesis, diversity structure, biodegradability, low toxicity and high efficiency transfection, which had attracted lots of researchers' focus. Recent research of PAE as a gene vector from the poly amino ester synthesis pathway, physical and chemical properties, properties of poly amino ester / DNA nano-particles and transfection efficiency of polyamino ester/DNA nano-particles were summarized in this paper.
2011, 29(3): 169-172,192.
Abstract:
Objective To summarize the recent advances in oral sustained/controlled release pellets in international and domestic and prospect its developing future. Methods A great quantity of references were comprehensively reviewed. Results Various kinds of information of oral sustained/controlled release pellets including the characteristic,excipients,preparation methods and squash technique were summarized. Conclusions Pellets as multiple-unit drug delivery system have many advantages.With preparation techniques and excipient materials were gradually developed,pellets would play an important part in the development of sustained/controlled release drug delivery system.
Objective To summarize the recent advances in oral sustained/controlled release pellets in international and domestic and prospect its developing future. Methods A great quantity of references were comprehensively reviewed. Results Various kinds of information of oral sustained/controlled release pellets including the characteristic,excipients,preparation methods and squash technique were summarized. Conclusions Pellets as multiple-unit drug delivery system have many advantages.With preparation techniques and excipient materials were gradually developed,pellets would play an important part in the development of sustained/controlled release drug delivery system.
2011, 29(3): 173-175,216.
Abstract:
Citrulline was more and more widely used in food and drug industry, health products industry and cosmetics industry because of it's particular pharmacological effects. At present, there were four main methods for producing citrulline: chemical method, extraction method, enzymatic and fermentation method. The pharmacological effects, the application and research current situation about citrulline were summarized in home and abroad. The development prospects of citrulline were predicted.
Citrulline was more and more widely used in food and drug industry, health products industry and cosmetics industry because of it's particular pharmacological effects. At present, there were four main methods for producing citrulline: chemical method, extraction method, enzymatic and fermentation method. The pharmacological effects, the application and research current situation about citrulline were summarized in home and abroad. The development prospects of citrulline were predicted.
2011, 29(3): 176-178,196.
Abstract:
The delivery of chemotherapeutics with targeted nanoparticles in anticancer therapy was a rapidly growing area of research. The advantages of targeted nanoparticles for drug delivery include water solubility increasement, tumor-specific accumulation and antitumor efficacy improvement, and nonspecific toxicity reduction. Current research in this field focused on understanding precisely how small molecules were released from nanoparticles and deliver to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. The existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field were discussed in this paper.
The delivery of chemotherapeutics with targeted nanoparticles in anticancer therapy was a rapidly growing area of research. The advantages of targeted nanoparticles for drug delivery include water solubility increasement, tumor-specific accumulation and antitumor efficacy improvement, and nonspecific toxicity reduction. Current research in this field focused on understanding precisely how small molecules were released from nanoparticles and deliver to the targeted tumor tissues or cells, and how the unique biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. The existing nanoparticles for the delivery of small-molecule anticancer agents and recent advances in this field were discussed in this paper.
2011, 29(3): 179-180,211.
Abstract:
Ischemia-reperfusion injury was a complex course in pathophysiology with many factors which had been implicated in the pathogenesis of a variety of clinical conditions including liver transplantation, and liver resectional surgery. The mechanism of ischemia-reperfusion injury and medication cure ways for ischemia-reperfusion injury were investigated in this paper.
Ischemia-reperfusion injury was a complex course in pathophysiology with many factors which had been implicated in the pathogenesis of a variety of clinical conditions including liver transplantation, and liver resectional surgery. The mechanism of ischemia-reperfusion injury and medication cure ways for ischemia-reperfusion injury were investigated in this paper.
2011, 29(3): 181-183.
Abstract:
Depression was a common mental disease, which seriously threat people's health. The treatment of depression had become the focus. The present situation of the diagnostic criteria and treatment by integration of traditional and western medicine was introduced.
Depression was a common mental disease, which seriously threat people's health. The treatment of depression had become the focus. The present situation of the diagnostic criteria and treatment by integration of traditional and western medicine was introduced.
2011, 29(3): 184-187,203.
Abstract:
Objective To investigate the efficacy of Shenmai injection combined TE chemotherapy regime in the treatment of breast cancer and the influence to the quality of life in breast cancer patient. Methods 22 patients with pathologically confirmed advanced breast cancer aged from 34 to 72 were randomly divided into experimental group (TE plus Shenmai injection treatment group) and the control group (only with TE chemotherapy group). The efficacy ,side effects and blood indices were observed and analyzed. All patients received two or more cycles of treatment. SPSS10.0 statistical software was used to statistical analysis. Results 22 cases could be evaluated.The effective rate of treatment group (CR+PR) was 54.55%, and the rate of control group was 63.64%. There was no significant difference between two groups (P>0.05); clinical benefit rate was 81.82% in treatment group, and 72.73% in control group, which had no significant difference between groups (P>0.05). The main adverse events in both groups were from the blood system. compared with the control group, which had statistically significant (P<0.05) between two groups. Other adverse reactions had the similar incidence in two groups and had not statistically significant (P>0.05). Conclusion TE Shenmai injection in the treatment of breast cancer was effective and well tolerated, plus Shenmai injection could improve the quality of life in cancer patients, reduce the chemotherapy-induced hematological toxicity and non-hematologic toxicity.
Objective To investigate the efficacy of Shenmai injection combined TE chemotherapy regime in the treatment of breast cancer and the influence to the quality of life in breast cancer patient. Methods 22 patients with pathologically confirmed advanced breast cancer aged from 34 to 72 were randomly divided into experimental group (TE plus Shenmai injection treatment group) and the control group (only with TE chemotherapy group). The efficacy ,side effects and blood indices were observed and analyzed. All patients received two or more cycles of treatment. SPSS10.0 statistical software was used to statistical analysis. Results 22 cases could be evaluated.The effective rate of treatment group (CR+PR) was 54.55%, and the rate of control group was 63.64%. There was no significant difference between two groups (P>0.05); clinical benefit rate was 81.82% in treatment group, and 72.73% in control group, which had no significant difference between groups (P>0.05). The main adverse events in both groups were from the blood system. compared with the control group, which had statistically significant (P<0.05) between two groups. Other adverse reactions had the similar incidence in two groups and had not statistically significant (P>0.05). Conclusion TE Shenmai injection in the treatment of breast cancer was effective and well tolerated, plus Shenmai injection could improve the quality of life in cancer patients, reduce the chemotherapy-induced hematological toxicity and non-hematologic toxicity.
2011, 29(3): 188-192.
Abstract:
Objective To study the anti-myocardial ischemia effect of Yixintong. Methods The rat myocardial ischemia model was caused by isoprenaline and the experiment myocardial infraction dogs were used to observe the effect of Yixintong. Blood stasis model was used to observe the effect of Yixintong on blood viscosity and platelet aggregation. Results Yixintong (0.4 g/kg, 0.2 g/kg)could decrease ST length and rise serum enzyme(such as AST,CPK and LDH). Yixintong (0.4 g/kg,0.2 g/kg) could also lower the blood viscosity. Yixintong could improve hemorrheologic abnormality and lower the whole blood viscosity. Yixintong could inhibit platelet aggregation of rat. Yixintong could ameliorate the myocardial ischemia degree(Σ-ST) and decrease the myocardial ischemia coverage(N-ST). Yixintong could also decrease the rised serum enzyme(such as AST,CPK and LDH). Conclusions Yixintong had a protective and therapeutic action to the experimental myocardial ischemia.
Objective To study the anti-myocardial ischemia effect of Yixintong. Methods The rat myocardial ischemia model was caused by isoprenaline and the experiment myocardial infraction dogs were used to observe the effect of Yixintong. Blood stasis model was used to observe the effect of Yixintong on blood viscosity and platelet aggregation. Results Yixintong (0.4 g/kg, 0.2 g/kg)could decrease ST length and rise serum enzyme(such as AST,CPK and LDH). Yixintong (0.4 g/kg,0.2 g/kg) could also lower the blood viscosity. Yixintong could improve hemorrheologic abnormality and lower the whole blood viscosity. Yixintong could inhibit platelet aggregation of rat. Yixintong could ameliorate the myocardial ischemia degree(Σ-ST) and decrease the myocardial ischemia coverage(N-ST). Yixintong could also decrease the rised serum enzyme(such as AST,CPK and LDH). Conclusions Yixintong had a protective and therapeutic action to the experimental myocardial ischemia.
2011, 29(3): 193-196.
Abstract:
Objective To synthetize and conduct PTP1B inhibitory activity experiment of series of novel mangiferin derivates. Methods Different benzyl groups were introduced to mangiferin framework by nucleophilic substitution reaction. All the compounds were screened against protein tyrosine phosphatase 1B(PTP1B)with the colorimetrie assay. Results Eight compounds were synthesized and all the compounds exhibited PTP1B inhibitory activity to some extent. Conclusions Derivates of mangiferin remarkably enhanced the activity compared with mangiferin itself. In addition, the benzylated derivates with chloro atom had better inhibitory activity than other substitution groups. Furthermore,the para position of the benzyl was a better place for introducing substituent than meta and ortho position.
Objective To synthetize and conduct PTP1B inhibitory activity experiment of series of novel mangiferin derivates. Methods Different benzyl groups were introduced to mangiferin framework by nucleophilic substitution reaction. All the compounds were screened against protein tyrosine phosphatase 1B(PTP1B)with the colorimetrie assay. Results Eight compounds were synthesized and all the compounds exhibited PTP1B inhibitory activity to some extent. Conclusions Derivates of mangiferin remarkably enhanced the activity compared with mangiferin itself. In addition, the benzylated derivates with chloro atom had better inhibitory activity than other substitution groups. Furthermore,the para position of the benzyl was a better place for introducing substituent than meta and ortho position.
2011, 29(3): 197-199,231.
Abstract:
Objective To study the density of the dissolved oxygen(DO) on fermentation of E.coli in producing rhG-CSF. Methods Pure oxygen was used to control DO precisely and to observe the growth of engineered bacteria, the lost of plasmids ,the accumulation of acetic acid from different DO density. The optimum density of DO for fermentation was determined. Results 25% in growth phase and 30% after induction was optimum density of DO for rhG-CSF expression and engineered bacteria growth. Under these conditions, the wet cell weight reached(79.6±2.1) g/L and the expression of rhG-CSF was(40.2±1.2)%. Conclusions The growth of engineered bacteria and the expression of rhG-CSF were influenced by the density of dissolved oxygen significantly.
Objective To study the density of the dissolved oxygen(DO) on fermentation of E.coli in producing rhG-CSF. Methods Pure oxygen was used to control DO precisely and to observe the growth of engineered bacteria, the lost of plasmids ,the accumulation of acetic acid from different DO density. The optimum density of DO for fermentation was determined. Results 25% in growth phase and 30% after induction was optimum density of DO for rhG-CSF expression and engineered bacteria growth. Under these conditions, the wet cell weight reached(79.6±2.1) g/L and the expression of rhG-CSF was(40.2±1.2)%. Conclusions The growth of engineered bacteria and the expression of rhG-CSF were influenced by the density of dissolved oxygen significantly.
2011, 29(3): 200-203.
Abstract:
Objective To determination isofraxidin, rosmarinic acid and astilbin content in different artifical cultivated Herba Sarcandrae. Methods Test sample were classified by plant ports of above and below ground ,and determine by HPLC. A Zorbax SB-C18 column was used, with the mobile phase of CH3CN-0.1%H3PO4 (20:80)and CH3CN-0.1%H3PO4(90:10). The gradient elution; detection wavelength was 330 nm and 290nm. Results The content of isofraxidin, rosmarinic acid and astilbin content in different artifical cultivated Herba Sarcandrae and different parts of Sarcandrae were quite different. Conclusion Determination of isofraxidin, rosmarinic acid and astilbin content ,could fully reflect the quality of Sarcandrae. The experimental area of artifical cultivated Sarcandrae have good quality; plant part above ground have a high medicinal value.
Objective To determination isofraxidin, rosmarinic acid and astilbin content in different artifical cultivated Herba Sarcandrae. Methods Test sample were classified by plant ports of above and below ground ,and determine by HPLC. A Zorbax SB-C18 column was used, with the mobile phase of CH3CN-0.1%H3PO4 (20:80)and CH3CN-0.1%H3PO4(90:10). The gradient elution; detection wavelength was 330 nm and 290nm. Results The content of isofraxidin, rosmarinic acid and astilbin content in different artifical cultivated Herba Sarcandrae and different parts of Sarcandrae were quite different. Conclusion Determination of isofraxidin, rosmarinic acid and astilbin content ,could fully reflect the quality of Sarcandrae. The experimental area of artifical cultivated Sarcandrae have good quality; plant part above ground have a high medicinal value.
2011, 29(3): 204-205,218.
Abstract:
Objective To evaluate the efficacy of indometacin in treatment of pain syndrome related to radiation-induced mucositis. Methods Fifty-eight cases of head and neck malignancies with radio-therapeutic mucositis pain were randomly divided into two groups: one group were treated with both indometacin and normal therapy, the other group received normal therapy. Results By using the indometacin, the pain relief rate during the radiotherapy was 89.7%, which was 27.6% in control group. In the treatment group, the body weight stable ratio in radiation and after radiation are 69.0% and 37.9%, which was 34.5% and 17.2% in control group. The chief side effects were reduced. Conclusion Indometacin could relieve pain with radio-therapeutic mucositis pain in radiotherapy to head and neck malignancies treated and should be further evaluated prospectively in controlled clinical trials.
Objective To evaluate the efficacy of indometacin in treatment of pain syndrome related to radiation-induced mucositis. Methods Fifty-eight cases of head and neck malignancies with radio-therapeutic mucositis pain were randomly divided into two groups: one group were treated with both indometacin and normal therapy, the other group received normal therapy. Results By using the indometacin, the pain relief rate during the radiotherapy was 89.7%, which was 27.6% in control group. In the treatment group, the body weight stable ratio in radiation and after radiation are 69.0% and 37.9%, which was 34.5% and 17.2% in control group. The chief side effects were reduced. Conclusion Indometacin could relieve pain with radio-therapeutic mucositis pain in radiotherapy to head and neck malignancies treated and should be further evaluated prospectively in controlled clinical trials.
2011, 29(3): 206-207,234.
Abstract:
Objective To determine the active position of Bletilla colloid and offer references to the seleciton of its active composition. Methonds The crude Bletilla colloid was extracted by 70% ethanol permeating , then the petroleum ether extract,ethyl acetate exctract ,n-butyl alcohol extract and water extract were exctracted from alcohol extract in turn by petroleum,ethyl acetate,n-butyl alcohol extraction. The active position was determined by measuring the time of mice blood coagulation and hemorrhage. Results N-butanol extract and water extract from Bletilla colloid had hemostasis effect,ethyl acetate extract had the effect of prolonging the time of blood coagulation and hemorrhage. Conclusion N-butanol extract and water extract from Bletilla colloid was major active extracts played a part in hemostasis, ethyl acetate extract had the effect of invigoration the circulation of blood.
Objective To determine the active position of Bletilla colloid and offer references to the seleciton of its active composition. Methonds The crude Bletilla colloid was extracted by 70% ethanol permeating , then the petroleum ether extract,ethyl acetate exctract ,n-butyl alcohol extract and water extract were exctracted from alcohol extract in turn by petroleum,ethyl acetate,n-butyl alcohol extraction. The active position was determined by measuring the time of mice blood coagulation and hemorrhage. Results N-butanol extract and water extract from Bletilla colloid had hemostasis effect,ethyl acetate extract had the effect of prolonging the time of blood coagulation and hemorrhage. Conclusion N-butanol extract and water extract from Bletilla colloid was major active extracts played a part in hemostasis, ethyl acetate extract had the effect of invigoration the circulation of blood.
Effects of grape seed procyanidins on spatial learning and memory in vascular dementia model of rats
2011, 29(3): 208-211.
Abstract:
Objective To investigate the effects and possible mechanisms of procyanidins, a polyphenol extracted from grape seeds, on spatial learning and memory in rats model of vascular dementia(VD). Methods Modified Pulsinelli's 4-vessel occlusion (4-VO) method was used for replicating vascular dementia in rats. The male Wistar rats were divided equally into 5 experimental groups: in one the rats were subjected to sham-operated, and in the other four the rats was subjected to the 4-VO surgery followed by oral administration of vehicle, Ginkgo leaf extract(24 mg/kg), procyanidins(50 or 150 mg/kg) respectively. The spatial learning and memory performance was recorded as the acquisition trial and probe trial in the Morris water maze. The levels of malondialdehyde(MDA), glutathione(GSH), total antioxidant capacity(T-AOC) and the activity of superoxidedismutase(SOD) in the brain tissue were determined by colorimetric Assay Kit. The gene expression of Bax and Bcl-2 in the rat hippocampus was detected by real-time PCR. Results The vascular dementia rats treated with procyanidins showed decreased escaped latency during acquisition training, especially at the dose of 150 mg/kg, procyanidins also increased exploration time and frequency of crossing in the target quadrant during probe trial. The administration of procyanidins induced increase in GSH, T-AOC contents and SOD activities with lowering MDA levels in the brain. In addition, procyanidins upregulated the Bcl-2/Bax ratio of mRNA expression in the rat hippocampus. Conclusion Procyanidins could have potentials for improving the spatial cognition with VD,which was possibly due to the antioxidative and anti-apoptotic effects of polyphenol.
Objective To investigate the effects and possible mechanisms of procyanidins, a polyphenol extracted from grape seeds, on spatial learning and memory in rats model of vascular dementia(VD). Methods Modified Pulsinelli's 4-vessel occlusion (4-VO) method was used for replicating vascular dementia in rats. The male Wistar rats were divided equally into 5 experimental groups: in one the rats were subjected to sham-operated, and in the other four the rats was subjected to the 4-VO surgery followed by oral administration of vehicle, Ginkgo leaf extract(24 mg/kg), procyanidins(50 or 150 mg/kg) respectively. The spatial learning and memory performance was recorded as the acquisition trial and probe trial in the Morris water maze. The levels of malondialdehyde(MDA), glutathione(GSH), total antioxidant capacity(T-AOC) and the activity of superoxidedismutase(SOD) in the brain tissue were determined by colorimetric Assay Kit. The gene expression of Bax and Bcl-2 in the rat hippocampus was detected by real-time PCR. Results The vascular dementia rats treated with procyanidins showed decreased escaped latency during acquisition training, especially at the dose of 150 mg/kg, procyanidins also increased exploration time and frequency of crossing in the target quadrant during probe trial. The administration of procyanidins induced increase in GSH, T-AOC contents and SOD activities with lowering MDA levels in the brain. In addition, procyanidins upregulated the Bcl-2/Bax ratio of mRNA expression in the rat hippocampus. Conclusion Procyanidins could have potentials for improving the spatial cognition with VD,which was possibly due to the antioxidative and anti-apoptotic effects of polyphenol.
2011, 29(3): 212-213.
Abstract:
Objective To establish a method to determinate dimeticone in type Ⅱ silicone gel by Infrared spectrophotometry. Methods The infrared spectrophotometry was adopted, and the detective wave was 1 262 cm-1. Results The linear range of the calibration of dimeticone was 0.409~2.863 mg/ml (r=0.999 9), the average recovery was 100.13%, RSD=1.02% (n=6). Conclusion The method was accurate, realizable which could be used to determinate dimeticone in type Ⅱ silicone gel.
Objective To establish a method to determinate dimeticone in type Ⅱ silicone gel by Infrared spectrophotometry. Methods The infrared spectrophotometry was adopted, and the detective wave was 1 262 cm-1. Results The linear range of the calibration of dimeticone was 0.409~2.863 mg/ml (r=0.999 9), the average recovery was 100.13%, RSD=1.02% (n=6). Conclusion The method was accurate, realizable which could be used to determinate dimeticone in type Ⅱ silicone gel.
2011, 29(3): 214-216.
Abstract:
Objective To separate and identify the components in Danxiangguanxin injection by high performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOFMS). Methods Agilent Zorbax SB-Cl8 column (3.0 mm×100 mm, 3.5 μm) was used for separation and identification of chemical components in Danxiangguanxin injection with a mobile phase of 0.5 % acetic acid (A) and acetonitrile (B) in gradient elution. 0~25 min, 2%~33% B; 25~30 min, 33%~95% B; the flowing rate was 0.5 ml/min and the injection volume was 5 μl. And the time-of-flight mass spectrometer was equipped with an EIS ion source. Scanning mass range was ranged between m/z 100~1000. Results Thirty-one chemical compounds in Danxiangguanxin injection were identified unequivocally. Conclusion Chromatographic demonstration of chemical compounds in Danxiangguanxin injection could provide foundation for the further metabolism and action mechanism study of Danxiangguanxin injection.
Objective To separate and identify the components in Danxiangguanxin injection by high performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOFMS). Methods Agilent Zorbax SB-Cl8 column (3.0 mm×100 mm, 3.5 μm) was used for separation and identification of chemical components in Danxiangguanxin injection with a mobile phase of 0.5 % acetic acid (A) and acetonitrile (B) in gradient elution. 0~25 min, 2%~33% B; 25~30 min, 33%~95% B; the flowing rate was 0.5 ml/min and the injection volume was 5 μl. And the time-of-flight mass spectrometer was equipped with an EIS ion source. Scanning mass range was ranged between m/z 100~1000. Results Thirty-one chemical compounds in Danxiangguanxin injection were identified unequivocally. Conclusion Chromatographic demonstration of chemical compounds in Danxiangguanxin injection could provide foundation for the further metabolism and action mechanism study of Danxiangguanxin injection.
2011, 29(3): 217-218.
Abstract:
Objective To isolate and identify the chemical constituents from the root of Solms-Laubachia lanata Botsch. Methods The compounds were isolated by column chromatography. The structures of the were compounds elucidated by spectroscopic analysis (NMR and MS). Results Four compounds were isolated and identified as β-sitosterol, Hexadecontanoic acid, daucosteol, 3α, 24-dihydroxyl-oleanane-12-ene-28-methyl ester. Hexadecontanoic acid, daucosteol, 3α, 24-dihydroxyl-oleanane-12-ene-28-methyl ester were isolated from Solms-Laubachia lanata Botsch for the first time.
Objective To isolate and identify the chemical constituents from the root of Solms-Laubachia lanata Botsch. Methods The compounds were isolated by column chromatography. The structures of the were compounds elucidated by spectroscopic analysis (NMR and MS). Results Four compounds were isolated and identified as β-sitosterol, Hexadecontanoic acid, daucosteol, 3α, 24-dihydroxyl-oleanane-12-ene-28-methyl ester. Hexadecontanoic acid, daucosteol, 3α, 24-dihydroxyl-oleanane-12-ene-28-methyl ester were isolated from Solms-Laubachia lanata Botsch for the first time.
2011, 29(3): 219-220.
Abstract:
Objective To investigate the utility and rationality of antibiotics in surgical patients with I class incision and regulate the method of preventive utility of antibiotics in surgery. Methods 166 patients with surgical operation during 2009 were retrospectively analyzed. Results All patients were given antibiotics. 107 patients were received antibiotics in two hours before the operation. Most patients were received one or two antibiotics during hospitalization. Conclusion Guidelines on the use of antibiotics in surgical patients were not sufficient. It is important for pharmacist to participate in clinical rational administration. It is essential to strengthen the supervision of antibiotics.
Objective To investigate the utility and rationality of antibiotics in surgical patients with I class incision and regulate the method of preventive utility of antibiotics in surgery. Methods 166 patients with surgical operation during 2009 were retrospectively analyzed. Results All patients were given antibiotics. 107 patients were received antibiotics in two hours before the operation. Most patients were received one or two antibiotics during hospitalization. Conclusion Guidelines on the use of antibiotics in surgical patients were not sufficient. It is important for pharmacist to participate in clinical rational administration. It is essential to strengthen the supervision of antibiotics.
2011, 29(3): 221-222,240.
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Objective To investigate and analyze the current package inserts of antimicrobial agents and provide references for the further standardization of drug package inserts. Methods A total of 185 package inserts of antimicrobial agents were collected and the marked items of drug use for pregnant and lactating women, paediatric patients, and geriatric patients were analyzed respectively. Results Among the package inserts, most marked items for drug use were found in pregnant and lactating women items, the proportion of which the marked items were still unknown was lower; it had higher proportion that marked items not yet established for drug use for all or part of age (month old, day old) paediatric patients in paediatric use items, and in some drug package inserts which were marked items lackage for drug use for paediatric patients in dosage and administration items, or marked not detailed and standard; moreover there was higher proportion of labeling as to dosage and administration in geriatric use items. Conclusion It was necessary to improve the drug package inserts continually so as to ensure the drug use safety.
Objective To investigate and analyze the current package inserts of antimicrobial agents and provide references for the further standardization of drug package inserts. Methods A total of 185 package inserts of antimicrobial agents were collected and the marked items of drug use for pregnant and lactating women, paediatric patients, and geriatric patients were analyzed respectively. Results Among the package inserts, most marked items for drug use were found in pregnant and lactating women items, the proportion of which the marked items were still unknown was lower; it had higher proportion that marked items not yet established for drug use for all or part of age (month old, day old) paediatric patients in paediatric use items, and in some drug package inserts which were marked items lackage for drug use for paediatric patients in dosage and administration items, or marked not detailed and standard; moreover there was higher proportion of labeling as to dosage and administration in geriatric use items. Conclusion It was necessary to improve the drug package inserts continually so as to ensure the drug use safety.
2011, 29(3): 223-225,237.
Abstract:
Objective To objective reflect and reveal current situation and work mode of the pharmacy department in third class A hospitals in shanghai. Methods Through the questionnaire survey and on-site interviews , data about staffing , content and quantity of operations were observed and collected to describe and compare by statistical methods . Results The work mode of pharmacy department was still the traditional support model-based drug supplying, about 60% of the staff of pharmacy were engaged in drug supplying . Less than 10% of the staff were engaged in clinical pharmacy. Pharmacy information technology and automation construction had been strengthened. Attention had been paid to pharmaceutical research. The research papers increased year by year. Conclusion The work mode of pharmacy department was in the blossom which was transforming from drug supplying to clinical pharmacy.
Objective To objective reflect and reveal current situation and work mode of the pharmacy department in third class A hospitals in shanghai. Methods Through the questionnaire survey and on-site interviews , data about staffing , content and quantity of operations were observed and collected to describe and compare by statistical methods . Results The work mode of pharmacy department was still the traditional support model-based drug supplying, about 60% of the staff of pharmacy were engaged in drug supplying . Less than 10% of the staff were engaged in clinical pharmacy. Pharmacy information technology and automation construction had been strengthened. Attention had been paid to pharmaceutical research. The research papers increased year by year. Conclusion The work mode of pharmacy department was in the blossom which was transforming from drug supplying to clinical pharmacy.
2011, 29(3): 226-228.
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Four kinds of medical security system models in forgien countries were compared and evaluated. The health insurance list entrance procedrue of new drugs in forgien countries was rapid, scientific, and convenient in evaluation and adminstration. Our country should learn from the successful experiences to strengthen the scientific support and coordination of the selection of Medicare directory , study the supporting policies and measures of the entrance of new drugs into the health insurance directory , and establish medical insurance catalog system for national conditions.
Four kinds of medical security system models in forgien countries were compared and evaluated. The health insurance list entrance procedrue of new drugs in forgien countries was rapid, scientific, and convenient in evaluation and adminstration. Our country should learn from the successful experiences to strengthen the scientific support and coordination of the selection of Medicare directory , study the supporting policies and measures of the entrance of new drugs into the health insurance directory , and establish medical insurance catalog system for national conditions.
2011, 29(3): 229-231.
Abstract:
Objective To analyze the rationality and status of drug utilization in military personnel outpatients by the index of rational drug use recommended by WHO. Methods 3000 prescriptions from Match to December in 2009 were randomly collected and analyzed by statistical methods. Results The average number of drugs per prescription was 3.2, the average drug expenditure per prescription was 113.3 yuan. There were 40% of those prescriptions which was over than 100 yuan. 5% of those prescriptions were injection drugs. The use rate of cardiovascular drugs was 35%, which were mainly calcium antagonists (18%) and ACEI (13%). Prescriptions of antibiotics were 33% which could be further standardized. All drugs were prescribed by generic name which were listed in Military Personnel Drug Directory for General Hospitals. 9% of prescription were irrational including prescriptions without proper indications, unreasonable dosage and administration, ect. conclusion The drug utilization in military personnel outpatients was basically rational. The utilization of antibiotics should be further standardized.
Objective To analyze the rationality and status of drug utilization in military personnel outpatients by the index of rational drug use recommended by WHO. Methods 3000 prescriptions from Match to December in 2009 were randomly collected and analyzed by statistical methods. Results The average number of drugs per prescription was 3.2, the average drug expenditure per prescription was 113.3 yuan. There were 40% of those prescriptions which was over than 100 yuan. 5% of those prescriptions were injection drugs. The use rate of cardiovascular drugs was 35%, which were mainly calcium antagonists (18%) and ACEI (13%). Prescriptions of antibiotics were 33% which could be further standardized. All drugs were prescribed by generic name which were listed in Military Personnel Drug Directory for General Hospitals. 9% of prescription were irrational including prescriptions without proper indications, unreasonable dosage and administration, ect. conclusion The drug utilization in military personnel outpatients was basically rational. The utilization of antibiotics should be further standardized.
2011, 29(3): 232-234.
Abstract:
Objective To discuss the application and the use experience of the Meta analysis in clinical pharmacy. Methods MEDLINE,ScienceDirect and other databases were searched. The literature and examples of Meta analysis application were summarized, synthesized, and analyzed. Results It was comfirmed that Meta analysis could be used well in the efficacy of the drug comparison,drug efficacy and adverse reactions re-evaluation,ultra drug direction usage provement, combination drug therapy and single drug therapy efficacy comparison,et al. Conclusion To judge the rationality of the drug use, clinical pharmacists should search the literature to find the answers. For the same problem, there had been many similar studies of the situation,clinical pharmacists could seach and read the literatures integrated with Meta analysis, then come to a full understanding of the problem.
Objective To discuss the application and the use experience of the Meta analysis in clinical pharmacy. Methods MEDLINE,ScienceDirect and other databases were searched. The literature and examples of Meta analysis application were summarized, synthesized, and analyzed. Results It was comfirmed that Meta analysis could be used well in the efficacy of the drug comparison,drug efficacy and adverse reactions re-evaluation,ultra drug direction usage provement, combination drug therapy and single drug therapy efficacy comparison,et al. Conclusion To judge the rationality of the drug use, clinical pharmacists should search the literature to find the answers. For the same problem, there had been many similar studies of the situation,clinical pharmacists could seach and read the literatures integrated with Meta analysis, then come to a full understanding of the problem.
2011, 29(3): 235-237.
Abstract:
Objective To discuss the methods to improve accounts and matter consentaneous rates in drug checking works under the hospital management information system. Methods The problems discovered in drug checking works were collected , the causes of bringing about accounts and matter unconsentaneous were analyzed, and the improvement measures were put forward. Results The prime causes of accounts and matter unconsentaneous were untimely entering accounts, accounting mistakes, drug dispensing mistakes, and imperfect system design. By standardizing drug dispensing processes and account operation requires, accounts and matter consentaneous rates reached above 96%. Conclusions The way of improving drug accounts and matter consentaneous rates was not check but management.
Objective To discuss the methods to improve accounts and matter consentaneous rates in drug checking works under the hospital management information system. Methods The problems discovered in drug checking works were collected , the causes of bringing about accounts and matter unconsentaneous were analyzed, and the improvement measures were put forward. Results The prime causes of accounts and matter unconsentaneous were untimely entering accounts, accounting mistakes, drug dispensing mistakes, and imperfect system design. By standardizing drug dispensing processes and account operation requires, accounts and matter consentaneous rates reached above 96%. Conclusions The way of improving drug accounts and matter consentaneous rates was not check but management.
2011, 29(3): 238-240.
Abstract:
Objective To investigate the current military online and centralized bidding medicine model and situation of local implementation of bidding essential drugs, and to explore the drug bidding model with military characteristics. Methods Literature review, field investigation and data analysis were used to analyze the advantages and disadvantages of the military and the local drug bidding models. Results There were certain problems existing in the operation of the online model of military centralized bidding medicines, and the local experiences could provide some references. Conclusion It was suggested that the General Logistics Department should organize the experts to establish a standardized evaluation system of medicine quality and promote the implement of related measures.
Objective To investigate the current military online and centralized bidding medicine model and situation of local implementation of bidding essential drugs, and to explore the drug bidding model with military characteristics. Methods Literature review, field investigation and data analysis were used to analyze the advantages and disadvantages of the military and the local drug bidding models. Results There were certain problems existing in the operation of the online model of military centralized bidding medicines, and the local experiences could provide some references. Conclusion It was suggested that the General Logistics Department should organize the experts to establish a standardized evaluation system of medicine quality and promote the implement of related measures.
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