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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(3): 188-192

LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.
Citation: LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.
shu

Experimental study on anti-myocardial ischemia effect of Yixintong

  • 1.

    208th Hospital of PLA, Changchun 130062,China

  • 2.

    School of Basic Medical Sciences,Jilin University,Changchun 130021,China

  • Received Date: 2010-01-20
  • Rev Recd Date: 2011-04-21
  • Objective To study the anti-myocardial ischemia effect of Yixintong. Methods The rat myocardial ischemia model was caused by isoprenaline and the experiment myocardial infraction dogs were used to observe the effect of Yixintong. Blood stasis model was used to observe the effect of Yixintong on blood viscosity and platelet aggregation. Results Yixintong (0.4 g/kg, 0.2 g/kg)could decrease ST length and rise serum enzyme(such as AST,CPK and LDH). Yixintong (0.4 g/kg,0.2 g/kg) could also lower the blood viscosity. Yixintong could improve hemorrheologic abnormality and lower the whole blood viscosity. Yixintong could inhibit platelet aggregation of rat. Yixintong could ameliorate the myocardial ischemia degree(Σ-ST) and decrease the myocardial ischemia coverage(N-ST). Yixintong could also decrease the rised serum enzyme(such as AST,CPK and LDH). Conclusions Yixintong had a protective and therapeutic action to the experimental myocardial ischemia.
  • [1] 陈 修. 心血管药物和药理学研究进展与展望[J]. 中国药理学与毒理学杂志,1995,9(3):161.
    [2] 张玉玺,姚晓颖,肖 艳,等.大根草提取物对模型大鼠心肌缺血的保护作用研究[J].中国药房,2009,20(33):2575.
    [3] 朴晋华,董培智,高天红,等.益心酮片对大鼠心肌缺血的保护作用[J]. 中国中药杂志,2003,28(5):442.
    [4] 张钧田.现代药理实验方法学[M].北京:北京医科大学中国协和医科大学联合出版社,1989:1153.
    [5] 邱 全 ,王 辉 ,王海洋 ,等.水蛭颗粒对大鼠急性血瘀模型血液流变学、SOD、MDA的影响[J].实用中医药杂志,2008,24(11):687.
    [6] 徐叔云,卞如濂,陈 修. 药理实验方法学[M].第2版.北京:人民卫生出版社,1991:854.
    [7] 李路江 ,吴子芳 ,吕文伟,等.红花提取物对犬急性心肌缺血的保护作用[J].中草药,2007,37(9):1381.
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Experimental study on anti-myocardial ischemia effect of Yixintong

  • 1. 208th Hospital of PLA, Changchun 130062,China
  • 2. School of Basic Medical Sciences,Jilin University,Changchun 130021,China
  • Received Date: 2010-01-20
  • Rev Recd Date: 2011-04-21

Abstract: Objective To study the anti-myocardial ischemia effect of Yixintong. Methods The rat myocardial ischemia model was caused by isoprenaline and the experiment myocardial infraction dogs were used to observe the effect of Yixintong. Blood stasis model was used to observe the effect of Yixintong on blood viscosity and platelet aggregation. Results Yixintong (0.4 g/kg, 0.2 g/kg)could decrease ST length and rise serum enzyme(such as AST,CPK and LDH). Yixintong (0.4 g/kg,0.2 g/kg) could also lower the blood viscosity. Yixintong could improve hemorrheologic abnormality and lower the whole blood viscosity. Yixintong could inhibit platelet aggregation of rat. Yixintong could ameliorate the myocardial ischemia degree(Σ-ST) and decrease the myocardial ischemia coverage(N-ST). Yixintong could also decrease the rised serum enzyme(such as AST,CPK and LDH). Conclusions Yixintong had a protective and therapeutic action to the experimental myocardial ischemia.

LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.
Citation: LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.
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