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2011 Vol. 29, No. 2

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Role of the NALP3 inflammasome in Alzheimer's disease
ZHAO Ting, SHEN Fu-ming
2011, 29(2): 81-82,88.
Abstract(3161)
Abstract:
The NALP3 inflammasome , a novel discovered plasmosin , is in-volved in immune inflammatory response . Recent studies indicated that the NALP3 inflammasome had close association with Alzheimer's disease . In this paper , the association of the NALP3 ...
Progress on Danshensu derivatives
WANG Ting-fang, ZHENG Li-ping, ZHANG Ning, JIN Lei, WU Qiu-ye, ZHANG Chuan
2011, 29(2): 83-88.
Abstract(3702)
Abstract:
Danshensu is the major water-soluble phenolic acids of Danshen. It possessed diverse pharmacological effects, especially the protective effects on cardiovascular diseases. Due to its significant pharmacological activities, synthesis of danshensu deri...
Research on type 2 sodium glucose co-transporters in diabetes treatment
DING Hai-feng, CAO Yong-bing, AN Mao-mao, JIA Xin-ming, JIANG Yuan-ying
2011, 29(2): 89-92,116.
Abstract(3340)
Abstract:
In the last few years, inhibitors of the type 2 sodium glucose co-transporters (SGLT2) had been the subject of novel approach to treating diabetes. SGLT2 played a major role in physiology of glucose reabsorption from proximal part of kidney. The bloc...
Application of micro-dialysis-LC/MS in pharmaceutical analysis
LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng
2011, 29(2): 93-96,119.
Abstract(3803)
Abstract:
Objective To review the micro-dialysis coupled with chromatographic technologies in pharmaceutical analysis in vivo. Methods The relevant literatures were collected to make a summary of microdialysis coupled with chromatography technology in pharmace...
Cloning,expression,purification and subcellular localization of human ribosomal protein S3a
LIU Ying, LI Jian-zhong, ZHANG Jun-ping
2011, 29(2): 97-100.
Abstract(3302)
Abstract:
Objective To express and purify the human ribosomal protein S3a and study the subcellular localization of human ribosomal protein S3a. Methods The RPS3a gene was obtained by RT-PCR, total RNA extracted from human HEK293 cell as the template,and clone...
Study of preparation and release rate of felodipine sustained release tablet
ZHU Yu-qiu, GUO Shen-rong
2011, 29(2): 101-104,108.
Abstract(3317)
Abstract:
Objective To prepare felodipine sustained release tablet and evaluate the similitude of release rate with original preparation. Methods Matrix technology was used. felodipine sustained release tablet was prepared through studying the influence of mat...
Optimization of decolorization technology of the Oxytropis falcata total flavones with active carbon by orthogonal experiment
DU Qing-yun, HONG Jia-ni, LI Mao-xing, CHEN Jin-shan
2011, 29(2): 105-108.
Abstract(2620)
Abstract:
Objective To optimize the decolorization technology of Oxytropis falcata total flavones with active carbon. Methonds Temperature, stirring time and the content of active carbon were used as the orthogonal experiment factors. The colour of filtrate, t...
Determination of sodium Danshensu in rat plasma by HPLC-MS/MS
WANG Jing, JIN Lei, XIONG Li-yan, WANG Ting-fang, ZHENG Li-ping, ZHANG Ning, ZOU Hao, ZHANG Chuan
2011, 29(2): 109-110,130.
Abstract(3053)
Abstract:
Objective To estiblish a method of determining sodium Danshensu in rat plasma by HPLC-MS/MS. Methods sodium Danshensu was extrated for determination by HPLC-MS/MS. Analytical column was Diamonsil C18 (4.6 mm×200 mm ,5 μm). The mobile phase was methan...
Effects of pravastatin on nitric oxide production in endothelial progenitor cells
XIAO Gang-feng, ZHANG Huai-qin
2011, 29(2): 111-113.
Abstract(2663)
Abstract:
Objective To investigate the effects of pravastatin on nitric oxide production in endothelial progenitor cells. Methods Total mononuclear cells(MNCs) were isolated from peripheral blood by Ficoll density gradient centrifugation,and cultured in vitro....
Optimization of the synthesis of photosensitizer purpurin-18 by orthogonal design
WANG Yao, YAO Jian-zhong, MIAO Zhen-yuan, SHENG Chun-quan, ZHANG Wan-nian
2011, 29(2): 114-116.
Abstract(3600)
Abstract:
Objective To optimize the synthesis of photosensitizer purpurin-18(1). Methods Target compound 1 was synthesized through air oxidation and simultaneously ring cleavage of pheophorbide a (2) in presence of alkali. Four main factors influencing synthet...
Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection
LIU Xiu-fang, LIU Shao-ming, WU Tian-tian
2011, 29(2): 117-119.
Abstract(2608)
Abstract:
Objective To evaluate the efficacy and safety of cimetidine on Mycoplasma pneumoniae infection. Methonds 80 MPI patients were selected and randomized into the observation group and the control group averagely. The two groups were treated with azithro...
Research on bacterial endotoxin test for compound sodium lactate injection No.3
FU Cong, GAO Jin, JI Yang, NIE Yu-qiong, CHENG Yang, FU Xiao-fei
2011, 29(2): 120-121,148.
Abstract(3090)
Abstract:
Objective To establish the method of bacterial endotoxin test for compound sodium lactate injection No.3. Methods The method based on the bacterial endotoxin test in Chinese pharmacopoeia 2005 edition was used. Results Neither inhibition nor enhancem...
Detection of donepezil from serum by on-line sample preparation RAM-HPLC
MA Jun, FAN Peng-cheng, REN Jun, JIA Zheng-ping
2011, 29(2): 122-124.
Abstract(2641)
Abstract:
Objective To establish a sample preparation restricted access material (RAM) HPLC method for the quantification of donepezil in human serum. Method The sample was prepocessed by LiChrospher ADS C18 (25 mm × 4 mm,25 μm) as pre-column and analyzed by ...
Investigation on stability of procaine hydrochloride injection
YOU Ben-ming, SONG Hong-jie
2011, 29(2): 125-127.
Abstract(3658)
Abstract:
Objective To investigate the effect of temperature and humidity on the stability of procaine hydrochloride injection. Methods Three batches of the test samples were stored in condition of 40±2 centigrade, relative humidity 75%±5% for 0 month,2 months...
Establishment of bacterial endotoxins test in extracts injection from rabbit skin inflamed by vaccinia virus
WANG Zong-chun, ZHOU Yan-an, ZHANG Hong
2011, 29(2): 128-130.
Abstract(2959)
Abstract:
Objective To establish a method for the detection of bacterial endotoxin in extracts injection from rabbit skin inflamed by vaccinia virus. Methods The interference test was carried out according to the guideline and procedure specified in appendix Ⅺ...
Data mining the association rules in outpatient service prescriptions
FU Xiang, YANG Zhang-wei, CHEN Sheng-xin, CHEN Chang-hong, HE Yu-tao, HUANG Xiao-zhong
2011, 29(2): 131-134,160.
Abstract(2603)
Abstract:
Objective To mine the association rules in and to identify the patterns of the prescription. Methods PASW Modeler 13 was applied to establish Apriori model and analyze the data. Results In 47 132 prescriptions, the drugs for prophylaxis and treatment...
Reflection on demand characteristics and selection of medicinal species in emergency pharmaceutical supply
CHEN Jing, GU Wen-hua, CHEN Sheng-xin, SHU Li-xin
2011, 29(2): 135-137.
Abstract(3277)
Abstract:
Objective To investigate the system of emergency medical supply and enhance the efficiency of drug supply in emergency. Methods Characteristics of emergency medicine were analyzed, the scope, principles and problems of medicine selection were determi...
Strengthening of administration in drug validity duration
WANG Wen-sen, SUN Jie, LIU Shun-liang, YIN Xiao-fei
2011, 29(2): 138-138,155.
Abstract(2675)
Abstract:
The important factors which ensuring safe drug use of patients was to use drug beyond their expiry date. A method of changing expired drugs back for free which was built up to strengthen the administration in drug validity duration, improvement the s...
Application of antibacterial drugs of 161 patients in perioperative period
CHEN Shu-min, TIAN Wen-yuan, JIANG Hong
2011, 29(2): 139-141,145.
Abstract(2393)
Abstract:
Objective To investigate the utilization of perioperative antibacterial agents in Fuxing Hospital,and provide references for rational use of drugs in clinic. Methods 161 cases of patients were sampled randomly from the operation cases from June to De...
Five-year monitoring of clinical rational drug use in our hospital
SUN Di-qing, LIU Wei, SONG Shu-wei
2011, 29(2): 142-145.
Abstract(2962)
Abstract:
Objective To evaluate the status of drug use of the inpatients, summarize the problems of PASS and raise the related suggestion. Methods PASS-nested "Army Health No.1" hospital information system was used to evaluated the drug utilization in these pa...
Analysis and prevention of medication error in outpatient pharmacy
YANG Chang-yun, PANG Su-qiu, FENG Shao-qing
2011, 29(2): 146-148.
Abstract(2765)
Abstract:
Objective To analysis the medication errors and provide prevention methods. Methods The reason of concrete medication error examples in our hospital were analyzed. The policies to prevent medication errors were put forward. Results and conclusion The...
Study on 100 cases of adverse reactions of aripipirazole tablets
TANG Yuan, LI Zhi-quan, LIU Man-ying
2011, 29(2): 149-151.
Abstract(3003)
Abstract:
Objective To analyze the characteristics of adverse drug reactions (ADR) induced by aripipirazole tablets. Methods The reports of ADRs published during 2002~2008 induced by aripipirazole tablets were studied. Results Primary symptoms of ADRs induced ...
2011, 29(2): 152-152.
Abstract(2591)
Abstract:
Emphasis on teaching and learning Latin names in medicinal botany and pharmacognosy curriculum
ZHANG Lei, XIN Hai-liang, HAN Ting, QIN Lu-ping, ZHANG Hong
2011, 29(2): 153-155.
Abstract(3016)
Abstract:
Species binomial arranged by natural systems to ensure uniform standards of humanity can give a common understanding of life on Earth. Latin name of medicinal plants and crude drugs is an important component of botany and pharmacognosy theory teachin...
Practice and reformation of experimental teaching combination of analytical chemistry and pharmaceutical analysis
SHANG Xiao-jun, YANG Li-juan, MA Su-ying, SUN Xiang-de
2011, 29(2): 156-157.
Abstract(2666)
Abstract:
Analytical chemistry and pharmaceutical analysis are two major courses of pharmacy.Based on the relations of them, the experimental teaching reform of combining the two courses had been done, to the aims of improving teaching effect , cultivating the...
Probe and reformation of pharmaceutical equipment and process design workshop
WAN Chun-jie, WANG Cun-wen, ZHANG Heng, YANG Yi-hong
2011, 29(2): 158-160.
Abstract(2716)
Abstract:
In order to strengthen the students' engineering ability, the advanced , scientific contents and various teaching approaches should be adopted in the teaching of pharmaceutical equipment and process design workshop curricula through the scientific an...