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Volume 29 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(2): 101-104,108

ZHU Yu-qiu, GUO Shen-rong. Study of preparation and release rate of felodipine sustained release tablet[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 101-104,108.
Citation: ZHU Yu-qiu, GUO Shen-rong. Study of preparation and release rate of felodipine sustained release tablet[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 101-104,108.
shu

Study of preparation and release rate of felodipine sustained release tablet

  • 1.

    School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240,China;Shanghai Ethypharm Pharmaceutical Company Ltd., Shanghai 201702,China

  • 2.

    School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240,China

  • Received Date: 2010-04-28
  • Rev Recd Date: 2010-09-19
  • Objective To prepare felodipine sustained release tablet and evaluate the similitude of release rate with original preparation. Methods Matrix technology was used. felodipine sustained release tablet was prepared through studying the influence of matrix material sorts, viscosity, quantity, fillers and process. The similitude of release rateof SR tablet were evaluated in 4 kinds of pH media with original preparation. Results The release rate of felodipine sustained release tablet which was prepared by HPMC as matrix material ,applied by wet granulation with alcohol content of 80% and granulation time of 40 sec, was similar to original preparation with the hardness between 50~70 N. F2 functions of release rate in 4 kinds of pH media were all exceed 50. Conclusions Release rate of felodipine sustained release tablet prepared was similar to original preparation.
  • [1] 陈新谦,金有豫,汤 光. 新编药物学[M]. 第15版. 北京:人民卫生出版社,2003. 324~383.
    [2] 杜丽娜. 非洛地平[J]. 临床药物治疗杂志,2004,2(1):46.
    [3] 李红梅. 非洛地平缓释片治疗原发性高血压效果指数研究[J]. 中国实用神经疾病杂志,2009,12(14):55.
    [4] 梁 竹,魏继鲁,张 华. 非洛地平缓释片释放度比较[J]. 中国现代应用药学杂志,2006,23(1):41.
    [5] 梁 竹,王宝德,于燕莉,等. 不同产品非洛地平缓释片药物动力学比较[J]. 中国临床药理学与治疗学,2005,10(5):551.
    [6] 仿制药生物等效性试验指导[Z]. 日本药品医疗安全局.2002:273.
    [7] 颜耀东. 缓释控释制剂的设计与开发[M]. 北京:中国医药科技出版社,2006. 73.
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Study of preparation and release rate of felodipine sustained release tablet

  • 1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240,China;Shanghai Ethypharm Pharmaceutical Company Ltd., Shanghai 201702,China
  • 2. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240,China
  • Received Date: 2010-04-28
  • Rev Recd Date: 2010-09-19

Abstract: Objective To prepare felodipine sustained release tablet and evaluate the similitude of release rate with original preparation. Methods Matrix technology was used. felodipine sustained release tablet was prepared through studying the influence of matrix material sorts, viscosity, quantity, fillers and process. The similitude of release rateof SR tablet were evaluated in 4 kinds of pH media with original preparation. Results The release rate of felodipine sustained release tablet which was prepared by HPMC as matrix material ,applied by wet granulation with alcohol content of 80% and granulation time of 40 sec, was similar to original preparation with the hardness between 50~70 N. F2 functions of release rate in 4 kinds of pH media were all exceed 50. Conclusions Release rate of felodipine sustained release tablet prepared was similar to original preparation.

ZHU Yu-qiu, GUO Shen-rong. Study of preparation and release rate of felodipine sustained release tablet[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 101-104,108.
Citation: ZHU Yu-qiu, GUO Shen-rong. Study of preparation and release rate of felodipine sustained release tablet[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 101-104,108.
shu

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