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LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.
Citation:
LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.
Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection
Objective To evaluate the efficacy and safety of cimetidine on Mycoplasma pneumoniae infection. Methonds 80 MPI patients were selected and randomized into the observation group and the control group averagely. The two groups were treated with azithromycin, while the observation group was given cimetidine additionally. Peripheral blood eosinophils (EOS) and total IgE (T-IgE) were detected before and after the treatment which were used to evaluated the effects of cimetidine. Results The cure rate of observation group was 60.00%s and significantly higher than that of the control group which was 37.50% There was statistically significant of the cure rate (P<0.05, see Table 1) between two groups. The EOS level of the observation group decreased significantly after a course of treatment (P<0.001, see Table 2), the EOS level of the control group also decreased but had no significant difference (P>0.05) with the level before treatment. T-IgE level of two groups nearly had no change. The observation group occurred 1case of rash and 1 case of gastrointestinal reaction. The control group occurred 3 cases of gastrointestinal reactions and 2 cases of rash. The adverse reaction rate of two groups had no significant difference (P>0.05). Conclusion Cimetidine for adjuvant treatment of MPI with azithromycin is efficiency and safety which should be recommended in clinic.
Yanagihara K, Izumikawa K, Higa F,et al. Efficacy of azithromycin in the treatment of community-acquired pneumonia, including patients with macrolide-resistant Streptococcus pneumoniae infection[J]. Intern Med,2009,48(7):527.
[6]
Morozum IM,Hasegawa K,Chiba N,et al.Application of PCR for Mycoplasm a pneumoniae detection in children with communitvacquired pneumonia[J].Infect Chem other,2004,10(5):274.
Abstract: Objective To evaluate the efficacy and safety of cimetidine on Mycoplasma pneumoniae infection. Methonds 80 MPI patients were selected and randomized into the observation group and the control group averagely. The two groups were treated with azithromycin, while the observation group was given cimetidine additionally. Peripheral blood eosinophils (EOS) and total IgE (T-IgE) were detected before and after the treatment which were used to evaluated the effects of cimetidine. Results The cure rate of observation group was 60.00%s and significantly higher than that of the control group which was 37.50% There was statistically significant of the cure rate (P<0.05, see Table 1) between two groups. The EOS level of the observation group decreased significantly after a course of treatment (P<0.001, see Table 2), the EOS level of the control group also decreased but had no significant difference (P>0.05) with the level before treatment. T-IgE level of two groups nearly had no change. The observation group occurred 1case of rash and 1 case of gastrointestinal reaction. The control group occurred 3 cases of gastrointestinal reactions and 2 cases of rash. The adverse reaction rate of two groups had no significant difference (P>0.05). Conclusion Cimetidine for adjuvant treatment of MPI with azithromycin is efficiency and safety which should be recommended in clinic.
LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.
Citation:
LIU Xiu-fang, LIU Shao-ming, WU Tian-tian. Evaluation of the therapeutic effect of cimetidine on Mycoplasma pneumoniae infection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 117-119.
Yanagihara K, Izumikawa K, Higa F,et al. Efficacy of azithromycin in the treatment of community-acquired pneumonia, including patients with macrolide-resistant Streptococcus pneumoniae infection[J]. Intern Med,2009,48(7):527.
[6]
Morozum IM,Hasegawa K,Chiba N,et al.Application of PCR for Mycoplasm a pneumoniae detection in children with communitvacquired pneumonia[J].Infect Chem other,2004,10(5):274.
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