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Volume 29 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(2): 149-151

TANG Yuan, LI Zhi-quan, LIU Man-ying. Study on 100 cases of adverse reactions of aripipirazole tablets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 149-151.
Citation: TANG Yuan, LI Zhi-quan, LIU Man-ying. Study on 100 cases of adverse reactions of aripipirazole tablets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 149-151.
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Study on 100 cases of adverse reactions of aripipirazole tablets

  • The 422rd Hospital of PLA,Zhanjiang 524009, China

  • Received Date: 2010-06-10
  • Rev Recd Date: 2010-12-06
  • Objective To analyze the characteristics of adverse drug reactions (ADR) induced by aripipirazole tablets. Methods The reports of ADRs published during 2002~2008 induced by aripipirazole tablets were studied. Results Primary symptoms of ADRs induced by aripipirazole tablets were headache, sleeplessness, anxious, sick,vomiting, hypersomnia, intense and cathisophobia, which were usually occurred in 1~2 weeks. conclusion ADRs induced by aripipirazole tablets have multiple factors which should be highly concerned in clinical use.
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    [2] Inoue A,Nakata Y.Strategy for modulation of central dopamine transmission based on the partial agonist concept in schizophrenia therapy[J].Jpn J Pharmacol,2001,86:376.
    [3] Lieberman JA.Dopamine partial agonists:a new class of antipsychotic[J].CNS Drugs,2004,18(4):251.
    [4] Marder SR,McQuade RD,Stock E. Aripipirazole in the treatment of schizophrenia:safety and tolerability in the treatment of schizophrenia: safety and tolerability in the short-term,placebocontrolled trials[J].Schizophr Res,2003,1916:1.
    [5] Logue DD,Gonzalez N,Heligman SD,et al.Hyperglycemia in a 7-year-old child treeyed with Aripipirazole[J].Am J Psychiatry,2007,164(1):173.
    [6] Newcomer JW,Haupt DW. The metabolic effects of antipsychotic medications[J].Can J Psychiatry,2006,51:480.
    [7] McQuade RD,Stock E,Marcus R, et al. A comparison of weight change during treatment with olanzapine or aripipirazole:results from a randomized,double-blind study[J].J Clin Psychiatry,2004,65(Suppl 18):47.
    [8] ADA.Consensus development conference on antipsychotic drugs and obesity and diabetes (American Diabetes Association; American Psychiatric Association; American Association of clinical Endocrinologists;North American Association for the study of obesity)[J].Diabetes Care,2004,27:596.
    [9] De Hert M,Hanssens L,Winkel R, et al. A case series:evaluation of the metabolic safety of aripipirazole[J]. Schizophr,2007,33:823.
    [10] Olfson M,Marcus SC,Corey-Lisle P,Hyperlipidemia forlowing treatment with antipsychotic medications[J].Am J Psychiatry,2006,163:1821.
    [11] Lee BH,Kim YK,Park SH.Using aripipirazole to resolve antipsychotic-induced symptomatic hyperprolactinemia: A pilot study Prog Neuropsychopharmacol Biol Psychiatry[J]. 2006,30:714.
    [12] Anghelescu I,Wolf J.Successful switch to aripipirazole after induction of hyperprolactinemia by ziprasidone:a case report[J].J Clin Psychiatry,2004,65:1286.
    [13] Hanssens L,L Italien G,Marcus R, et al. Sexual dysfunction in naturalistic,open-label study of aripipirazole and standard-of-care in community-treated patients with schizophrenia(the STAR trial)[C].Toronto,Canada: American Psychiatric Association 159th annual meeting.2006.
    [14] Abilify Summary of Product Characteristics[C].London:Otsuka Pharmaceutical Europe Ltd;2006.
    [15] Oosterhuis M, Van De Kraats G,Tenback D.Safety of Aripipirazole:high serum levels in a CYP2D6 mutated patient[J].Am J Psychiatry,2007,164(1):175.
    [16] Spina E,de Leon J. Metabolic drug interactions with newer antipsychotics: a comparative review[J].Basic Clin Pharmacol Toxicol,2007,100(1):4.
    [17] Kan JM, Carson WH, Saha AR, et al. Efficacy and safety of aripipirazole and haloperidol versus placebo in patients with schizophrenia and schizophrenia disorder[J]. JClin Psychiatry,2002,63:763.
    [18] Keck PE, Jr, McElroy SL. Aripipirazole: a partial dopamine D2 receptor agonist antipsychotic[J].Expert Opin Investig Drugs,2003,12:655.
    [19] De Hert M,Hanssens L,van Winkel R, et al.Reversibility of antipschotic treament-related diabetes in patients with schizophrenia:a case of switching to aripipirazole[J]. Diabetes Care,2006,29:2329.
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Study on 100 cases of adverse reactions of aripipirazole tablets

  • The 422rd Hospital of PLA,Zhanjiang 524009, China
  • Received Date: 2010-06-10
  • Rev Recd Date: 2010-12-06

Abstract: Objective To analyze the characteristics of adverse drug reactions (ADR) induced by aripipirazole tablets. Methods The reports of ADRs published during 2002~2008 induced by aripipirazole tablets were studied. Results Primary symptoms of ADRs induced by aripipirazole tablets were headache, sleeplessness, anxious, sick,vomiting, hypersomnia, intense and cathisophobia, which were usually occurred in 1~2 weeks. conclusion ADRs induced by aripipirazole tablets have multiple factors which should be highly concerned in clinical use.

TANG Yuan, LI Zhi-quan, LIU Man-ying. Study on 100 cases of adverse reactions of aripipirazole tablets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 149-151.
Citation: TANG Yuan, LI Zhi-quan, LIU Man-ying. Study on 100 cases of adverse reactions of aripipirazole tablets[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 149-151.
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