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2011 Vol. 29, No. 1

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The key function of IRAK-4 in the inflammation signal pathway mediated by Toll-like receptors
LI Fan, RUI Yao-Cheng
2011, 29(1): 1-3,14.
Abstract(3407)
Abstract:
interleukin-1 receptor-associated kinase 4 (IRAK-4) is a key molecular which participates in the innate immune processes. It belongs to the IRAK family with the other three members: IRAK-1, IRAK-2, and IRAK-M. However, It has been found that IRAK-4 p...
Progress of chemical constituents and pharmacological research of Dendropanax
ZHENG Li-Ping, WANG Ting-Fang, XIONG Li-Yan, ZOU Hao, ZHANG chuan
2011, 29(1): 4-7,67.
Abstract(2955)
Abstract:
Objective To presente a view of chemical and pharmacological study on Dendropanax and lay a solid foundation for further research. Methods Relevant literature of Dendropanax were searched and summarized. Results and Conclusion The main chemical const...
Research progress of chitosan derivatives as gene delivery vector
LI Yan
2011, 29(1): 8-10,61.
Abstract(2641)
Abstract:
Despite the advantages of chitosan as a non-viral gene delivery vector, the application of this system is significantly limited by its poor solubility (the amino groups on chitosan are only partially protonated at physiological pH 7.4), poor stabilit...
The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase
LV Xiao-Qun, ZHANG Ruo-Yu, MIAO Chao-Yu
2011, 29(1): 11-14.
Abstract(3118)
Abstract:
nicotinamide phosphoribosyl transferase (Nampt) is an essential protein with a variety of physiological functions and performs potential functions on many diseases such as cardiovascular diseases, diabetes, cancer and autoimmune diseases. It is of gr...
Determination of Atorvastatin in human plasma by LC-MS-MS
Jiang Nan, Yang Yong-Ge, Xu Xue-Ting, Zhao Gang-Tao
2011, 29(1): 15-16,70.
Abstract(3443)
Abstract:
Objective To establish a method for determining Atorvastatin in human plasma by LC-MS-MS. Methods Atorvastatin was extracted for determination by LC-MS-MS. Analytical column was Thermo BioBasic-C8(2.1 mm×100 mm,5 μm). The mobile phase was acetonitril...
Synthesis of 4'-alkoxy-1,1'-bisphenyl-4-carboxylic acid lipotripeptides
ZHOU Ting, YAO Jian-Zhong, ZHANG Dong-Wei, LIU Hong-Ming, SHENG Chun-Quan, MIAO Zhen-Yuan, ZHANG Wan-Nian
2011, 29(1): 17-20.
Abstract(2706)
Abstract:
Objective To prepare 4'-alkoxy-1,1'-bisphenyl-4-carboxylic acid lipotripeptides , which is the key intermediates for total synthesis of novel caspofungin-like cyclohexalipopeptide antifungal agents. Methods Starting from Pro-O-t-Bu , the target compo...
Bio-efficacy of seven skin-lighteners on dermal melanocytes in vitro
ZHANG Wei, GAO Jing, ZHANG Min, WANG Xiao-Yu, HOU Xue-Mei, GAO Shen
2011, 29(1): 24-26,40.
Abstract(3297)
Abstract:
Objective To investigate the bio-efficacy of seven skin-lighteners on melanocytes in vitro. Methods After B-16 melanoma cells were treated with skin-lightener, the tyrosinase activity, the melanin content and cell viability were measured by utilizati...
Study on synthesis of Fmoc-L-Asp-4-OBn
WANG Liang, NI Lan, ZHANG Chun-Mei, GUO Jun-Xiang, HU Hong-Gang, WU Qiu-Ye
2011, 29(1): 27-28.
Abstract(3092)
Abstract:
Objective To design and synthetize new derivatives of aspartic acid from L-Asp-1-OtBu and to study the importance of new derivatives in the synthesis of cyclic peptide. Methods Starting from L-Asp-1-OtBu, the benzyl was introduced on the four positio...
Environmentally synthesis of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one
GUO Yao, CHEN Ying, YU Zong-Min, YUAN Wen-Lin, WANG Xiao-Yan, HE Bang-Ping, SUN Qing-Yan
2011, 29(1): 29-30,77.
Abstract(2521)
Abstract:
Objective To explore an easily-controled, environmentally benign synthetic method of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one. Methods 4-phenyl-5-ethoxy-carbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one was synthesized from ...
Determination of residual by headspace gas chromatography organic solvents in piroxicam
LI Yu, ZHAO Jing-xia, YANG Gen-jin, DONG Xin, LI Ling, SU Li, ZHANG Wei
2011, 29(1): 31-32.
Abstract(2915)
Abstract:
Objective To establish a headspace capillary gas chromatgraphy for determination the residual organic solvents in piroxicam. Methods The residual solvents in piroxicam which are methanol , ethanol, toluene and dimethybenzene were determined by headsp...
Determination of a flavonol glycoside in Equisetum hiemale by RP-HPLC
LI Yan, ZHU Jin-Hui, LI Dan, GUO Cheng
2011, 29(1): 33-34,37.
Abstract(2942)
Abstract:
Objective To establish a RP-HPLC method for determination of a flavonol glycoside in Equisetum hiemale. Methods The separation was performed on Calesil ODS-100(250 mm×4.6 mm,5 μm). Mobile phase consisted of methanol-water (45:55) with flow rate of 1....
Fast detection of hypoglycemic drugs by portable Raman spectrometer
LUO Ya, LIU Yan, HU Xi-xi, LU Feng
2011, 29(1): 35-37.
Abstract(3458)
Abstract:
Objective To investigate the identification capability of portable Raman spectrometer for hypoglycemic drugs. Methods The Raman spectra of the standard substance of active pharmaceutical ingredient of the hypoglycemic drugs and their corresponding pr...
Determination of Tanshinone IIA by Fluorescence Spectrophotometry
LIN Mei-yu, FU Wei, GONG Xiao-bin, LIN Jin-ming, WANG Xiao-yan
2011, 29(1): 38-40.
Abstract(3108)
Abstract:
Objective To study the fluorescence properties and analysis method of Tanshinone IIA. Methods Influencial factors including acidic media, the concentrations of substrate on the fluorescence intensity were studied. The stability of fluorescence of Tan...
Dronedarone a new drug for atrial fibrillation or atrial flutter
LV Juan-li, LIU Yang, Li Yan, Liu Zhen-hua
2011, 29(1): 41-44.
Abstract(2726)
Abstract:
Dronedarone is analogues as amiodarone, the structure is not iodine, reducing iodine-induced organ toxicity, is one of the new anti-arrhythmia drugs. on July 1, 2009 , It has been approved by FDA for the treatment of atrial fibrillation or atrial flu...
Design and preliminary construction of multidimensional data system for drug utilization
FU Xiang, YANG Zhang-wei, CHEN Sheng-xin, CHEN Chang-hong, HE Yu-tao, HUANG Xiao-zhong
2011, 29(1): 45-47,57.
Abstract(2420)
Abstract:
Objective To advance the data analysis of hospital drug utilization. Methods The analysis system is designed for the subject of "drug utilization", which was based on HIS, the theory of multimentional cube and OLAP. "Drug", "patient", "institution" a...
Research on method of providing services for basic level troops by clinical pharmacists
WANG Wen-Sen, LIU Shun-Liang, SUN Jie, YU Xue-Zhong
2011, 29(1): 48-49.
Abstract(2596)
Abstract:
The fundamental aim of Military Hospital is to provide services to basic level troops. It was the key research point of military hospital to study how to express the advantage of talented personnel and technology to improve the services level to basi...
Development and application of System Software of Total Parenteral Nutrition Prescription Inspection in Our Hospital
LUAN Xiao-Lin, ZHU Jia-Jie, CAO Jin-Hua, HUANG Yu-Feng
2011, 29(1): 50-51.
Abstract(3096)
Abstract:
Objective To improve the effectiveness and efficiency of the total parenteral nutrition (TPN) prescriptions inspection. Method Based on the original hospital information system, Powerbuilder 6.5 system front database development tool was used and the...
Selection of National Pharmaceutical Stockpile Decision-making Models
SHU li-xin, CHEN Sheng-xin
2011, 29(1): 52-54.
Abstract(2718)
Abstract:
objective To review decision-making models for national pharmaceutical stockpile. Methods using the method of literature investigation, logical analysis to compared storage models according to the characteristics of drugs. Results demand of national ...
Discussion on Medical Supply Model in Military Operations other than War
Chen Jing, Shu Li-Xin, Gu Wen-Hua, Chen Sheng-Xin
2011, 29(1): 55-57.
Abstract(3254)
Abstract:
According to characteristics of military operations other than war,and the analysis of medical supply, some key points and difficult points in medical supply were found,such as the unbalance of demands and supplies of out of time in supplies. The lim...
Discussion on developing trends of civilian medical material mobilization in our country
DING Qing-Xue, FU Xiang, CHU Wen-Gong, CHEN Sheng-Xin
2011, 29(1): 58-61.
Abstract(2380)
Abstract:
Combined with the situation of our country and military, according to the research basis of defense mobilization and defense health mobilization, the civillian medical material mobilization, which was still a special blank research field was analyzed...
The problems and countermeasures of drug utility in troops below division level at ordinary times
CHEN Lin, LIU Zhao-Yuan, MAO Chang-Xue, ZHANG Jiong
2011, 29(1): 62-64.
Abstract(2496)
Abstract:
Objective To grasp the status and analyze the problems of drug utility in troops below division level at ordinary times. To put forward the suggestion and countermeasures to promote the rational drug utility in troops below division level at ordinary...
Chemical emergency medicine security study outlined Protection of medicinal chemistry Emergency Overvie
FU Yan-Yan, WANG Yuan-Yuan, CHU Wen-Gong
2011, 29(1): 65-67.
Abstract(2781)
Abstract:
Objective To analyze the medicine guarantee status for the chemical emergencies and supply the relevant suggestions. Methods Literature analysis was used to study the development of chemical emergency medicine, and the coping strategies were proposed...
Problems and countermeasures of emergency medical material support in military operation other than war
WANG Yuan-Yuan, FU Yan-Yan, CHEN Shen-Xin
2011, 29(1): 68-70.
Abstract(2827)
Abstract:
Objective To explore the problems and put forward the countermeasures of emergency medical material support in MOOTW. Methods According to the basic characteristics of emergency medical material support in MOOTW , the shortage of collection, reservat...
Exploration of the Cultivating Model of Clinical Pharmaceutical Postgraduates
Song Hong-Tao, Deng Jie, Zhang Qian
2011, 29(1): 71-74.
Abstract(2652)
Abstract:
By analyzing the current situation and shortcomings of clinical pharmaceutical postgraduates' education model, the appropriate cultivating model which to satisfy the need of clinical pharmaceutical work were explored, combining the development of cli...
The significance and necessity of establishing the campus plant website
WANG Xu-Hong
2011, 29(1): 75-77.
Abstract(2294)
Abstract:
On the basis of plant exists in campus and campus internet currently, the significance and necessity of establishing the campus plant website were illustrated, in accordance with teaching characteristics of the pharmaceutical botany. The contents wou...