GUO Yao, CHEN Ying, YU Zong-Min, YUAN Wen-Lin, WANG Xiao-Yan, HE Bang-Ping, SUN Qing-Yan. Environmentally synthesis of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 29-30,77.
| Citation:
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GUO Yao, CHEN Ying, YU Zong-Min, YUAN Wen-Lin, WANG Xiao-Yan, HE Bang-Ping, SUN Qing-Yan. Environmentally synthesis of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 29-30,77.
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Environmentally synthesis of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one
- 1.
14th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China
- 2.
13th Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China
- 3.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2010-05-25
- Rev Recd Date:
2010-06-10
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Abstract
Objective To explore an easily-controled, environmentally benign synthetic method of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one. Methods 4-phenyl-5-ethoxy-carbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one was synthesized from benzaldehyde, ethyl acetoacetate and urea through the Biginelli reaction catalysed by two different ionic liquid (1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium (L)-lactate) under microwave irradiation without a solvent respectively. Results Both ionic liquid catalysts could catalyse Biginelli reaction to get the title compound under microwave irradiation without a solvent. Compared with 1-butyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium (L)-lactate was a better catalyst to get a more satisfied yield of the title compound. Conclusion Microwave accelerated solvent-free Biginelli reaction using green ionic liquid of 1-butyl-3-methylimidazolium (L)-lactate as catalyst was a convenient and environmentally benign synthetic method of 4-phenyl-5-ethoxycarbonyl-6-methyl-3,4-dihydropirimidine-2(1H)-one.
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