The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase

LV Xiao-Qun; ZHANG Ruo-Yu; MIAO Chao-Yu

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Volume 29 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2011 > 29(1): 11-14

LV Xiao-Qun, ZHANG Ruo-Yu, MIAO Chao-Yu. The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 11-14.

Citation:

LV Xiao-Qun, ZHANG Ruo-Yu, MIAO Chao-Yu. The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 11-14.

The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase

Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433 , China

Received Date: 2010-04-20
Rev Recd Date: 2010-05-10

Abstract

nicotinamide phosphoribosyl transferase (Nampt) is an essential protein with a variety of physiological functions and performs potential functions on many diseases such as cardiovascular diseases, diabetes, cancer and autoimmune diseases. It is of great significance to clarify the effect of physiological and pathological statuses as well as compounds on the expression level of Nampt, as it will promote the basic and applied researches. A systematic review about various factors regulating the transcription and expression of Nampt were carried out in this paper.
- Nampt,
- regulation,
- physiology,
- pathology,
- compounds

References

[1]	Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: A protein secreted by visceral fat that mimics the effects of insulin[J]. Science, 2005, 307(5708):426.
[2]	Revollo JR, Korner A, Mills KF, et al. Nampt/PBEF/visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme[J]. Cell Metabolism, 2007, 6(5):363.
[3]	Van der VE, Ho C, O'Neil C, et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase[J]. Journal of Biological Chemistry, 2007, 282(15):10841.
[4]	Yang HY, Yang T, Baur JA, et al. Nutrient-sensitive mitochondrial NAD(+) levels dictate cell survival[J]. Cell, 2007, 130(6):1095.
[5]	Kendal CE, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor (PBEF/visfatin) gene expression is modulated by NF-kB and AP-1 in human amniotic epithelial cells[J]. Placenta, 2007, 28(4):305.
[6]	Luk T, Malam Z, Marshall JC. Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity[J]. J Leukoc Biol, 2008, 83(4):804.
[7]	Wang T, Zhang X, Bheda P, et al. Structure of nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme[J]. Nat Struct Mol Biol, 2006, 13(7):661.
[8]	Frydelund-Larsen L, Akerstrom T, Nielsen S, et al. Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise[J]. Am J Physiol Endocrinol Metab, 2007, 292(1):E24.
[9]	Pilz S, Mangge H, Obermayer-Pietsch B, et al. Visfatin/pre-B-cell colony-enhancing factor:a protein with various suggested functions[J]. J Endocrinol Invest, 2007, 30(2):138.
[10]	Ando H, Yanagihara H, Hayashi Y, et al. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue[J]. Endocrinology, 2005, 146(12):5631.
[11]	Haider DG, Schindler K, Schaller G, et al. Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding[J]. J Clin Endocrinol Metab, 2006, 91(4):1578.
[12]	Sun G, Bishop J, Khalili S, et al. Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men[J]. Am J Clin Nutr, 2007, 85(2):399.
[13]	Pagano C, Pilon C, Olivieri M, et al. Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans[J]. J Clin EndocrinolMetab,2006, 91(8):3165.
[14]	Botella-Carretero JI, Luque-Ramirez M, lvarez-Blasco F, et al. The increase in serum visfatin after bariatric surgery in morbidly obese women is modulated by weight loss, waist circumference, and presence or absence of diabetes before surgery[J]. Obes Surg, 2008, 18(8):1000.
[15]	Berndt J, Kloting N, Kralisch S, et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans[J]. Diabetes,2005,54(10):2911.
[16]	Hammarstedt A, Pihlajamaki J, Sopasakis VR, et al. Visfatin is an adipokine, but it is not regulated by thiazolidinediones[J]. J Clin Endocrinol Metab, 2006, 91(3):1181.
[17]	Unluturk U, Harmanci A, Yildiz BO, et al. Dynamics of nampt/visfatin and high molecular weight adiponectin in response to oral glucose load in obese and lean women[J]. Clin Endocrinol (Oxf),2009.
[18]	Segawa K, Fukuhara A, Hosogai N, et al. Visfatin in adipocytes is upregulated by hypoxia through HIF1α-dependent mechanism[J]. Biochem Biophys Res Commun, 2006, 349(3):875.
[19]	Bae SK, Kima SR, Kim JG, et al. Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1[J]. FEBS Lett, 2006, 580(17):4105.
[20]	Dahl TB, Yndestad A, Skjelland M, et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: Possible role in inflammation and plaque destabilization[J]. Circulation, 2007, 115(8):972.
[21]	Nakajima TE, Yamada Y, Hamano T, et al. Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer[J]. J Gastroenterol, 2009, 44(7):685.
[22]	De Boer JF, Bahr MJ, B?ker KH, et al. Plasma levels of PBEF/nampt/visfatin are decreased in patients with liver cirrhosis[J]. Am J Physiol Gastrointest Liver Physiol, 2009, 296(2): G196.
[23]	Olesen UH, Christensen MK, Bjorkling F, et al. Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochemical and Biophysical Research Communications, 2008, 367(4):799.
[24]	Ognjanovic S, Bao S, Yamamoto SY, et al. Genomic organization of the gene coding for human pre-B-cell colony enhnancing factor and expression in human fetal membranes[J]. J Mol Endocrinol, 2001, 26(2):107.
[25]	Bauer L, Venz S, Junker H, et al. Nicotinamide phosphoribosyltransferase and prostaglandin H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells after stimulation with interleukin-1[J]. Int J Oncol, 2009, 35(1):97.
[26]	Kralisch S, Klein J, Lossner U, et al. Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes[J]. J Endocrinol, 2005, 185(3):R1.
[27]	Ognjanovic S, Ku TL, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium[J]. Am J Obstet Gynecol, 2005, 193(1):273.
[28]	MacLaren R, Cui W, Cianflone K. Visfatin expression is hormonally regulated by metabolicand sex hormones in 3T3-L1 pre-adipocytes and adipocytes[J]. Diabetes Obes Metab, 2007, 9(4):490.
[29]	Zhou H, Yang X, Wang NL, et al. Macrostemonoside A promotes visfatin expression in 3T3-L1 cells[J]. Biol Pharm Bull,2007,30(2):279.
[30]	Mukherjee S, Lekli I, Gurusamy N, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol[J]. Free Radic Biol Med, 2009, 46(5):573.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase

Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433 , China

Received Date: 2010-04-20

Rev Recd Date: 2010-05-10

Key words:

Nampt /
regulation /
physiology /
pathology /
compounds

Abstract: nicotinamide phosphoribosyl transferase (Nampt) is an essential protein with a variety of physiological functions and performs potential functions on many diseases such as cardiovascular diseases, diabetes, cancer and autoimmune diseases. It is of great significance to clarify the effect of physiological and pathological statuses as well as compounds on the expression level of Nampt, as it will promote the basic and applied researches. A systematic review about various factors regulating the transcription and expression of Nampt were carried out in this paper.

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Reference (30)

[1]	Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: A protein secreted by visceral fat that mimics the effects of insulin[J]. Science, 2005, 307(5708):426.
[2]	Revollo JR, Korner A, Mills KF, et al. Nampt/PBEF/visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme[J]. Cell Metabolism, 2007, 6(5):363.
[3]	Van der VE, Ho C, O'Neil C, et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase[J]. Journal of Biological Chemistry, 2007, 282(15):10841.
[4]	Yang HY, Yang T, Baur JA, et al. Nutrient-sensitive mitochondrial NAD(+) levels dictate cell survival[J]. Cell, 2007, 130(6):1095.
[5]	Kendal CE, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor (PBEF/visfatin) gene expression is modulated by NF-kB and AP-1 in human amniotic epithelial cells[J]. Placenta, 2007, 28(4):305.
[6]	Luk T, Malam Z, Marshall JC. Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity[J]. J Leukoc Biol, 2008, 83(4):804.
[7]	Wang T, Zhang X, Bheda P, et al. Structure of nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme[J]. Nat Struct Mol Biol, 2006, 13(7):661.
[8]	Frydelund-Larsen L, Akerstrom T, Nielsen S, et al. Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise[J]. Am J Physiol Endocrinol Metab, 2007, 292(1):E24.
[9]	Pilz S, Mangge H, Obermayer-Pietsch B, et al. Visfatin/pre-B-cell colony-enhancing factor:a protein with various suggested functions[J]. J Endocrinol Invest, 2007, 30(2):138.
[10]	Ando H, Yanagihara H, Hayashi Y, et al. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue[J]. Endocrinology, 2005, 146(12):5631.
[11]	Haider DG, Schindler K, Schaller G, et al. Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding[J]. J Clin Endocrinol Metab, 2006, 91(4):1578.
[12]	Sun G, Bishop J, Khalili S, et al. Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men[J]. Am J Clin Nutr, 2007, 85(2):399.
[13]	Pagano C, Pilon C, Olivieri M, et al. Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans[J]. J Clin EndocrinolMetab,2006, 91(8):3165.
[14]	Botella-Carretero JI, Luque-Ramirez M, lvarez-Blasco F, et al. The increase in serum visfatin after bariatric surgery in morbidly obese women is modulated by weight loss, waist circumference, and presence or absence of diabetes before surgery[J]. Obes Surg, 2008, 18(8):1000.
[15]	Berndt J, Kloting N, Kralisch S, et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans[J]. Diabetes,2005,54(10):2911.
[16]	Hammarstedt A, Pihlajamaki J, Sopasakis VR, et al. Visfatin is an adipokine, but it is not regulated by thiazolidinediones[J]. J Clin Endocrinol Metab, 2006, 91(3):1181.
[17]	Unluturk U, Harmanci A, Yildiz BO, et al. Dynamics of nampt/visfatin and high molecular weight adiponectin in response to oral glucose load in obese and lean women[J]. Clin Endocrinol (Oxf),2009.
[18]	Segawa K, Fukuhara A, Hosogai N, et al. Visfatin in adipocytes is upregulated by hypoxia through HIF1α-dependent mechanism[J]. Biochem Biophys Res Commun, 2006, 349(3):875.
[19]	Bae SK, Kima SR, Kim JG, et al. Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1[J]. FEBS Lett, 2006, 580(17):4105.
[20]	Dahl TB, Yndestad A, Skjelland M, et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: Possible role in inflammation and plaque destabilization[J]. Circulation, 2007, 115(8):972.
[21]	Nakajima TE, Yamada Y, Hamano T, et al. Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer[J]. J Gastroenterol, 2009, 44(7):685.
[22]	De Boer JF, Bahr MJ, B?ker KH, et al. Plasma levels of PBEF/nampt/visfatin are decreased in patients with liver cirrhosis[J]. Am J Physiol Gastrointest Liver Physiol, 2009, 296(2): G196.
[23]	Olesen UH, Christensen MK, Bjorkling F, et al. Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochemical and Biophysical Research Communications, 2008, 367(4):799.
[24]	Ognjanovic S, Bao S, Yamamoto SY, et al. Genomic organization of the gene coding for human pre-B-cell colony enhnancing factor and expression in human fetal membranes[J]. J Mol Endocrinol, 2001, 26(2):107.
[25]	Bauer L, Venz S, Junker H, et al. Nicotinamide phosphoribosyltransferase and prostaglandin H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells after stimulation with interleukin-1[J]. Int J Oncol, 2009, 35(1):97.
[26]	Kralisch S, Klein J, Lossner U, et al. Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes[J]. J Endocrinol, 2005, 185(3):R1.
[27]	Ognjanovic S, Ku TL, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium[J]. Am J Obstet Gynecol, 2005, 193(1):273.
[28]	MacLaren R, Cui W, Cianflone K. Visfatin expression is hormonally regulated by metabolicand sex hormones in 3T3-L1 pre-adipocytes and adipocytes[J]. Diabetes Obes Metab, 2007, 9(4):490.
[29]	Zhou H, Yang X, Wang NL, et al. Macrostemonoside A promotes visfatin expression in 3T3-L1 cells[J]. Biol Pharm Bull,2007,30(2):279.
[30]	Mukherjee S, Lekli I, Gurusamy N, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol[J]. Free Radic Biol Med, 2009, 46(5):573.

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The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase

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通讯作者: 陈斌, bchen63@163.com

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