Application of micro-dialysis-LC/MS in pharmaceutical analysis

LV Di-ya; HONG Zhan-ying; LOU Zi-yang; CAO Yan; DONG Xing; CHAI Yi-feng

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Volume 29 Issue 2

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2011 > 29(2): 93-96,119

LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.

Citation:

LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.

Application of micro-dialysis-LC/MS in pharmaceutical analysis

School of Pharmacy, Second Military Medical University ,Shanghai 200433, China

Received Date: 2010-09-26
Rev Recd Date: 2010-12-30

Abstract

Objective To review the micro-dialysis coupled with chromatographic technologies in pharmaceutical analysis in vivo. Methods The relevant literatures were collected to make a summary of microdialysis coupled with chromatography technology in pharmaceutical analysis in vivo. Results and Conclusions As a new sampling technology, microdialysis coupled with LC-MS had advantages of high sensitive, fast, simple, less interference, and no sample preparation. This technology had been rapidly promoted and applied, especially in the pharmacokinetic-pharmacodynamic studies which had broad application prospects.
- microdialysis,
- LC-MS

References

[1]	Bourne JA Intracerebral microdialysis: 30 years as a tool for the neuroscientist[J]. Clin Exp Pharmacol Physiol, 2003, 30(1-2): 16.
[2]	Holovics HJ, Anderson CR , Levine BS, et al. Investigation of drug delivery by iontophoresis in a surgical wound utilizing microdialysis[J]. Pharm Res, 2008, 25(8): 1762.
[3]	Kim A, Suecof LA, Sutherland CA,et al. In vivo microdialysis study of the penetration of daptomycin into soft tissues in diabetic versus healthy volunteers[J]. Antimicrob Agents Chemother, 2008, 52(11): 3941.
[4]	Bielecka Grzela S, Klimowicz A. Application of cutaneous microdialysis to evaluate metronidazole and its main metabolite concentrations in the skin after a single oral dose[J]. J Clin Pharm Ther, 2003, 28(6): 465.
[5]	Lanckmans K, Clinckers R, Van Eeckhaut A, et al. Use of microbore LC-MS/MS for the quantification of oxcarbazepine and its active metabolite in rat brain microdialysis samples[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 831(1-2): 205.
[6]	Mathy FX, Vroman B, Ntivunwa D,et al. On-line determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2003, 787(2): 323.
[7]	O'Brien KB, Esguerra M , Klug CT,et al. A high-throughput on-line microdialysis-capillary assay for D-serine[J]. Electrophoresis,2003, 24(7-8): 1227.
[8]	郑红. 微透析与现代分析技术联用的研究进展[J]. 国外医学:药学分册, 2005, 32(4): 275.
[9]	Richards DA, Silva MA, Murphy N, et al. Extracellular amino acid levels in the human liver during transplantation: a microdialysis study from donor to recipient[J]. Amino Acids, 2007, 33(3): 429.
[10]	Davies MI, Lunte CE. Simultaneous microdialysis sampling from multiple sites in the liver for the study of phenol metabolism[J]. Life Sci,1996, 59(12): 1001.
[11]	Gilinsky MA, Faibushevish AA , Lunte CE. Determination of myocardial norepinephrine in freely moving rats using in vivo microdialysis sampling and liquid chromatography with dual-electrode amperometric detection[J]. J Pharm Biomed Anal, 2001, 24(5-6): 929.
[12]	Price KE, Vandaveer SS, Lunte CE,et al. Tissue targeted metabonomics: metabolic profiling by microdialysis sampling and microcoil NMR[J]. J Pharm Biomed Anal, 2005, 38(5): 904.
[13]	Lin LC, Hung LC, Tsai TH. Determination of (-)-epigallocatechin gallate in rat blood by microdialysis coupled with liquid chromatography[J]. J Chromatogr A, 2004, 1032(1-2): 125.
[14]	Huang H, Zhang Y, Yang R,et al. Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci,2008, 874(1-2): 77.
[15]	Ward KW, Pollack GM. Use of intrauterine microdialysis to investigate methanol-induced alterations in uteroplacental blood flow[J]. Toxicol Appl Pharmacol,1996, 140(2): 203.
[16]	Woo KL, Lunte CE. The development of multiple probe microdialysis sampling in the stomach[J]. J Pharm Biomed Anal, 2008, 48(1): 20.
[17]	Woo KL, Lunte CE. The direct comparison of health and ulcerated stomach tissue: a multiple probe microdialysis sampling approach[J]. J Pharm Biomed Anal, 2008, 48(1): 85.
[18]	Zhu T, Cheung BW, Cartier LL, et al. Simultaneous intravenous and intramiddle-ear dosing to determine cefditoren influx and efflux clearances in middle ear fluid in freely moving chinchillas[J]. J Pharm Sci, 2003, 92(10): 1947.
[19]	Ault JM, Riley CM, Meltzer NM,et al. Dermal microdialysis sampling in vivo[J]. Pharm Res, 1994, 11(11): 1631.
[20]	Kottegoda S, Shaik I, Shippy SA. Demonstration of low flow push-pull perfusion[J]. J Neurosci Methods, 2002, 121(1): 93.
[21]	朱林. 微透析取样技术及其在药代动力学中的应用[J]. 国外医学:药学分册, 2002, 29(5): 296.
[22]	Huff JK, Davies MI. Microdialysis monitoring of methylphenidate in blood and brain correlated with changes in dopamine and rat activity[J]. J Pharm Biomed Anal,2002, 29(5): 767.
[23]	Brunner M, Derendorf H. Clinical microdialysis: Current applications and potential use in drug development[J]. TrAC Trends in Analytical Chemistry, 2006, 25(7): 674.
[24]	Benveniste H, Drejer J, Schousboe A,et al. Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat[J]. J Neurochem, 1987, 49(3): 729.
[25]	Jin G, Cheng Q, Feng J,et al. On-line microdialysis coupled to analytical systems[J]. J Chromatogr Sci, 2008, 46(3): 276.
[26]	Tseng WC, Yang MH, Chen TP, et al. Automated, continuous, and dynamic speciation of urinary arsenic in the bladder of living organisms using microdialysis sampling coupled on-line with high performance liquid chromatography and hydride generation atomic absorption spectrometry[J]. Analyst, 2002, 127(4): 560.
[27]	Yang CS, Tsai PJ, Chen WY, et al. On-line, continuous and automatic monitoring of extracellular malondialdehyde concentration in anesthetized rat brain cortex[J]. J Chromatogr B Biomed Sci Appl, 2001, 752(1): 33.
[28]	Hows ME, Organ AJ, Murray S,et al. High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates[J]. J Neurosci Methods, 2002, 121(1): 33.
[29]	Bito L, Davson H, Levin E, et al. The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog[J]. J Neurochem,1966, 13(11): 1057.
[30]	Zhang MY, Beyer CE. Measurement of neurotransmitters from extracellular fluid in brain by in vivo microdialysis and chromatography-mass spectrometry[J]. J Pharm Biomed Anal, 2006, 40(3): 492.
[31]	赵先恩,索有瑞. 大鼠端脑中神经递质的荧光衍生化高效液相色谱质谱联用法研究[J]. 分析化学, 2008, 36(1): 12.
[32]	Ji C, Li W, Ren XD,et al. Diethylation labeling combined with UPLC/MS/MS for simultaneous determination of a panel of monoamine neurotransmitters in rat prefrontal cortex microdialysates[J]. Anal Chem, 2008, 80(23): 9195.
[33]	Zhang MY, Hughes ZA, Kerns EH, et al. Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples[J]. J Pharm Biomed Anal, 2007, 44(2): 586.
[34]	Qu Y, Aluisio L, Lord B,et al. Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex[J]. Pharmacol Biochem Behav, 2009, 92(3): 469.
[35]	Guo P, Wang X, Liu L,et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry[J]. J Pharm Biomed Anal, 2007, 43(5): 1789.
[36]	马仁玲,周红华,于喜水,等. 苦参注射液生物碱类成分指纹图谱的研究[J]. 中国中药杂志, 2003, 28(9): 817.
[37]	刘梅,刘雪英,程建峰. 苦参碱的药理研究进展[J]. 中国中药杂志, 2003, 28(9): 801.
[38]	陈亚飞,田颂九,孙曾培. 复方石韦片中生物碱的分离测定[J]. 药物分析杂志, 2002, 22(2): 94.
[39]	祝德秋,施安国. 苦参素注射液的人体药动学[J]. 中国医院药学杂志, 2003, 23(1): 21.
[40]	孟根达来,王毅,贾福群. 反相离子对高效液相色谱法测定人血浆中苦参碱和氧化苦参碱[J]. 药物分析杂志, 2003, 23(6): 440.
[41]	Zheng H, Chen G, Shi L, et al. Determination of oxymatrine and its metabolite matrine in rat blood and dermal microdialysates by high throughput liquid chromatography/tandem mass spectrometry[J]. J Pharm Biomed Anal, 2009, 49(2): 427.
[42]	Ye G, Li YZ, Li YY,et al. SPE-HPLC method for the determination and pharmacokinetic studies on paeoniflorin in rat serum after oral administration of traditional Chinese medicinal preparation Guan-Xin-Er-Hao decoction[J]. J Pharm Biomed Anal, 2003, 33(3): 521.
[43]	Guo M, Su X, Kong L, et al. Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC[J]. Anal Chim Acta, 2006, 556(1): 183.
[44]	Su X, Kong L, Li X,et al. Screening and analysis of bioactive compounds with biofingerprinting chromatogram analysis of traditional Chinese medicines targeting DNA by microdialysis/HPLC[J]. J Chromatogr A, 2005, 1076(1-2): 118.
[45]	Li SL, Li P, Sheng LH,et al. Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines[J]. J Pharm Biomed Anal, 2006, 41(2): 576.
[46]	Wen XD, Qi LW, Chen J,et al. Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 852(1-2): 598.
[47]	艾华, 王广基, 顾轶, 等. 超高效液相色谱在现代药代动力学中的应用[J]. 中国药科大学学报, 2007, 38(4): 294.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Application of micro-dialysis-LC/MS in pharmaceutical analysis

School of Pharmacy, Second Military Medical University ,Shanghai 200433, China

Received Date: 2010-09-26

Rev Recd Date: 2010-12-30

Key words:

microdialysis /
LC-MS

Abstract: Objective To review the micro-dialysis coupled with chromatographic technologies in pharmaceutical analysis in vivo. Methods The relevant literatures were collected to make a summary of microdialysis coupled with chromatography technology in pharmaceutical analysis in vivo. Results and Conclusions As a new sampling technology, microdialysis coupled with LC-MS had advantages of high sensitive, fast, simple, less interference, and no sample preparation. This technology had been rapidly promoted and applied, especially in the pharmacokinetic-pharmacodynamic studies which had broad application prospects.

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Reference (47)

[1]	Bourne JA Intracerebral microdialysis: 30 years as a tool for the neuroscientist[J]. Clin Exp Pharmacol Physiol, 2003, 30(1-2): 16.
[2]	Holovics HJ, Anderson CR , Levine BS, et al. Investigation of drug delivery by iontophoresis in a surgical wound utilizing microdialysis[J]. Pharm Res, 2008, 25(8): 1762.
[3]	Kim A, Suecof LA, Sutherland CA,et al. In vivo microdialysis study of the penetration of daptomycin into soft tissues in diabetic versus healthy volunteers[J]. Antimicrob Agents Chemother, 2008, 52(11): 3941.
[4]	Bielecka Grzela S, Klimowicz A. Application of cutaneous microdialysis to evaluate metronidazole and its main metabolite concentrations in the skin after a single oral dose[J]. J Clin Pharm Ther, 2003, 28(6): 465.
[5]	Lanckmans K, Clinckers R, Van Eeckhaut A, et al. Use of microbore LC-MS/MS for the quantification of oxcarbazepine and its active metabolite in rat brain microdialysis samples[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 831(1-2): 205.
[6]	Mathy FX, Vroman B, Ntivunwa D,et al. On-line determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2003, 787(2): 323.
[7]	O'Brien KB, Esguerra M , Klug CT,et al. A high-throughput on-line microdialysis-capillary assay for D-serine[J]. Electrophoresis,2003, 24(7-8): 1227.
[8]	郑红. 微透析与现代分析技术联用的研究进展[J]. 国外医学:药学分册, 2005, 32(4): 275.
[9]	Richards DA, Silva MA, Murphy N, et al. Extracellular amino acid levels in the human liver during transplantation: a microdialysis study from donor to recipient[J]. Amino Acids, 2007, 33(3): 429.
[10]	Davies MI, Lunte CE. Simultaneous microdialysis sampling from multiple sites in the liver for the study of phenol metabolism[J]. Life Sci,1996, 59(12): 1001.
[11]	Gilinsky MA, Faibushevish AA , Lunte CE. Determination of myocardial norepinephrine in freely moving rats using in vivo microdialysis sampling and liquid chromatography with dual-electrode amperometric detection[J]. J Pharm Biomed Anal, 2001, 24(5-6): 929.
[12]	Price KE, Vandaveer SS, Lunte CE,et al. Tissue targeted metabonomics: metabolic profiling by microdialysis sampling and microcoil NMR[J]. J Pharm Biomed Anal, 2005, 38(5): 904.
[13]	Lin LC, Hung LC, Tsai TH. Determination of (-)-epigallocatechin gallate in rat blood by microdialysis coupled with liquid chromatography[J]. J Chromatogr A, 2004, 1032(1-2): 125.
[14]	Huang H, Zhang Y, Yang R,et al. Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci,2008, 874(1-2): 77.
[15]	Ward KW, Pollack GM. Use of intrauterine microdialysis to investigate methanol-induced alterations in uteroplacental blood flow[J]. Toxicol Appl Pharmacol,1996, 140(2): 203.
[16]	Woo KL, Lunte CE. The development of multiple probe microdialysis sampling in the stomach[J]. J Pharm Biomed Anal, 2008, 48(1): 20.
[17]	Woo KL, Lunte CE. The direct comparison of health and ulcerated stomach tissue: a multiple probe microdialysis sampling approach[J]. J Pharm Biomed Anal, 2008, 48(1): 85.
[18]	Zhu T, Cheung BW, Cartier LL, et al. Simultaneous intravenous and intramiddle-ear dosing to determine cefditoren influx and efflux clearances in middle ear fluid in freely moving chinchillas[J]. J Pharm Sci, 2003, 92(10): 1947.
[19]	Ault JM, Riley CM, Meltzer NM,et al. Dermal microdialysis sampling in vivo[J]. Pharm Res, 1994, 11(11): 1631.
[20]	Kottegoda S, Shaik I, Shippy SA. Demonstration of low flow push-pull perfusion[J]. J Neurosci Methods, 2002, 121(1): 93.
[21]	朱林. 微透析取样技术及其在药代动力学中的应用[J]. 国外医学:药学分册, 2002, 29(5): 296.
[22]	Huff JK, Davies MI. Microdialysis monitoring of methylphenidate in blood and brain correlated with changes in dopamine and rat activity[J]. J Pharm Biomed Anal,2002, 29(5): 767.
[23]	Brunner M, Derendorf H. Clinical microdialysis: Current applications and potential use in drug development[J]. TrAC Trends in Analytical Chemistry, 2006, 25(7): 674.
[24]	Benveniste H, Drejer J, Schousboe A,et al. Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat[J]. J Neurochem, 1987, 49(3): 729.
[25]	Jin G, Cheng Q, Feng J,et al. On-line microdialysis coupled to analytical systems[J]. J Chromatogr Sci, 2008, 46(3): 276.
[26]	Tseng WC, Yang MH, Chen TP, et al. Automated, continuous, and dynamic speciation of urinary arsenic in the bladder of living organisms using microdialysis sampling coupled on-line with high performance liquid chromatography and hydride generation atomic absorption spectrometry[J]. Analyst, 2002, 127(4): 560.
[27]	Yang CS, Tsai PJ, Chen WY, et al. On-line, continuous and automatic monitoring of extracellular malondialdehyde concentration in anesthetized rat brain cortex[J]. J Chromatogr B Biomed Sci Appl, 2001, 752(1): 33.
[28]	Hows ME, Organ AJ, Murray S,et al. High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates[J]. J Neurosci Methods, 2002, 121(1): 33.
[29]	Bito L, Davson H, Levin E, et al. The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog[J]. J Neurochem,1966, 13(11): 1057.
[30]	Zhang MY, Beyer CE. Measurement of neurotransmitters from extracellular fluid in brain by in vivo microdialysis and chromatography-mass spectrometry[J]. J Pharm Biomed Anal, 2006, 40(3): 492.
[31]	赵先恩,索有瑞. 大鼠端脑中神经递质的荧光衍生化高效液相色谱质谱联用法研究[J]. 分析化学, 2008, 36(1): 12.
[32]	Ji C, Li W, Ren XD,et al. Diethylation labeling combined with UPLC/MS/MS for simultaneous determination of a panel of monoamine neurotransmitters in rat prefrontal cortex microdialysates[J]. Anal Chem, 2008, 80(23): 9195.
[33]	Zhang MY, Hughes ZA, Kerns EH, et al. Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples[J]. J Pharm Biomed Anal, 2007, 44(2): 586.
[34]	Qu Y, Aluisio L, Lord B,et al. Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex[J]. Pharmacol Biochem Behav, 2009, 92(3): 469.
[35]	Guo P, Wang X, Liu L,et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry[J]. J Pharm Biomed Anal, 2007, 43(5): 1789.
[36]	马仁玲,周红华,于喜水,等. 苦参注射液生物碱类成分指纹图谱的研究[J]. 中国中药杂志, 2003, 28(9): 817.
[37]	刘梅,刘雪英,程建峰. 苦参碱的药理研究进展[J]. 中国中药杂志, 2003, 28(9): 801.
[38]	陈亚飞,田颂九,孙曾培. 复方石韦片中生物碱的分离测定[J]. 药物分析杂志, 2002, 22(2): 94.
[39]	祝德秋,施安国. 苦参素注射液的人体药动学[J]. 中国医院药学杂志, 2003, 23(1): 21.
[40]	孟根达来,王毅,贾福群. 反相离子对高效液相色谱法测定人血浆中苦参碱和氧化苦参碱[J]. 药物分析杂志, 2003, 23(6): 440.
[41]	Zheng H, Chen G, Shi L, et al. Determination of oxymatrine and its metabolite matrine in rat blood and dermal microdialysates by high throughput liquid chromatography/tandem mass spectrometry[J]. J Pharm Biomed Anal, 2009, 49(2): 427.
[42]	Ye G, Li YZ, Li YY,et al. SPE-HPLC method for the determination and pharmacokinetic studies on paeoniflorin in rat serum after oral administration of traditional Chinese medicinal preparation Guan-Xin-Er-Hao decoction[J]. J Pharm Biomed Anal, 2003, 33(3): 521.
[43]	Guo M, Su X, Kong L, et al. Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC[J]. Anal Chim Acta, 2006, 556(1): 183.
[44]	Su X, Kong L, Li X,et al. Screening and analysis of bioactive compounds with biofingerprinting chromatogram analysis of traditional Chinese medicines targeting DNA by microdialysis/HPLC[J]. J Chromatogr A, 2005, 1076(1-2): 118.
[45]	Li SL, Li P, Sheng LH,et al. Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines[J]. J Pharm Biomed Anal, 2006, 41(2): 576.
[46]	Wen XD, Qi LW, Chen J,et al. Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 852(1-2): 598.
[47]	艾华, 王广基, 顾轶, 等. 超高效液相色谱在现代药代动力学中的应用[J]. 中国药科大学学报, 2007, 38(4): 294.

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Application of micro-dialysis-LC/MS in pharmaceutical analysis

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通讯作者: 陈斌, bchen63@163.com

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