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Volume 29 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(3): 204-205,218

WANG Jian-fang, SUN Cai-ping, CHEN Xia-lin. Therapeutic efficacy of indometacin in treatment of pain related to radiation-induced mucositis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 204-205,218.
Citation: WANG Jian-fang, SUN Cai-ping, CHEN Xia-lin. Therapeutic efficacy of indometacin in treatment of pain related to radiation-induced mucositis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 204-205,218.
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Therapeutic efficacy of indometacin in treatment of pain related to radiation-induced mucositis

  • Shaoxing People's Hospital,Shaoxing 312000,China

  • Received Date: 2010-07-06
  • Rev Recd Date: 2010-10-24
  • Objective To evaluate the efficacy of indometacin in treatment of pain syndrome related to radiation-induced mucositis. Methods Fifty-eight cases of head and neck malignancies with radio-therapeutic mucositis pain were randomly divided into two groups: one group were treated with both indometacin and normal therapy, the other group received normal therapy. Results By using the indometacin, the pain relief rate during the radiotherapy was 89.7%, which was 27.6% in control group. In the treatment group, the body weight stable ratio in radiation and after radiation are 69.0% and 37.9%, which was 34.5% and 17.2% in control group. The chief side effects were reduced. Conclusion Indometacin could relieve pain with radio-therapeutic mucositis pain in radiotherapy to head and neck malignancies treated and should be further evaluated prospectively in controlled clinical trials.
  • [1] Ang kk. Altered fractionation in the management of head and neck cancer[J]. Int J Radiat Biol, 1998, 73 (4) : 395. [2] 谭榜宪,张有望,胡超苏,等.鼻咽癌常规分割放疗中的时间剂量效应关系[J].中华放射疼痛学杂志,1998 ,7(1) :41. [3] Weissman DE ,Janjan N,Byhardt RW,et al.Assessment of pain during head and neck irradiation[J].J Pain Symptom Manage,1989,4(2):90. [4] 程 晶,马 虹,薛 军,等.芬太尼透皮帖剂治疗鼻咽癌放疗相关性口腔粘膜炎所致疼痛的疗效观察[J].肿瘤防治研究,2008,35(6):442. [5] 高文君,郑慧娟,叶纯华,等. 吲哚美辛栓缓解Ⅲ型前列腺炎患者疼痛症状的初步观察[J].浙江临床医学,2007,9(5):607. [6] Gallo O,Franchi A,Magnelli L.Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer ,Implications for tumor angiogenesis and metastasis[J].Neoplasia,2001,3:53.
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Therapeutic efficacy of indometacin in treatment of pain related to radiation-induced mucositis

  • Shaoxing People's Hospital,Shaoxing 312000,China
  • Received Date: 2010-07-06
  • Rev Recd Date: 2010-10-24

Abstract: Objective To evaluate the efficacy of indometacin in treatment of pain syndrome related to radiation-induced mucositis. Methods Fifty-eight cases of head and neck malignancies with radio-therapeutic mucositis pain were randomly divided into two groups: one group were treated with both indometacin and normal therapy, the other group received normal therapy. Results By using the indometacin, the pain relief rate during the radiotherapy was 89.7%, which was 27.6% in control group. In the treatment group, the body weight stable ratio in radiation and after radiation are 69.0% and 37.9%, which was 34.5% and 17.2% in control group. The chief side effects were reduced. Conclusion Indometacin could relieve pain with radio-therapeutic mucositis pain in radiotherapy to head and neck malignancies treated and should be further evaluated prospectively in controlled clinical trials.

WANG Jian-fang, SUN Cai-ping, CHEN Xia-lin. Therapeutic efficacy of indometacin in treatment of pain related to radiation-induced mucositis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 204-205,218.
Citation: WANG Jian-fang, SUN Cai-ping, CHEN Xia-lin. Therapeutic efficacy of indometacin in treatment of pain related to radiation-induced mucositis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 204-205,218.
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