Progress of molecular imprinting technique in drug separation

KONG Dan-feng; ZHAO Wen; LU Ting-li; HUI Qian-qian; WANG Yun-qing; CHEN Tao

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Volume 29 Issue 3

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2011 > 29(3): 161-164

KONG Dan-feng, ZHAO Wen, LU Ting-li, HUI Qian-qian, WANG Yun-qing, CHEN Tao. Progress of molecular imprinting technique in drug separation[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 161-164.

Citation:

KONG Dan-feng, ZHAO Wen, LU Ting-li, HUI Qian-qian, WANG Yun-qing, CHEN Tao. Progress of molecular imprinting technique in drug separation[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 161-164.

Progress of molecular imprinting technique in drug separation

1.
Key Laboratory for Space Biosciences & Biotechnology Faculty of Life Science, Northwestern Polytechnical University, Xi'an 710072, China
2.
Key Laboratory for Space Biosciences & Biotechnology Faculty of Life Science, Northwestern Polytechnical University, Xi'an 710072, China;Xi'an Libang Pharmaceuticals Co.,Ltd , Xi'an 710075, China

Received Date: 2010-04-14
Rev Recd Date: 2010-09-25

Abstract

Molecularly imprinted polymer drawn much attention for its specific identification function. Among all the research about MIPS, drug separation takes a large proportion. MIPS played an important role in extracting the target-drug from mixture, separating structure analogues and chiral drug, which enhanced the position of MIPS in the field of drug separation. In this paper, the research of MIPS in drug separation and the choice of MIPS functional monomer had been summarized, and the development direction in the future had also been predicted.
- molecularly imprinted,
- separation,
- chiral drugs,
- protein,
- functional monomer

References

[1]	Wulff G, sarhan A, zabrock I. Enzyme analogue built polymers and their use for the resolution of racemates[J].Tetrahedron Lett, 1973, 44: 4329.
[2]	蔡万锡.天然维生素E提取工艺的比较[J].生化与医药-化工之友,2007,1:48.
[3]	曾哲灵,万冬满,陈力,等.天然维生素E提取工艺研究[J].中国畜产与食品,1997,4(1):27.
[4]	Faizal CKM, Hoshina Y, Kobayashi T.Scaffold membranes for selective adsorption of α-tocopherol by phase inversion covalently imprinting technique[J].Journal of Membrane Science,2008,322:503.
[5]	Faizal CKM, Kikuchic Y, Kobayashi T. Molecular imprinting targeted for α-tocopherol by calix resorcarenes derivative in membrane scaffold prepared by phase inversion[J].Journal of Membrane Science,2009,334:110.
[6]	Piacham T, Nantasenamat C, Suksrichavalit T,et al. Synthesis and theoretical study of molecularly imprinted nanospheres for recognition of tocopherols[J].Molecules,2009,14: 2985.
[7]	Wang P, Hu WM, Su WK. Molecularly imprinted poly(methacrylamide-co-methacrylic acid) composite membranes for recognition of curcumin[J].Analytica Chimica,2008,615:54.
[8]	Zhang YQ, Gao XQ, Wang YL,et al. Study on the build of channels in accurate separation membrane and its selective mechanism[J].Journal of Membrane Science,2009,339:100.
[9]	Zhai CX, Lu Q, Chen XM,et al. Molecularly imprinted layer-coated silica nanoparticles toward highly selective separation of active diosgenin from dioscorea nipponica makino[J]. Journal of Chromatography A,2009,1216:2254.
[10]	曹永兵,雷孝,王锦,等. 分子印迹技术在药学中的应用进展[J].广州化学,2008,33(4):56.
[11]	Ansell RJ. Molecularly imprinted polymers for the enantioseparation of chiral drugs[J].Advanced Drug Delivery Reviews,2005,57:1809.
[12]	Wang JY, Xu ZL, Wu P,et al. Binding constant and transport property of S-naproxen molecularly imprinted composite membrane[J].Journal of Membrane Science,2009,331:84.
[13]	Xu ZY,Wan JF, Liang S,et al. Separation of ursodeoxycholic acid from its isomeric mixture using core-shell molecular imprinting polymer[J].Biochemical Engineering Journal,2008,41:280.
[14]	Wang XJ, Xu ZL, Feng JL,et al. Molecularly imprinted membranes for the recognition of lovastatin acid in aqueous medium by a template analogue imprinting strategy[J].Journal of Membrane Science,2008,313:97.
[15]	Huang JY, Wei ZX, Chen JC. Molecular imprinted polypyrrole nanowires for chiral amino acid recognition[J]. Sensors and Actuators B: Chemical,2008,134:573.
[16]	Panahi R, Vasheghani-Farahani E, Shojaosadati SA. Separation of l-lysine from dilute aqueous solution using molecular imprinting technique[J].Biochemical Engineering Journal,2007,35:352.
[17]	Papaioannou E, Koutsas C, Liakopoulou-Kyriakides M. Molecularly imprinted polymers for RGD selective recognition and separation[J].Amino Acids,2009, 36:563.
[18]	Itou Y, Nakano M, Yoshikawa M. Optical resolution of racemic amino acid derivatives with molecularly imprinted membranes from tetrapetide consisting of glycinyl residues[J].Journal of Membrane Science,2008,325:371.
[19]	石屹峰,边蕾. 以人血清白蛋白为载体的长效蛋白质药物的研究进展[J].中国医药生物技术,2008,3(6):454.
[20]	Li L, HE XW,Chen LX, et al. Preparation of novel bovine hemoglobin surfaceimprinted polystyrene nanoparticles with magnetic susceptibility[J].Science in China Series B: Chemistry,2009,52(9):1402.
[21]	Lu Y, Yan CL, Gao SY. Preparation and recognition of surface molecularly imprinted core-shell microbeads for protein in aqueous solutions[J].Applied Surface Science,2009,255:6061.
[22]	Zhang W, Qin L, He XW, et al.Novel surface modified molecularly imprinted polymer using acryl-β-cyclodextrin and acrylamide as monomers for selective recognition of lysozyme in aqueous solution[J].Journal of Chromatography A,2009,1216:4560.
[23]	Qin L, He XW, Zhang W,et al.Surface-modified polystyrene beads as photografting imprinted polymer matrix for chromatographic separation of protein[J].Journal of Chromatography A,2009,1216:807.
[24]	Bolisaya LD, Culverb JN, Kofinas P. Molecularly imprinted polymers for tobacco mosaic virus recognition[J].Biomaterials,2006,27:4165.
[25]	迟大民,苏立强,邓茜珊,等.分子印迹功能单体选择方法研究进展[J].化工时刊,2009,12(23):55.
[26]	林秋明,何建峰,刘岚,等.不同功能单体合成的分子印迹聚合物识别性能的研究[J].化学研究与应用,2007,10(19):1084.
[27]	Kowalska A, Stobiecka A, Wysocki S.A computational investigation of the interactions between harmane and the functional monomers commonly used in molecular imprinting[J].Journal of Molecular Structure: THEOCHEM,2009,901:88.
[28]	Chen ZD, Wei JX, Wang WC,et al.Separation of tryptophan enantiomers with molecularly imprinted polypyrrole electrode column[J].Chinese Chemical Letters,2010,21:353.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Progress of molecular imprinting technique in drug separation

1. Key Laboratory for Space Biosciences & Biotechnology Faculty of Life Science, Northwestern Polytechnical University, Xi'an 710072, China

2. Key Laboratory for Space Biosciences & Biotechnology Faculty of Life Science, Northwestern Polytechnical University, Xi'an 710072, China;Xi'an Libang Pharmaceuticals Co.,Ltd , Xi'an 710075, China

Received Date: 2010-04-14

Rev Recd Date: 2010-09-25

Key words:

Abstract: Molecularly imprinted polymer drawn much attention for its specific identification function. Among all the research about MIPS, drug separation takes a large proportion. MIPS played an important role in extracting the target-drug from mixture, separating structure analogues and chiral drug, which enhanced the position of MIPS in the field of drug separation. In this paper, the research of MIPS in drug separation and the choice of MIPS functional monomer had been summarized, and the development direction in the future had also been predicted.

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Reference (28)

[1]	Wulff G, sarhan A, zabrock I. Enzyme analogue built polymers and their use for the resolution of racemates[J].Tetrahedron Lett, 1973, 44: 4329.
[2]	蔡万锡.天然维生素E提取工艺的比较[J].生化与医药-化工之友,2007,1:48.
[3]	曾哲灵,万冬满,陈力,等.天然维生素E提取工艺研究[J].中国畜产与食品,1997,4(1):27.
[4]	Faizal CKM, Hoshina Y, Kobayashi T.Scaffold membranes for selective adsorption of α-tocopherol by phase inversion covalently imprinting technique[J].Journal of Membrane Science,2008,322:503.
[5]	Faizal CKM, Kikuchic Y, Kobayashi T. Molecular imprinting targeted for α-tocopherol by calix resorcarenes derivative in membrane scaffold prepared by phase inversion[J].Journal of Membrane Science,2009,334:110.
[6]	Piacham T, Nantasenamat C, Suksrichavalit T,et al. Synthesis and theoretical study of molecularly imprinted nanospheres for recognition of tocopherols[J].Molecules,2009,14: 2985.
[7]	Wang P, Hu WM, Su WK. Molecularly imprinted poly(methacrylamide-co-methacrylic acid) composite membranes for recognition of curcumin[J].Analytica Chimica,2008,615:54.
[8]	Zhang YQ, Gao XQ, Wang YL,et al. Study on the build of channels in accurate separation membrane and its selective mechanism[J].Journal of Membrane Science,2009,339:100.
[9]	Zhai CX, Lu Q, Chen XM,et al. Molecularly imprinted layer-coated silica nanoparticles toward highly selective separation of active diosgenin from dioscorea nipponica makino[J]. Journal of Chromatography A,2009,1216:2254.
[10]	曹永兵,雷孝,王锦,等. 分子印迹技术在药学中的应用进展[J].广州化学,2008,33(4):56.
[11]	Ansell RJ. Molecularly imprinted polymers for the enantioseparation of chiral drugs[J].Advanced Drug Delivery Reviews,2005,57:1809.
[12]	Wang JY, Xu ZL, Wu P,et al. Binding constant and transport property of S-naproxen molecularly imprinted composite membrane[J].Journal of Membrane Science,2009,331:84.
[13]	Xu ZY,Wan JF, Liang S,et al. Separation of ursodeoxycholic acid from its isomeric mixture using core-shell molecular imprinting polymer[J].Biochemical Engineering Journal,2008,41:280.
[14]	Wang XJ, Xu ZL, Feng JL,et al. Molecularly imprinted membranes for the recognition of lovastatin acid in aqueous medium by a template analogue imprinting strategy[J].Journal of Membrane Science,2008,313:97.
[15]	Huang JY, Wei ZX, Chen JC. Molecular imprinted polypyrrole nanowires for chiral amino acid recognition[J]. Sensors and Actuators B: Chemical,2008,134:573.
[16]	Panahi R, Vasheghani-Farahani E, Shojaosadati SA. Separation of l-lysine from dilute aqueous solution using molecular imprinting technique[J].Biochemical Engineering Journal,2007,35:352.
[17]	Papaioannou E, Koutsas C, Liakopoulou-Kyriakides M. Molecularly imprinted polymers for RGD selective recognition and separation[J].Amino Acids,2009, 36:563.
[18]	Itou Y, Nakano M, Yoshikawa M. Optical resolution of racemic amino acid derivatives with molecularly imprinted membranes from tetrapetide consisting of glycinyl residues[J].Journal of Membrane Science,2008,325:371.
[19]	石屹峰,边蕾. 以人血清白蛋白为载体的长效蛋白质药物的研究进展[J].中国医药生物技术,2008,3(6):454.
[20]	Li L, HE XW,Chen LX, et al. Preparation of novel bovine hemoglobin surfaceimprinted polystyrene nanoparticles with magnetic susceptibility[J].Science in China Series B: Chemistry,2009,52(9):1402.
[21]	Lu Y, Yan CL, Gao SY. Preparation and recognition of surface molecularly imprinted core-shell microbeads for protein in aqueous solutions[J].Applied Surface Science,2009,255:6061.
[22]	Zhang W, Qin L, He XW, et al.Novel surface modified molecularly imprinted polymer using acryl-β-cyclodextrin and acrylamide as monomers for selective recognition of lysozyme in aqueous solution[J].Journal of Chromatography A,2009,1216:4560.
[23]	Qin L, He XW, Zhang W,et al.Surface-modified polystyrene beads as photografting imprinted polymer matrix for chromatographic separation of protein[J].Journal of Chromatography A,2009,1216:807.
[24]	Bolisaya LD, Culverb JN, Kofinas P. Molecularly imprinted polymers for tobacco mosaic virus recognition[J].Biomaterials,2006,27:4165.
[25]	迟大民,苏立强,邓茜珊,等.分子印迹功能单体选择方法研究进展[J].化工时刊,2009,12(23):55.
[26]	林秋明,何建峰,刘岚,等.不同功能单体合成的分子印迹聚合物识别性能的研究[J].化学研究与应用,2007,10(19):1084.
[27]	Kowalska A, Stobiecka A, Wysocki S.A computational investigation of the interactions between harmane and the functional monomers commonly used in molecular imprinting[J].Journal of Molecular Structure: THEOCHEM,2009,901:88.
[28]	Chen ZD, Wei JX, Wang WC,et al.Separation of tryptophan enantiomers with molecularly imprinted polypyrrole electrode column[J].Chinese Chemical Letters,2010,21:353.

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Progress of molecular imprinting technique in drug separation

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通讯作者: 陈斌, bchen63@163.com

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