Progress on pharmacological activities and production methods of citrulline

LIU Juan; LU Xin-xin; MENG Hui

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Citrulline was more and more widely used in food and drug industry, health products industry and cosmetics industry because of it's particular pharmacological effects. At present, there were four main methods for producing citrulline: chemical method, extraction method, enzymatic and fermentation method. The pharmacological effects, the application and research current situation about citrulline were summarized in home and abroad. The development prospects of citrulline were predicted.

Progress on pharmacological activities and production methods of citrulline

1. Jiamusi University, Jiamusi 154000,China

2. Department of pharmacy,85th Hospital of PLA, Shanghai 200052, China

Received Date: 2010-10-15

Rev Recd Date: 2011-02-25

Key words:

Abstract: Citrulline was more and more widely used in food and drug industry, health products industry and cosmetics industry because of it's particular pharmacological effects. At present, there were four main methods for producing citrulline: chemical method, extraction method, enzymatic and fermentation method. The pharmacological effects, the application and research current situation about citrulline were summarized in home and abroad. The development prospects of citrulline were predicted.

HTML

Reference (23)

[1]	Mapelli S, Brambilla I, Belloni V, et al. Changes of free amino acids in leaf sap of trees subjected to flooding and frought stresses[J]. Acta Hortic, 2001, 544:233.
[2]	李静.氨基酸保健品最新应用进展初探[J].天津科技,2010,1.
[3]	王江海,刘昕.一种提升南瓜子中瓜氨酸及抗增生因子活性物质含量并将其提取的方法[P].中国专利,031139523,2003-03-20.
[4]	赵力.一种从西瓜皮中提取瓜氨酸的方法[P].中国专利,100721307,2006-11-29.
[5]	Maritza JR, Daniel HP, Ruth BC, et al. Therapeutic use of citrulline in cardiovascular disease[J]. Cardiovascular Drug Reviews,2006, 24(3-4): 275.
[6]	Wu G, Bazer FW, Davis TA, et al. Arginine metabolism and nutrition in growth, health and disease[J]. Amino-Acids,2009, 37(1): 153.
[7]	Sureda A, Cordova A, Ferrer MD, et al. Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and ntric oxide production after exercise[J]. Free-Radic-Res,2009 , 43(9): 828.
[8]	赵力.一种无糖型瓜氨酸口腔喷雾剂及其制备方法[P].中国专利,101178073,2008-12-31.
[9]	赵力.一种无糖型瓜氨酸泡腾片及其制备方法[P].中国专利,101178092,2008-10-31.
[10]	Liu TH, Wu CL, Chiang CW, et al. No effect of short-term arginine supplementation on nitric oxide production, metabolism and perforance in intermittent exercise in athletes[J]. J-Nutr-Biochem,2009, 20(6): 462.
[11]	多伊茨 NE,格林博格NA,卡斯帕KM,等.使用瓜氨酸的治疗[P].中国专利,800123565,2009-04-22.
[12]	莫纳德C,乔丹M,沃尔兰德S,等.瓜氨酸用于治疗营养缺乏状况的用途[P].中国专利,800424825,2009-12-16.
[13]	Osowska S, Moinard C, Neveux N.Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resection[J]. Gut,2004, 53:1781.
[14]	Adolfo Amici, Rodney LL, Lin Tsai, et al. Stadtman conversion of amino acid residues in protein and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation[J]. The Journal of Biological Chemistry, 1989, 264(6):3341.
[15]	牟昳.瓜氨酸制备方法的研究[D].北京化工大学,2004.
[16]	Plimmer. Analysis of proteins estimation of arginine by decomposition with alkali[J]. Biochem, 1916, 115.
[17]	丁威,李爱平,张征林,等.L-瓜氨酸和L-高瓜氨酸的制备[J].化工时刊,2006,20(2):16.
[18]	钱骅,焦洋,赵伯涛,等.栝楼根中L-瓜氨酸的提取和含量测定[J].食品工业科技,2010,7.
[19]	Okumura S, Yokohama S, Shibuya M. Method of production citrulline by bacterial fermentation[P].US3282794, 1966,01.
[20]	Kyowa Hakko Kogyo Co, Ltd.Process of producing L-citrulline[P]. US1176266, 1970,01.
[21]	Gilbert CS, Milan AL, Alfred AT. The degradation of srginine by clostridium perfringens[J]. The Journal of Biological Chemistry, 1952, 198: 771.
[22]	Albert WJ, Arthur EP. Arginine degradation by micrococcus pyogenes VAR. AUREUS[J]. Canadian Journal of Microbiology, 1955, 1: 339.
[23]	Roche J, Lacombe G. Sur L-arginine desiminisae et surla formation enzymatique de citrulline parles levures[J]. Biochimica et Biophysica Acta, 1952, 9: 687.[24] Chibata I, Suita S, Kakimoto T, et al. Enzymatic preparation of L-citrulline［P］. US3730838, 1973,05:01.[25] 曹瑜,李加友,焦庆才,等.酶法转化生产瓜氨酸[J].精细化工,2005,22(10):759.[26] 赵艳杰,曾倡,张淑荣,等.固定化粪链球菌酶法连续生产L-瓜氨酸[J].北京化工大学学报(自然科学版),2010,37(4):98.[27] 刘毅,尹翠,缑灵山,等.化学-生物法制备D-精氨酸和L-瓜氨酸[J].化学研究,2008,19(4):52.

Message Board

Progress on pharmacological activities and production methods of citrulline

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views