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2011 Vol. 29, No. 5

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Advances on the medication of nuclear Radiation Accidents
LIU Yu-ming, ZHANG Shu, CHU Zhi-yong
2011, 29(5): 321-323,346.
Abstract(2898) PDF (868KB)(452)
Abstract:
With the increasing competition of nuclear arms in the world and the newly emerging of nuclear technological research methods, nuclear radiation had resulted in tremendous injuries for human being. How to strengthen the emergency protection and the m...
New treatment strategies for targeted therapy of breast cancer
HUANG Jing-bin, ZHONG Yan-qiang
2011, 29(5): 324-327.
Abstract(3455) PDF (848KB)(550)
Abstract:
Common therapies of breast cancer such as chemotherapy, radiotherapy had severe systemic side effects. To reduce those side effects, developing strategies of targeted therapy was necessary. Three research fields on targeted therapy of breast cancer w...
Progress on diterpenoids gnidimacrin in Stellera chamaejasma L.
WANG Yuan-yuan, WANG Xin, WANG Yi-shan
2011, 29(5): 328-330,335.
Abstract(4085) PDF (877KB)(507)
Abstract:
A relatively complete summary on the anti-tumor component gnidimacrin was introduced, which was extracted from Stellera chamaejasma L. The research status of gnidimacrin's antitumor mechanism and its clinical application were reviewed. A further anal...
Advances in the pharmacological studies on timosaponins and their sapogenins
CAI Fei, WANG Wei-hong, GAO Shou-hong, CHEN Wan-sheng
2011, 29(5): 331-335.
Abstract(3820) PDF (861KB)(506)
Abstract:
Timosaponins and their sapogenins were the major active components from a commonly used Chinese herbal medicine, Anemarrhenae Rhizoma. Studies showed that they had a broad range of pharmacological effects such as improving senile dementia, preventing...
Advance in pharmacological effects of sirolimus
SU Feng-yun, LIU Ai-jun, SU Ding-feng
2011, 29(5): 336-338,390.
Abstract(4040) PDF (867KB)(414)
Abstract:
Sirolimus, a kind of macrolide antibiotics, was widely used in clinical as immunosuppressive agents. In recently research, it had been found that sirolimus had potent biologic activities in terms of anti-inflammatory, immunosuppression, anti-neoplasm...
Study on effective components from roots of Aconitum carmichaeli through cell membrane chromatography and HPLC-TOF/MS method
CAO Yan, JING Jing, LV Di-ya, ZHU Zhen-yu, ZHANG Guo-qing, CHAI Yi-feng
2011, 29(5): 339-341,349.
Abstract(3007) PDF (929KB)(423)
Abstract:
Objective To screen the effective components from roots of Aconitum carmichaeli by a cell membrane chromatography (CMC) combining with a HPLC-TOF/MS method. Methods Screening was conducted on a rat cardiac muscle CMC column, and mobile phase was 10 m...
Analysis of chemical constituents of Lotus leaf by HPLC-TOF/MS
ZHOU Yong-gang, LIU Chang, MAO Fei, LI Xiang
2011, 29(5): 342-346.
Abstract(3336) PDF (913KB)(375)
Abstract:
Objective To analyze chemical constituents of Lotus leaf by rapid-resolution (high performance) liquid chromatography-time of flight mass spectrometry (HPLC-TOF/MS). Methods A Agilent Zorbax SB-Aq column(250 mm×4.6mm,5μm) was used to separate. The mo...
Simultaneous determination of phenol and camphor in compound camphor liniment by HPLC
LU Song-wei, SONG Hong-jie, CHEN Fang-jian
2011, 29(5): 347-349.
Abstract(2872) PDF (866KB)(511)
Abstract:
Objective To establish a method for simultaneous determination of phenol and camphor in compound camphor liniment by HPLC. Methods The separation was performed on a Kromasil C18 analytical column(150 mm×4.6 mm, 5 μm)with the mobile phase consisting o...
Pharmacokinetics of pseudoephedrine in cetirizine sustained release tablets in human plasma
JIN Xiao-ling, GAO Shou-hong, WU Rong
2011, 29(5): 350-352,371.
Abstract(3080) PDF (929KB)(538)
Abstract:
Objective To establish a LC-MS/MS method for the determination of pseudoephedrine concentration in plasma, and to investigate the pharmacokinetics of sustained release tablets of cetirizine hydrochloride and pseudoephedrine hydrochloride in Chinese h...
Determination of sirolimus in whole blood of beagle dog by UPLC-MS/MS
CHEN Yong, LIN Chen, ZHANG Jing, QIU Bin, ZHOU Xin, SONG Hong-tao
2011, 29(5): 353-355,375.
Abstract(2842) PDF (917KB)(376)
Abstract:
Objective To develop a UPLC-MS/MS method for the determination of sirolimus in whole blood of beagle dog. Methods Sirolimus and internal standard Tacrolimus were extracted from whole blood with liquid-liquid extraction,then separated on a Agilent C18...
Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents
JIANG De-hua, LIN Jing-ming, CHEN Jian-ming, WANG Xiao-yan, LI Yuan-yuan, ZHOU Chang-jiang
2011, 29(5): 356-357,365.
Abstract(2765) PDF (918KB)(489)
Abstract:
Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by c...
1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluoroph-enyl)-3-(N-cycloproyl-N-benzyl-amino)-2-propanols
YAN Yong-zheng, CHAI Xiao-yun, ZOU Yan, YU Shi-chong, WU Qiu-ye
2011, 29(5): 358-361.
Abstract(2882) PDF (882KB)(521)
Abstract:
Objective To study the antifungal activity of triazole alcohols which introduce isopropyl as side chain. Methods By introduction of 4-carboxylic ester substituted benzyl group as side chain, a series of title compounds were synthesized. All of them w...
Synthesis and platelet aggregation inhibition activity of new derivatives of pyridazinone
WANG Shu-dong, CHEN Xing-dong, ZHAO Qing-jie, ZOU Yan, HU Hong-gang, YU Shi-chong, WANG Ting, CHAI Xiao-yun, REN Hai-xiang
2011, 29(5): 362-365.
Abstract(3644) PDF (909KB)(366)
Abstract:
Objective To study the antiplatelet aggregative activity of 6-(4-substitued acetamino-phenyl 4, 5-dihydro-3(2H)-pyridazinones with different substituted secondary amines. Methods Ten target compounds were designed and synthesized.All of them were con...
Protective effect of Shugananlening extract on acute alcohol hepatic injury in mice
XIA Ai-jun, ZHANG Qi, ZHANG Yun-bo, LIANG Yuan, TANG Zhe, ZHOU Ning-ning
2011, 29(5): 366-368.
Abstract(2686) PDF (960KB)(491)
Abstract:
Objective To study the protective effect of Shugananlening extract on acute alcoholic hepatic injury in mice. Methods The model of hepatic injury was prepared by intragastric infusion of alcohol, the change of alanine transaminase (ALT), aspartate tr...
Validation for determination method of microbacteria limit of compound Shenqi Wuwei chewable tables
HE Jin, SHI Guo-bing, GAO Jun, YANG Xiao-dong
2011, 29(5): 369-371.
Abstract(2698) PDF (844KB)(772)
Abstract:
Objective To validate the determination method of microbacteria limit of compound shenqi wuwei chewable tables. Methods Plate counting method was used.The method of counting bacteria and mould was validated by the recovery rates with 5 control trains...
Preparation and evaluation of compound Shenshe lotion
LI Yan
2011, 29(5): 372-375.
Abstract(2750) PDF (843KB)(384)
Abstract:
Objective To study the preparation method of compound Shenshe lotion. Methods The preparation method was optimized by orthogonal design and the determination method was constructed. The pharmacological effects of compound Shenshe lotion including the...
Determination of gentiopicrin in Fuzhengpingxiao capsule by HPLC-DAD
JIANG Yun-xia, ZHAN Qi, JIN Rou-nan, ZHU Zhang-chao, WANG Bin
2011, 29(5): 376-378.
Abstract(2751) PDF (861KB)(432)
Abstract:
Objective To develop a high performance liquid chromatograph method for determination of gentiopicrin in Fuzhengpingxiao capsule which could be used as a quality control indicator. Methods The separation was performed by 1100 series high performance ...
Determination of phenylethanoid glycosides in Phlomis younghusbandii by HPLC
LI Mao-xing, ZHANG Chao, WU Lan, WEI Li-li, QIN Jian-guo, ZHANG Quan-long, JIA Zheng-ping
2011, 29(5): 379-381,400.
Abstract(2514) PDF (930KB)(416)
Abstract:
Objective To establish a HPLC method for the determination of three phenylethanoid glycosides in Phlomis younghusbandii. Methods HPLC analysis was performed on Symmetry C18 (4.6 mm×150 mm, 5 μm) column and the mixture of methanol-water (36:64, pH=4.5...
Analysis of chemical drugs registered by State Food and Drug Administration in 2009
LI Wen-zhe, CHEN Hao, LI Jin-ping, FU Jun-ying, SHU Li-xin
2011, 29(5): 382-383,393.
Abstract(3184) PDF (838KB)(433)
Abstract:
Objective To investigate and analyze the distribution of chemical drugs registered by State Food and Drug Administration(SFDA) in 2009. Methods The data of registered chemical drugs in 2009 including names, approval numbers, medication classification...
Analysis of influencing factors on hospital pharmacy's productivity based-on multiple linear regression
HUO Hua, LUAN Zhi-peng, CHEN Sheng-xin
2011, 29(5): 384-386.
Abstract(3032) PDF (835KB)(411)
Abstract:
Objective To analyze the main factors affecting productivity of pharmacy, for providing a basis to improve pharmacy productivity. Method First, 61 hospital pharmacies were divided into four groups according to the numbers of beds. Then, annual per ca...
Analysis of 377 cases of perioperative antimicrobial application in our hospital
JI Min, LU Man-ting, XI Yu-ming
2011, 29(5): 387-388.
Abstract(2519) PDF (809KB)(469)
Abstract:
Objective To improve the rational application of antibiotics in the perioperative period. Methods Aaccess method and the reference method were used to evaluate the ration of antibiotics application in perioperative from 377 surgical cases in the hosp...
Discussion on the problem in the utility of electronic prescription
YANG Da-wei, XU Jian-ying, TAN Xing-hua
2011, 29(5): 389-390.
Abstract(2945) PDF (824KB)(393)
Abstract:
Objective To Optimize the process of prescribing, and ensure the legal utility of electronic prescription. Methods The process of prescribing in the People's Hospital of Shaoxing were analysis. The problems of electronic prescription in practical app...
Research on forward warehouse of military medicine supply to ensure the main medicine-supply channel
WANG Wen-sen, SUN Jie, YU Xue-zhong, YIN Xiao-fei
2011, 29(5): 391-393.
Abstract(3098) PDF (818KB)(391)
Abstract:
It was the key point to improve the medicine reserves and supply for ensuring normal medical works in hospital.And it was the new problem for military hospital to ensure the main medicine-supply channel and minimize the opportunities for medicine out...
Analysis of 107 cases of drug adverse reaction report in our hospital
WU Ting-ting, TIAN Shuo, ZUO Yan-min, GUO Jing
2011, 29(5): 394-395,397.
Abstract(2291) PDF (838KB)(378)
Abstract:
Objective To investigate the characteristics and general pattern of drug adverse reactions (ADR)occurred in our hospital. Methods A total of 107 ADR cases reported in our hospital from Apr.2009 to Mar.2010 were analyzed statistically in respect of pa...
2011, 29(5): 396-397.
Abstract(2156) PDF (811KB)(773)
Abstract:
Application of psychology in teaching of pharmacology
YAN Lan, JIANG Yuan-ying, CAO Yong-bing, WANG Yan
2011, 29(5): 398-400.
Abstract(2614) PDF (817KB)(446)
Abstract:
Pharmacology was the branch of basic medicine and clinical practice, or the branch of medicine and pharmacy, concerned with the study of drug action. The knowledge of pharmacology was difficult to understand or remember clearly because of its complic...