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SUN Di-qing, LIU Wei, SONG Shu-wei. Five-year monitoring of clinical rational drug use in our hospital[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 142-145.
Citation:
JIANG De-hua, LIN Jing-ming, CHEN Jian-ming, WANG Xiao-yan, LI Yuan-yuan, ZHOU Chang-jiang. Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 356-357,365.
Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents
Graduates Management Brigade, Second Military Medical University, Shanghai 200433, China
2.
School of Pharmacy , Second Military Medical University, Shanghai 200433, China
Received Date: 2011-03-01
Rev Recd Date:
2011-05-24
Abstract
Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by change the conditions of precipitation to precipitate crystal in ethanol-water mixed solvents. Results 4 kinds of azithromycin isample which had different DTA and XRD characteristics were acquired. Conclusions The DTA and X-ray diffraction characters of azithromycin were obtained, and conditions such as temperature and pressure could expand the research thinking of crystallization.
Ghobad M, Hadi V, Mohammad BJ, et al. Development of azithromycin-PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi[J].Colloid Surface B,2010,80:34.
[3]
Gandhi R, Pillai O, Thilagavathi R, et al. Characterization of Azithromycin hydrates[J]. Eur J Pharm Sci, 2002,16:175.
[4]
Blanco M, Valdés D, Bayod MS, et al. Characterization and analysis of polymorphs by near-infrared spectrometry[J].Anal Chim Acta,2004,502:221.
[5]
Zhang Z, Zhu YH, Yang XL, et al. Preparation of azithromycin microcapsules by a layer-by-layer self-assembly approach and release behaviors of azithromycin[J]. Colloid Surface A,2010,362:135 .
Abstract: Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by change the conditions of precipitation to precipitate crystal in ethanol-water mixed solvents. Results 4 kinds of azithromycin isample which had different DTA and XRD characteristics were acquired. Conclusions The DTA and X-ray diffraction characters of azithromycin were obtained, and conditions such as temperature and pressure could expand the research thinking of crystallization.
SUN Di-qing, LIU Wei, SONG Shu-wei. Five-year monitoring of clinical rational drug use in our hospital[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 142-145.
Citation:
JIANG De-hua, LIN Jing-ming, CHEN Jian-ming, WANG Xiao-yan, LI Yuan-yuan, ZHOU Chang-jiang. Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 356-357,365.
Ghobad M, Hadi V, Mohammad BJ, et al. Development of azithromycin-PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi[J].Colloid Surface B,2010,80:34.
[3]
Gandhi R, Pillai O, Thilagavathi R, et al. Characterization of Azithromycin hydrates[J]. Eur J Pharm Sci, 2002,16:175.
[4]
Blanco M, Valdés D, Bayod MS, et al. Characterization and analysis of polymorphs by near-infrared spectrometry[J].Anal Chim Acta,2004,502:221.
[5]
Zhang Z, Zhu YH, Yang XL, et al. Preparation of azithromycin microcapsules by a layer-by-layer self-assembly approach and release behaviors of azithromycin[J]. Colloid Surface A,2010,362:135 .
SUN Di-qing, LIU Wei, SONG Shu-wei. Five-year monitoring of clinical rational drug use in our hospital[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 142-145.
SUN Di-qing, LIU Wei, SONG Shu-wei. Five-year monitoring of clinical rational drug use in our hospital[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 142-145.
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