HE Xi-rui, LI Mao-xing, SHANG Xiao-fei, JIA Zheng-ping, ZHANG Ru-xue. Composition and anti-inflammatory activities of essential oils from Gentiana crassicaulis and Gentiana scabra[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 274-277,283.
| Citation:
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HE Xi-rui, LI Mao-xing, SHANG Xiao-fei, JIA Zheng-ping, ZHANG Ru-xue. Composition and anti-inflammatory activities of essential oils from Gentiana crassicaulis and Gentiana scabra[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 274-277,283.
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Composition and anti-inflammatory activities of essential oils from Gentiana crassicaulis and Gentiana scabra
- 1.
Lanzhou General Hospital of PLA, Lanzhou 730050,China;Lanzhou University, Lanzhou 730000,China
- 2.
Lanzhou General Hospital of PLA, Lanzhou 730050,China
- Received Date: 2010-08-31
- Rev Recd Date:
2010-11-14
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Abstract
Objective To study the anti-inflammatory activities of essential oils from the roots of G. crassicaulis Duthie ex Burkand G. scabra Bunge in vivo and in vitro. Methods The essential oils were extracted by supercritical fluid extraction (SFE), and the chemical components of the essential oils were analyzed by GC-MS. In vitro and in vivo anti-inflammatory activities of the essential oils were investigated with a cellular model of LPS-stimulated RAW264.7 cell and xylene-induced ear edema in mice. Results The essential oils were transparent and full aroma, and 29, 40 compounds were identified from G. crassicaulis and G. scabra respectively. The essential oils of G. crassicaulis and G. scabra (GCEO and GSEO) showed a good performance of inhibiting NO production and xylene-induced ear edema in mice with a dose-dependent manner. Conclusion GCEO and GSEO had excellent anti-inflammatory activities in vivo and in vitro, and thus had great potential to be further studied on the active anti-inflammatory ingredients.
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