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ZHANG Li-bin, ZHANG Xiao-qing, LI Yu-ping. Experimental study on the antidepressant activities of Isoquercitrin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 272-273,290.
Citation:
ZHANG Li-bin, ZHANG Xiao-qing, LI Yu-ping. Experimental study on the antidepressant activities of Isoquercitrin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 272-273,290.
Experimental study on the antidepressant activities of Isoquercitrin
Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China
2.
Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China;Department of Pharmacy ,The first Pepole's Hospital, Shanghai Jiaotong University ,Shanghai 200080,China
Received Date: 2010-07-21
Rev Recd Date:
2010-12-21
Abstract
Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test (FST) and the Tail Suspension Test (TST) in mice were applied to evaluate antidepressant activitie. Results Compared with the control group, low dosages(0.3 mg/kg, 3mg/kg) of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests(P<0.01). Conclusions Low dosage of Isoquercitrin showed some antidepressant activities, which was related to antioxidative effect and inhibiting of adrenocortical hormones.
Steimer W. Pharmacogenetics and Psychoactive Drug Therapy: Ready for the Patient[J]. Ther Drug Monit. 2010, Aug;32(4):381.
[2]
Xu C, Luo L, Tan RX. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model[J]. Journal of Ethnopharmacology 2004, 91: 345.
[3]
Zhang ZJ. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders[J]. Life Sciences 2004, 75:1659.
1. Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China
2. Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China;Department of Pharmacy ,The first Pepole's Hospital, Shanghai Jiaotong University ,Shanghai 200080,China
Abstract: Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test (FST) and the Tail Suspension Test (TST) in mice were applied to evaluate antidepressant activitie. Results Compared with the control group, low dosages(0.3 mg/kg, 3mg/kg) of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests(P<0.01). Conclusions Low dosage of Isoquercitrin showed some antidepressant activities, which was related to antioxidative effect and inhibiting of adrenocortical hormones.
ZHANG Li-bin, ZHANG Xiao-qing, LI Yu-ping. Experimental study on the antidepressant activities of Isoquercitrin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 272-273,290.
Citation:
ZHANG Li-bin, ZHANG Xiao-qing, LI Yu-ping. Experimental study on the antidepressant activities of Isoquercitrin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 272-273,290.
Steimer W. Pharmacogenetics and Psychoactive Drug Therapy: Ready for the Patient[J]. Ther Drug Monit. 2010, Aug;32(4):381.
[2]
Xu C, Luo L, Tan RX. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model[J]. Journal of Ethnopharmacology 2004, 91: 345.
[3]
Zhang ZJ. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders[J]. Life Sciences 2004, 75:1659.
ZHANG Li-bin, ZHANG Xiao-qing, LI Yu-ping. Experimental study on the antidepressant activities of Isoquercitrin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 272-273,290.
ZHANG Li-bin, ZHANG Xiao-qing, LI Yu-ping. Experimental study on the antidepressant activities of Isoquercitrin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 272-273,290.
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