Experimental study on the antidepressant activities of Isoquercitrin

ZHANG Li-bin; ZHANG Xiao-qing; LI Yu-ping

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test (FST) and the Tail Suspension Test (TST) in mice were applied to evaluate antidepressant activitie. Results Compared with the control group, low dosages(0.3 mg/kg, 3mg/kg) of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests(P<0.01). Conclusions Low dosage of Isoquercitrin showed some antidepressant activities, which was related to antioxidative effect and inhibiting of adrenocortical hormones.

Experimental study on the antidepressant activities of Isoquercitrin

1. Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China

2. Department of Pharmacy , ShangHai pulmonary Hospital, Tongji University , Shanghai 200433 ,China;Department of Pharmacy ,The first Pepole's Hospital, Shanghai Jiaotong University ,Shanghai 200080,China

Received Date: 2010-07-21

Rev Recd Date: 2010-12-21

Key words:

Abstract: Objective To study the antidepressant activities of Isoquercitrin on desperate rats model. Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group , Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test (FST) and the Tail Suspension Test (TST) in mice were applied to evaluate antidepressant activitie. Results Compared with the control group, low dosages(0.3 mg/kg, 3mg/kg) of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests(P<0.01). Conclusions Low dosage of Isoquercitrin showed some antidepressant activities, which was related to antioxidative effect and inhibiting of adrenocortical hormones.

HTML

Reference (10)

[1]	Steimer W. Pharmacogenetics and Psychoactive Drug Therapy: Ready for the Patient[J]. Ther Drug Monit. 2010, Aug;32(4):381.
[2]	Xu C, Luo L, Tan RX. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model[J]. Journal of Ethnopharmacology 2004, 91: 345.
[3]	Zhang ZJ. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders[J]. Life Sciences 2004, 75:1659.
[4]	俞一心,戈升荣,王桂珍. 槲皮素及其衍生物的药理作用研究进展[J].中药材,2003, 26(12): 902.
[5]	徐书云,卞如濂,陈修,等. 药理实验方法学[M].第3版.北京:人民卫生出版社,2002:226.
[6]	Doe N, Takahashi T, Kiriyama M. Behavioral despair during a water maze learning task in mice[J]. Exp Anim, 2010, 59(2):191.
[7]	Jang DP, Lee SH, Lee SY, et al. Neural responses of rats in the forced swimming test: [F-18]FDG micro PET study[J]. Behav Brain Res, 2009, 203(1):43.
[8]	Butterweck V, Jürgenliemk G, Nahrstedt A,et al. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test[J]. Planta Medica 2000, 66:3.
[9]	Butterweck V, Hegger M, Winterhoff H. Flavonoids of St. John's Wort reduce HPA axis function in the rat[J]. Planta Med,2004,70(10):1008.
[10]	黄黎明, 石鹏, 孙成荣等. 柴芪口服液抗抑郁作用实验研究[J]. 中国药师, 2009,12(1): 44.

Message Board

Experimental study on the antidepressant activities of Isoquercitrin

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views