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YAN Ying, HUANG Chen. Study on the chemical constituents of Cortex Meliae[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 285-286,317.
Citation: YAN Ying, HUANG Chen. Study on the chemical constituents of Cortex Meliae[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 285-286,317.

Study on the chemical constituents of Cortex Meliae

  • Received Date: 2011-06-03
  • Rev Recd Date: 2011-06-28
  • Objective To study the chemical constituents of Cortex Meliae. Methods Chromatographic techniques were employed to isolate and purify the chemical constituents of Cortex Meliae. Structures of the chemical constituents were elucidated by methods of IR, MS and NMR. Results Five compounds were isolated and identified as kulolactone (1), methyl kulonate (2), salanin (3), 1-tigloyltrichilinin (4) and β-sitosterol (5), respectively. Conclusion Compound 4 was a new limonoid and named as 1-tigloyltrichilinin.
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    [3] Nakatani M, Iwashita T, Mizukawa K, et al. Trichilinin, a new hexacyclic limonoid from Trichilia roka[J]. Heterocycles,1987,26(1):43.
    [4] Siddiqui S, Siddiqui BS, Ghiasuddin, et al. Tetracyclic triterpenoids of the fruit coats of Azadirachta indica[J]. Nat Prod,1991,54(2):408.
    [5] Chiang CK, Chang FC.Tetracyclic triterpenoids from Melia azedarach L.-III[J]. Tetrahedron,1973,29(14):1911.
    [6] Kraus W,Cramer R.Novel tetranortriterpenoids with insect antifeeding activity from neem oil[J]. Liebigs Ann Chem,1981,1981(1),181.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on the chemical constituents of Cortex Meliae

Abstract: Objective To study the chemical constituents of Cortex Meliae. Methods Chromatographic techniques were employed to isolate and purify the chemical constituents of Cortex Meliae. Structures of the chemical constituents were elucidated by methods of IR, MS and NMR. Results Five compounds were isolated and identified as kulolactone (1), methyl kulonate (2), salanin (3), 1-tigloyltrichilinin (4) and β-sitosterol (5), respectively. Conclusion Compound 4 was a new limonoid and named as 1-tigloyltrichilinin.

YAN Ying, HUANG Chen. Study on the chemical constituents of Cortex Meliae[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 285-286,317.
Citation: YAN Ying, HUANG Chen. Study on the chemical constituents of Cortex Meliae[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 285-286,317.
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