孟鲁司特钠水溶液的胶束性质研究

鄢寒; 黄月英; 沈一唯; 石晓晴; 卞俊

doi:10.3969/j.issn.1006-0111.2017.01.009

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

《药学实践与服务》杂志目前不收取审稿费、版面费、加急费等费用，如收到邮件声称是编辑部X编辑，要求加作者微信的，请谨防财产损失！编辑部用于作者校对时绑定微信的邮件通过yxsjzzs@163.com发送，标题是《药学实践与服务》XML数字出版服务微信绑定，请区分开。

孟鲁司特钠水溶液的胶束性质研究

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊

文章导航 > 药学实践与服务 > 2017 > 35(1): 36-38,66

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

引用本文:

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

Citation:

YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

孟鲁司特钠水溶液的胶束性质研究

doi: 10.3969/j.issn.1006-0111.2017.01.009

1.
解放军411医院药学科, 上海 200434;江西中医药大学药学院, 江西南昌 330004
2.
解放军411医院药学科, 上海 200434

Study on the micelle properties of montelukast sodium in aqueous solution

1.
Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2.
Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China

摘要: 目的研究具有表面活性的药物孟鲁司特钠的水溶液性质，为其开发成胶束及其相关制剂提供实验依据。方法用电导法测定孟鲁司特钠的临界胶束浓度（critical micelle concentration， CMC）并考察温度对CMC的影响；用紫外-可见光分光光度法测定不同浓度孟鲁司特钠水溶液的透光率，并考察加入不同浓度氯化钠对吸光度和透光率的影响；高速离心法考察孟鲁司特钠水溶液形成胶束后的稳定性。结果孟鲁司特钠在25℃、30℃、35℃的CMC分别为0.75、0.82、0.90 mmol/L；氯化钠对孟鲁司特钠水溶液吸光度和透光率的影响不仅与氯化钠的浓度有关，还与孟鲁司特钠溶液的自身浓度有关；当孟鲁司特钠水溶液浓度>7.5 mmol/L时可得到澄清溶液且高速离心无沉淀。结论孟鲁司特钠为具有表面活性作用的药物，其水溶液的胶束性质易受温度和电解质的影响，可利用此性质将其开发为胶束或混合胶束制剂。
- 孟鲁司特钠 /
- 表面活性 /
- 临界胶束浓度 /
- 吸光度 /
- 透光率 /
- 稳定性
Abstract: Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements. The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels. The micelle stability was evaluated via high speed centrifugal. Results The CMC of MS aqueous solution at 25℃, 30℃, 35℃ were 0.75, 0.82, 0.90 mmol/L. The absorbance and transmittance of MS aqueous solution were affected by the sodium chloride concentration and the concentration of MS itself. It was observed that a clear solution was obtained when MS concentration >7.5 mmol/L and no precipitation was noticed even after high speed centrifugal. Conclusion Montelukast sodium is a surface active drug. Its solubility is related to MS concentration. The solubility is also sensitive to the temperature and the electrolyte concentration. These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical preparations.
- montelukast sodium /
- surface active /
- CMC /
- absorbance /
- transmittance /
- stability

[1]	李国胜, 王海燕, 杨红娟.孟鲁司特钠片的循证应用[J].山西医药杂志, 2016, 45(10):1174-1178.
[2]	Kabir-Ud-Din, Al-Ahmadi MD, Naqvi AZ, et al. Conductometric study of antidepressant drug-cationic surfactant mixed micelles in aqueous solution[J]. Colloids Surf B:Biointerfaces, 2008, 64(1):65-69.
[3]	韩丽梅, 王卓, 邓英杰,等.用透光率评价分散片混悬性的方法[J].药物分析杂志, 1996,16(6):396-397.
[4]	赵国玺.表面活性剂物理化学[M]. 北京:北京大学出版社, 1991:190-192.
[5]	Attwood DT.Surfactant Systems Their Chemistry, Pharmacy and Biology[M]. London:Chapman & Hall,1983:72-117.
[6]	Causon D, Gettins J, Gormally J, et al.Ultrasonic relaxations associated with aggregation in drugs[J]. J Chem Soc Faraday Trans, 1981, 77(1):143-151.

[1]	魏莱, 董国强, 盛春泉. 靶向SARS-CoV-2主蛋白酶的PROTAC设计、合成与蛋白降解活性研究 . 药学实践与服务, 2025, 43(5): 1-8. doi: 10.12206/j.issn.2097-2024.202503063
[2]	吴若南, 叶爽, 李墨晨轩, 缪震元, 罗川. 冬凌草甲素磺酰脲衍生物的设计与抗炎活性的研究 . 药学实践与服务, 2025, 43(): 1-5. doi: 10.12206/j.issn.2097-2024.202401048
[3]	施乔, 韩贵焱, 张俊腾, 刘娜. 新型Hsp90抑制剂的设计合成及其抗真菌和抗肿瘤活性研究 . 药学实践与服务, 2025, 43(3): 124-135. doi: 10.12206/j.issn.2097-2024.202501019
[4]	李惠萍, 陈璐, 张琪金, 黄宝康. 紫苏叶挥发油成分的生物合成、含量测定及生物活性研究进展 . 药学实践与服务, 2025, 43(): 1-6. doi: 10.12206/j.issn.2097-2024.202412058
[5]	杨秋娅, 刘夏. 苯扎贝特致横纹肌溶解文献病例分析 . 药学实践与服务, 2025, 43(): 1-7. doi: 10.12206/j.issn.2097-2024.202404081
[6]	关欣怡, 杨宇洁, 闻俊. 不同场景下芬太尼类新精神活性物质检测研究进展 . 药学实践与服务, 2025, 43(): 1-7. doi: 10.12206/j.issn.2097-2024.202308033
[7]	卢熠菲, 宋佳, 沈红霞, 赵庆杰. 新型苦参碱衍生物的设计合成与体外抗炎活性研究 . 药学实践与服务, 2025, 43(): 1-8. doi: 10.12206/j.issn.2097-2024.202503005
[8]	吴若南, 汤文敏, 高林, 吴岳林, 罗川, 缪震元. RRx-001衍生物的合成和抗肿瘤活性研究 . 药学实践与服务, 2025, 43(): 1-5. doi: 10.12206/j.issn.2097-2024.202408053
[9]	张紫璇, 高苑, 张利, 李佳莉, 徐希科, 祖先鹏. 中药防治急性肺损伤的活性成分及其作用机制研究进展 . 药学实践与服务, 2025, 43(): 1-7. doi: 10.12206/j.issn.2097-2024.202404079
[10]	崔亚玲, 吴琼, 马良煜, 胡北, 姚东, 许子华. 肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯皮肤药动学研究 . 药学实践与服务, 2025, 43(1): 6-9, 21. doi: 10.12206/j.issn.2097-2024.202404006
[11]	詹济华, 颜滢. 低蛋白血症对头孢哌酮血药浓度的影响 . 药学实践与服务, 2025, 43(): 1-5. doi: 10.12206/j.issn.2097-2024.202309040
[12]	王晓飞, 张颖, 顾佳钰, 胡馨儿, 张海, 曹岩. 表面等离子共振传感器的识别元件在医药领域中的研究应用进展 . 药学实践与服务, 2025, 43(5): 1-9. doi: 10.12206/j.issn.2097-2024.202309014
[13]	姚小静, 计佩影, 陆峰, 施国荣, 傅翔. 表面增强拉曼光谱法快速测定尿液中曲马多的研究 . 药学实践与服务, 2025, 43(4): 185-189. doi: 10.12206/j.issn.2097-2024.202401072
[14]	白学鑫, 陈玉平, 盛春泉, 武善超. 具核梭杆菌小分子抑制剂的筛选及其抗结直肠癌活性研究 . 药学实践与服务, 2024, 42(12): 503-507. doi: 10.12206/j.issn.2097-2024.202405009
[15]	桂明珠, 李静, 李志玲. 儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020
[16]	丁千雪, 尚圣兰, 余梦辰, 余爱荣. 机器学习在肾病综合征患者他克莫司个体化用药中的应用 . 药学实践与服务, 2024, 42(6): 227-230, 243. doi: 10.12206/j.issn.2097-2024.202310007
[17]	赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量. 中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
[18]	凯丽比努尔·奥布力艾散, 李倩, 谢志, 贾文彦, 尹东锋. 星点设计-效应面法优化仑伐替尼混合胶束的制备工艺 . 药学实践与服务, 2024, 42(11): 495-502. doi: 10.12206/j.issn.2097-2024.202403019
[19]	史生辉, 石飞, 雷琼, 王亚峰, 吴雪花. 青藏高原肺结核合并念珠菌感染患者的病原菌分布特点及耐药率分析 . 药学实践与服务, 2024, 42(6): 260-262, 272. doi: 10.12206/j.issn.2097-2024.202304014
[20]	陈春娟, 郑志新, 李骊. 平喘方联合孟鲁司特钠治疗儿童支气管哮喘的临床疗效观察 . 药学实践与服务, 2024, 42(12): 524-527, 532. doi: 10.12206/j.issn.2097-2024.202405035

点击查看大图

计量

文章访问数: 3561
HTML全文浏览量: 361
PDF下载量: 842
被引次数: 0

孟鲁司特钠水溶液的胶束性质研究

doi: 10.3969/j.issn.1006-0111.2017.01.009

1. 解放军411医院药学科, 上海 200434;江西中医药大学药学院, 江西南昌 330004

2. 解放军411医院药学科, 上海 200434

收稿日期: 2016-07-30
修回日期: 2016-11-13

关键词:

孟鲁司特钠 /

表面活性 /

临界胶束浓度 /

吸光度 /

透光率 /

稳定性

摘要: 目的研究具有表面活性的药物孟鲁司特钠的水溶液性质，为其开发成胶束及其相关制剂提供实验依据。方法用电导法测定孟鲁司特钠的临界胶束浓度（critical micelle concentration， CMC）并考察温度对CMC的影响；用紫外-可见光分光光度法测定不同浓度孟鲁司特钠水溶液的透光率，并考察加入不同浓度氯化钠对吸光度和透光率的影响；高速离心法考察孟鲁司特钠水溶液形成胶束后的稳定性。结果孟鲁司特钠在25℃、30℃、35℃的CMC分别为0.75、0.82、0.90 mmol/L；氯化钠对孟鲁司特钠水溶液吸光度和透光率的影响不仅与氯化钠的浓度有关，还与孟鲁司特钠溶液的自身浓度有关；当孟鲁司特钠水溶液浓度>7.5 mmol/L时可得到澄清溶液且高速离心无沉淀。结论孟鲁司特钠为具有表面活性作用的药物，其水溶液的胶束性质易受温度和电解质的影响，可利用此性质将其开发为胶束或混合胶束制剂。

English Abstract

Study on the micelle properties of montelukast sodium in aqueous solution

1. Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

2. Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China

Received Date: 2016-07-30
Rev Recd Date: 2016-11-13

Keywords:

Abstract: Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements. The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels. The micelle stability was evaluated via high speed centrifugal. Results The CMC of MS aqueous solution at 25℃, 30℃, 35℃ were 0.75, 0.82, 0.90 mmol/L. The absorbance and transmittance of MS aqueous solution were affected by the sodium chloride concentration and the concentration of MS itself. It was observed that a clear solution was obtained when MS concentration >7.5 mmol/L and no precipitation was noticed even after high speed centrifugal. Conclusion Montelukast sodium is a surface active drug. Its solubility is related to MS concentration. The solubility is also sensitive to the temperature and the electrolyte concentration. These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical preparations.

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

引用本文:

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

Citation: