西沙群岛隋氏蒂壳海绵<i>Theonella swinhoei</i>的化学成分研究

李彦赟; 徐彬; 程春伟; 林厚文; 杨帆

doi:10.3969/j.issn.1006-0111.2018.01.011

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西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究

李彦赟, 徐彬, 程春伟, 林厚文, 杨帆

文章导航 > 药学实践与服务 > 2018 > 36(1): 55-60

李彦赟, 徐彬, 程春伟, 林厚文, 杨帆. 西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究[J]. 药学实践与服务, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011

引用本文:

李彦赟, 徐彬, 程春伟, 林厚文, 杨帆. 西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究[J]. 药学实践与服务, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011

LI Yanyun, XU Bin, CHENG Chunwei, LIN Houwen, YANG Fan. Chemical constituents from the marine sponge Theonella swinhoei[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011

Citation:

LI Yanyun, XU Bin, CHENG Chunwei, LIN Houwen, YANG Fan. Chemical constituents from the marine sponge Theonella swinhoei[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011

西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究

doi: 10.3969/j.issn.1006-0111.2018.01.011

上海交通大学医学院附属仁济医院药学部, 上海 200127

基金项目: 国家自然科学基金项目（U1605221，41476121，81602981）

Chemical constituents from the marine sponge Theonella swinhoei

Department of Pharmacy, Renji Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

摘要: 目的对采自西沙群岛的隋氏蒂壳海绵（Theonella swinhoei）的次生代谢产物进行研究。方法运用溶剂分步萃取以及减压柱色谱、中压柱色谱、薄层色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱及液质联用等多种色谱分离与分析手段，对隋氏蒂壳海绵的石油醚和二氯甲烷萃取部位进行分离纯化，通过化合物的理化性质及波谱数据，结合文献进行结构鉴定。结果共分离得到8个化合物，分别鉴定为cholest-7-ene-3β，5α，6β-triol（ 1 ），ergosta-7，22-diene-3β，5α，6β-triol（ 2 ），25-norcycloartane-3β，6α，16β，24-tetraol（ 3 ），sinuflexibilin D（ 4 ），14-deoxycrassin（ 5 ），N-（2-phenylethyl）-（9Z）-tetradecanamide（ 6 ），N-（2-phenylethyl）-tetradecanamide（ 7 ），7，8-dimethyl-isoalloxazine（ 8 ）。结论化合物 1 ~ 7 首次从Theonella属海绵中分离得到。
- 隋氏蒂壳海绵 /
- 化学成分 /
- 结构鉴定
Abstract: Objective To investigate the chemical constituents of the marine sponge Theonella swinhoei collected from the Xisha Islands in the South China Sea. Methods The petroleum ether and dichloromethane extract of the marine sponge T. swinhoei were purified by solvent extraction and chromatographic methods including vacuum liquid chromatography(VLC), medium pressure liquid chromatography(MPLC), thin layer chromatography(TLC) on silica gel, high performance liquid chromatography(HPLC), and Sephadex LH-20. The chemical structures were determined by spectroscopic analysis and comparison with the reported data. Results Eight compounds were isolated and their structures were determined as cholest-7-ene-3β,5α,6β-triol ( 1 ), ergosta-7,22-diene-3β,5α,6β-triol ( 2 ), 25-norcycloartane-3β,6α,16β,24-tetraol ( 3 ), sinuflexibilin D ( 4 ), 14-deoxycrassin ( 5 ), N-(2-phenylethyl)-(9Z)-tetradecanamide( 6 ), N-(2-phenylethyl)-tetradecanamide ( 7 ), 7,8-dimethyl-isoalloxazine ( 8 ). Conclusion Compounds 1 ~ 7 were isolated from the sponge of genus Theonella for the first time.
- Theonella swinhoei /
- marine sponge /
- chemical constituents

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西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究

doi: 10.3969/j.issn.1006-0111.2018.01.011

上海交通大学医学院附属仁济医院药学部, 上海 200127

基金项目: 国家自然科学基金项目（U1605221，41476121，81602981）

收稿日期: 2017-04-06
修回日期: 2017-09-12

关键词:

隋氏蒂壳海绵 /

化学成分 /

结构鉴定

摘要: 目的对采自西沙群岛的隋氏蒂壳海绵（Theonella swinhoei）的次生代谢产物进行研究。方法运用溶剂分步萃取以及减压柱色谱、中压柱色谱、薄层色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱及液质联用等多种色谱分离与分析手段，对隋氏蒂壳海绵的石油醚和二氯甲烷萃取部位进行分离纯化，通过化合物的理化性质及波谱数据，结合文献进行结构鉴定。结果共分离得到8个化合物，分别鉴定为cholest-7-ene-3β，5α，6β-triol（ 1 ），ergosta-7，22-diene-3β，5α，6β-triol（ 2 ），25-norcycloartane-3β，6α，16β，24-tetraol（ 3 ），sinuflexibilin D（ 4 ），14-deoxycrassin（ 5 ），N-（2-phenylethyl）-（9Z）-tetradecanamide（ 6 ），N-（2-phenylethyl）-tetradecanamide（ 7 ），7，8-dimethyl-isoalloxazine（ 8 ）。结论化合物 1 ~ 7 首次从Theonella属海绵中分离得到。