HPLC法测定头孢曲松含量的不确定度评估
Evaluation of measurement uncertainty method for determination of Ceftriaxone by HPLC
-
摘要: 目的 对高效液相色谱法(HPLC)测定头孢曲松含量的测量不确定度进行评估。 方法 采用HPLC法测定头孢曲松的含量,建立数学模型,分析不确定度来源。 结果 通过对各变量的分析,计算各变量的不确定度,最后计算出合成标准不确定度。 结论 本方法建立的数学模型合理、可靠。Abstract: Objective To evaluate the uncertainty of measurement for determination of Ceftriaxone by HPLC. Methods The content of Ceftriaxone was determined by HPLC .The mathematical model was established to analyze the source of uncertaint. Results Every component of uncertainty was evaluated through the variable parameters among the procedures . The combined standard uncertainty was finally obtained by synthesizing the uncertainties of all variables. Conclusion The statistical approach of measurement uncertainty established in this paper was reasonable and reliable.
-
Key words:
- HPLC /
- Ceftriaxone /
- measurement uncertainty
-
[1] 国家质量技术监督局. JJF1059-1999,测量不确定度评定与表示[S].北京:中国计量出版社,1999. [2] 王立云,卢京光,HPLC法测定头孢硫脒含量的不确定度分析[J].齐鲁药事,2007,26,(4):217. [3] 陈汝红, 杨 梁,HPLC 法测定头孢羟氨苄含量的不确定度评估[J].中国药事,2007,21(7):488. [4] 陈 星,费休氏法测定注射用头孢曲松钠水分的不确定度评定[J].海峡药学,2010,22(12):63. [5] 王洪家,马 兰,贾志刚. 注射用头孢曲松钠含量测定的不确定度分析[J].天津药学,2010,22(1):24. [6] 申 安,HPLC法测定头孢氨苄胶囊含量的测量不确定度评定[J]. 药物分析杂志,2009,29(8):1384. [7] 中国药典2010版.二部[S]. 2010:181. -
点击查看大图
计量
- 文章访问数: 2212
- HTML全文浏览量: 196
- PDF下载量: 361
- 被引次数: 0
下载:
