正交实验法优选复方水牛角颗粒提取工艺的研究
Optimization of extraction process of compound Shuiniujiao granule by orthogonal test
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摘要: 目的: 选择复方水牛角颗粒制剂的最佳提取工艺。 方法: 对提取溶剂、加水量、提取次数及提取时间作为考察因素,采用正交设计法每个因素拟订3个水平,并用相应的药效学实验结果评价每一种工艺的药效作用的优劣,再结合得率和实际生产选择最佳工艺。 结果: 用8倍量50%乙醇提取3次、每次1 h,此工艺所得的复方水牛角颗粒制剂的得率和药效学结果最佳。 结论: 采用正交设计和相应的药效学实验的结果优选提取工艺是一个合理的和值得提倡的方法。Abstract: Objective To select the best extraction process in preparation of compound Shuiniujiao granule. Methods The extraction solvent,add water,extraction times and extraction time as the study factors,each factor orthogonal design method developed three horizontal,and use the Results of the corresponding pharmacodynamic evaluation of the efficacy of each role in a process,combined with the yield and the actual production process to select the best. Results 50% ethanol,plus 8 times the amount of extracted three times,each time a small process when the compound derived from buffalo horn grain yield of preparation and pharmacodynamics of the most satisfactory Results. Conclusion Orthogonal design and the corresponding pharmacodynamic Results of the experiment to select the extraction process is a reasonable approach should be advocated.
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Key words:
- extraction process /
- orthogonal test /
- pharmacodynamic experiment
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