以玻璃酸钠为媒介对氯霉素在滴眼液中释放的影响
Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops
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摘要: 目的: 研究以玻璃酸钠为媒介对氯霉素在滴眼液中释放的影响因素。 方法: 配制各影响因素不同的氯霉素溶液,采用改良的Franz扩散池,测定药物的渗透速率。 结果: 增加溶液的黏度能减慢氯霉素的释放速率,其释放速率随着玻璃酸钠浓度的增加而降低,随着氯霉素浓度的增加而提高。 结论: 氯霉素在滴眼液中的释放速率与溶液的黏度和药物浓度有关,但通过增加溶液黏度使药物达到缓释的方法是有限度的。Abstract: Objective: To study the influence factores of chloramphenicol release with sodium hyaluronate as vehicle in eye drops. Methods: The penetration rates of chloramphenicol were determined with modified Franz diffusion cell in solutions with different influ-ence factores. Results: The increase of solution viscosity could decrease the release rate of chloramphenicol.The release rates of chlor-amphenicol decreased with the concentrations of sodium hyaluronate increased and increased with the concentrations of chloramphenicol increased. Conclusion: The release rate of chloramphenicol in eye drops is concerned with viscosity of solution and drug concentration, but there is a limite to the drug sustained release by increasing viscosity of solution.
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Key words:
- solution hyaluronate /
- chloramphenicol /
- drug release
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