复方醋酸地塞米松搽剂的含量测定
Determination of compound dexamethason acetate liniment
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摘要: 目的 建立复方醋酸地塞米松搽剂中樟脑和醋酸地塞米松的含量测定方法.方法 采用一阶导数光谱法于(305±1)nm波长处直接测定樟脑的含量;采用可见分光光度法于(485±1)nm波长处测定醋酸地塞米松的含量.结果 樟脑含量在1.62～3.22mg/mL浓度范围内,线性关系良好,相关系数r=0.999 4,平均回收率99.89%,RSD为0.34%.醋酸地塞米松含量在122.04～227.81μg/mL浓度范围内,线性关系良好,相关系数r=0.999 7,平均回收率99.18%,RSD为1.2%.结论 本方法简便、快速、准确,可用于复方醋酸地塞米松搽剂的质量控制.Abstract: Objective To establish a quantitative analysis method for camphor and dexamethason acetate in compound dexametha son acetate liniment.Methods The camphor was determined directly at 305nm by first derivative spectrometry.The dexamethason acetate was determined at 485nm by seeable spectrometry.Results The calibra-tion curve of camphor was linear in the range from 1.62-3.22mg/mL with r=0.999 4,the average recovery and relative standard deviation were 99.89% and 0.34% respectively.The calibration curve of dexamethason acetate was linear in the range from 122.04-227.81μg/mL with r= 0.9997, the average recovery and RSD were 99.18% and 1.32% respectively.Conclusions The method is simple, rapid and accurate.It can be used to control the quality of compound dexame-thason acetate liniment.
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