群体药动学应用于个体化给药的研究进展

林艳

doi:10.3969/j.issn.1006-0111.2015.04.002

群体药动学应用于个体化给药的研究进展

doi: 10.3969/j.issn.1006-0111.2015.04.002

林艳

同济大学附属杨浦医院药剂科, 上海 200433

Research progress of population pharmacokinetics applying to individualized medication

LIN Yan

Department of Pharmacy, Yangpu Hospital affiliated to Tongji University, Shanghai 200433, China

摘要: 群体药动学运用经典的药动学原理结合统计学方法,以稀疏数据预测患者血药浓度,可达到监测药物体内过程和指导临床个性化给药的目的。查阅近年来的相关文献,结合实例综述群体药动学应用于治疗窗窄的药物、个体差异大的药物、联合用药、特殊人群用药等方面的最新进展,为其深入研究和指导临床用药提供参考。
- 群体药动学 /
- 个体化给药 /
- 非线性混合效应模型 /
- Bayesian反馈法
Abstract: Combining the classic pharmacokinetic principles and statistical methods, population pharmacokinetics (PPK) can predict individual pharmacokinetic parameters accurately with sparse data in patients, which may be used for monitoring drug concentration in patients and realizing individual dose regimen. In this article, we review the recent application of PPK in drugs with narrow therapeutic windows or great individual differences, combining medication, medication in special populations and so on, providing useful information for further investigation of PPK and its application in clinical medication.
- population pharmacokinetics /
- individual dose regimen /
- nonlinear mixed effect model /
- Bayesian forecasting

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群体药动学应用于个体化给药的研究进展

doi: 10.3969/j.issn.1006-0111.2015.04.002

Research progress of population pharmacokinetics applying to individualized medication

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群体药动学应用于个体化给药的研究进展

doi: 10.3969/j.issn.1006-0111.2015.04.002

同济大学附属杨浦医院药剂科, 上海 200433

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Research progress of population pharmacokinetics applying to individualized medication

Department of Pharmacy, Yangpu Hospital affiliated to Tongji University, Shanghai 200433, China

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群体药动学应用于个体化给药的研究进展

doi: 10.3969/j.issn.1006-0111.2015.04.002

Research progress of population pharmacokinetics applying to individualized medication

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群体药动学应用于个体化给药的研究进展

doi: 10.3969/j.issn.1006-0111.2015.04.002

同济大学附属杨浦医院药剂科, 上海 200433

English Abstract

Research progress of population pharmacokinetics applying to individualized medication

Department of Pharmacy, Yangpu Hospital affiliated to Tongji University, Shanghai 200433, China

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