聚乙烯醇衍生物作为水凝胶材料的应用研究进展

胡晓; 胡容峰; 白中稳

doi:10.3969/j.issn.1006-0111.2013.03.002

聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

安徽中医学院, 安徽合肥 230031

Applied research of polyvinyl alcohol derivatives as hydrogel materials

Anhui University of Traditional Chinese Medicine, Hefei 230031, China

摘要: 目的介绍PVA衍生物作为水凝胶材料的应用研究进展,为进一步开发它提供依据和参考。方法参阅近年来国内外相关文献资料,对其进行综合、分析和归纳。结果 PVA水凝胶具有亲水性、柔软性、温和性和良好的生物相容性,其衍生物作为普通水凝胶和智能水凝胶材料被广泛应用于生物医药学领域。结论 PVA是一种极具再次开发潜力的优良药用辅料,具有很大的应用价值。
- 聚乙烯醇 /
- 衍生物 /
- 水凝胶 /
- 应用进展
Abstract: Objective To introduce the application research progress of PVA derivatives as hydrogel materials, and provide the basis and reference for further development. Methods The related documents at home and abroad in recent years were integrated, analyzed and summarized. Results PVA derivatives as conventional and sensitive hydrogel materials were widely used in the fields of biomedicine, having a hydrophilic, softness, mild characteristics and good biocompatibility. Conclusion PVA is an excellent pharmaceutical excipient for potential re-development, and having a great value.
- polyvinyl alcohol /
- derivatives /
- hydrogel /
- application progress

[1]	Sailaja GS,Sreenivasan K,Yokogawa Y,et al.Bioinspired mineralization andcell adhesion on surface functionalized PVA films[J].Acta Biomater,2009,5(5):1647.
[2]	Singh B,Sharma V.Design of psyllium-PVA-acrylic acid based novel hydrogels for use in antibiotic drug delivery[J].Int J Pharm,2010,389:94.
[3]	AL-Sabagh AM, Abdeen Z. Preparation and characterization of hydrogel based on PVA cross-linked by different cross-linkers used to dry organic solvents[J]. J Polym Environ,2010,18:576.
[4]	Otsuka E, Sugiyama M, Suzuki A. Formation and destruction of physical crosslinks by mild treatments in chemically crosslinked PVA gels[J].Polym Bull,2010,10:1007.
[5]	Wang JQ, Satoh M. Water properties in a novel thermoswelling PVA derivative hydrogel as studied by NMR and FTIR[J]. Langmuir, 2010, 26(16):13607.
[6]	Padavan DT,Hamilton AM,Millon LE,et al.Synthesis, characterization and in vitro cell compatibility study of a PAA graft/cross-linked PVA hydrogel[J]. ActaBiomaterialia,2011,7:258.
[7]	Alves MH,Young CJ,Bozzetto K,et al.Degradable,click PVA hydrogels:characterization of degradation and cellular compatibility[J]. Biomed Mater,2011,7:1.
[8]	Artyukhov AA,Shtilman MI,Kuskov AN,et al.Macroporous polymeric hydrogels formed from acrylate modified PVA macromers[J].Eur Polym J,2011,10(18):667.
[9]	Pan YS,Xiong DS,Gao F.Viscoelastic behavior of no-HA reinforced PVA gel biocomposites as an articular cartilage[J].J Mater Sci,2008,19:1963.
[10]	Cho SH,Lim SM,Han DK,et al.Time-dependent alginate/PVA hydrogels as injectable cell carriers[J].JBiomat Sci-Polym E,2009,20:863.
[11]	Negishi J,Nam KW,Kimura TS,et al.High-hydrostatic pressure technique is an effective method for the preparation of PVA-heparin hybridgel[J].Eur J Pharm Sci,2010,41:617.
[12]	Zan XJ,Kozlov M,McCarthy TJ,et al.Covalently attached, silver-doped PVA hydrogel films on Poly(L-lactic acid)[J].Biomacromolecules,2010,11:1082.
[13]	Abitbol T,Johnstone T,Quinn TM,et al.Reinforcement with cellulose nanocrystals of PVA hydrogels prepared by cyclic freezing and thawing[J].Soft Matter,2011,7:2373.
[14]	Bakhshandeh H,Soleimani M,Hosseini SS,et al.Poly (ε-caprolactone) nanofibrous ring surrounding a PVA hydrogel for the development of a biocompatible two-part artificial cornea[J].Int J Nanomed,2011,6:1509.
[15]	Sukhanova TV,Artyukhov AA,Prudchenko IA,et al.Entrapment and in vitro release of delta-sleep inducing peptide from polymer hydrogels based on modified PVA[J]. Biomedical Chemistry, 2012, 6(2):149.
[16]	姚女兆.果胶/PVA复合水凝胶人工髓核的实验研究[D].南方医科大学,2010.
[17]	Aboutaleb MF,Ismail SA,El-kelesh NA.Radiation synthesis and characterization of PVA/MAA-GEL hydrogel for vitro drug delivery[J].J Macromol Sci B,2009,46:170.
[18]	Wang B,Liu MZ,Chen ZB,et al.Preparation, characterization and controlled release investigation of interpenetrating polymer networks of PAA/triazole modified PVA[J].Int J Pharm,2007,331:19.
[19]	祝宝东,孟静,王鉴,等. PVA/淀粉接枝P(AA-AM)互穿网络水凝胶的合成与性能研究[J].科学技术与工程, 2011, 11(10):2234.
[20]	Qi BW,Yu AX,Zhu SB,et al.The preparation and cytocompatibility of injectable thermosensitive CS/PVA hydrogel[J].Med Sci,2010,30(1):89.
[21]	Tang YF,Du YM,Li Y,et al.A thermosensitive CS/PVA hydrogel containing hydroxyapatite for protein delivery[J].J Biomed Mater Res A, 2009, 91(4):953.
[22]	陈丽如. CS/PVA温敏性水凝胶给药系统的研究[D].河北大学,2011.
[23]	史林峰.PVA/AM接枝共聚物水凝胶的制备及表征[J].中国组织工程研究,2012,16(21):3919.
[24]	Zhang NY,Shen YG,Li XQ,et al.Synthesis and characterization of thermoand pH-sensitive PVA/poly(N,N-diethylacrylamide-co-itaconic acid) semi-IPN hydrogels[J].Biomed Mater,2012,7:1.

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聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

Applied research of polyvinyl alcohol derivatives as hydrogel materials

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聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

安徽中医学院, 安徽合肥 230031

English Abstract

Applied research of polyvinyl alcohol derivatives as hydrogel materials

Anhui University of Traditional Chinese Medicine, Hefei 230031, China

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聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

Applied research of polyvinyl alcohol derivatives as hydrogel materials

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聚乙烯醇衍生物作为水凝胶材料的应用研究进展

doi: 10.3969/j.issn.1006-0111.2013.03.002

安徽中医学院, 安徽 合肥 230031

English Abstract

Applied research of polyvinyl alcohol derivatives as hydrogel materials

Anhui University of Traditional Chinese Medicine, Hefei 230031, China

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安徽中医学院, 安徽合肥 230031