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长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

丁佳宁,  马进原,  朱全刚

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文章导航 > 药学实践与服务  > 2019 >  37(5): 390-393,421
丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu

长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
  • 1.

    上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437

  • 2.

    上海市皮肤病医院药剂科, 上海 200443

  • 3.

    上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443

基金项目: 国家自然科学基金（81472394）；上海市皮肤病医院国家自然科学基金培育项目（17GZRPY11）

Research progress of lncRNA MEG3 in tumorigenesis

  • 1.

    Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

  • 2.

    Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 3.

    Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 摘要: 长链非编码RNA（long non-coding RNA，lncRNA）覆盖了人类DNA的大部分非编码信息，占整个基因组的90%以上，它们构成了一个广泛而复杂的分子群，在肿瘤的病理生理过程中以多种形式存在。2003年，lncRNA人母系表达基因（MEG）3被证明是垂体瘤的一个潜在的肿瘤抑制因子，之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤，以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究，发现MEG3在多种恶性肿瘤组织中低表达或表达缺失，而上调MEG3的表达与肿瘤生长抑制相关，其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。
    Abstract: Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the course of pathophysiology of cancers.In 2003,lncRNA MEG3 was firstly discovered as a potential tumor-inhibiting factor of pituitary adenomas.Later on,the roles and mechanisms in the regulation of gene expression,imprinting,transcription,and post-translation of MEG3 in meningioma,hepatocellular cancer,lung cancer,neuroendocrine tumor,prostate cancer and other kinds of tumors were further clarified,indicated that the expression of MEG3 was down-regulated or deficient in a wide range of tumors while the expression up-regulation of MEG was greatly correlated with tumor inhibition.The function of MEG3 and its research progress in tumorigenesis were summarized in this paper.
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长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
  • 1. 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437
  • 2. 上海市皮肤病医院药剂科, 上海 200443
  • 3. 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443
    • 基金项目:  国家自然科学基金（81472394）；上海市皮肤病医院国家自然科学基金培育项目（17GZRPY11）
  • 收稿日期: 2019-04-04
  • 修回日期: 2019-06-11

摘要: 长链非编码RNA（long non-coding RNA，lncRNA）覆盖了人类DNA的大部分非编码信息，占整个基因组的90%以上，它们构成了一个广泛而复杂的分子群，在肿瘤的病理生理过程中以多种形式存在。2003年，lncRNA人母系表达基因（MEG）3被证明是垂体瘤的一个潜在的肿瘤抑制因子，之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤，以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究，发现MEG3在多种恶性肿瘤组织中低表达或表达缺失，而上调MEG3的表达与肿瘤生长抑制相关，其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。

English Abstract

丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu

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