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补肾阳与补肾阴中药抗骨质疏松作用的研究进展

夏天爽,  薛黎明,  张巧艳,  辛海量,  李睿旻,  秦路平

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文章导航 > 药学实践与服务  > 2019 >  37(2): 109-114,155
夏天爽, 薛黎明, 张巧艳, 辛海量, 李睿旻, 秦路平. 补肾阳与补肾阴中药抗骨质疏松作用的研究进展[J]. 药学实践与服务, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
引用本文: 夏天爽, 薛黎明, 张巧艳, 辛海量, 李睿旻, 秦路平. 补肾阳与补肾阴中药抗骨质疏松作用的研究进展[J]. 药学实践与服务, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
shu
XIA Tianshuang, XUE Liming, ZHANG Qiaoyan, XIN Hailiang, LI Ruimin, QIN Luping. Research progress in anti-osteoporosis effects of the herbs tonifying kidney-yang and kidney-yin[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
Citation: XIA Tianshuang, XUE Liming, ZHANG Qiaoyan, XIN Hailiang, LI Ruimin, QIN Luping. Research progress in anti-osteoporosis effects of the herbs tonifying kidney-yang and kidney-yin[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
shu

补肾阳与补肾阴中药抗骨质疏松作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.02.003
  • 1.

    海军军医大学药学院, 上海 200433

  • 2.

    上海市疾病预防中心, 上海 200336

  • 3.

    海军军医大学药学院, 上海 200433;浙江中医药大学药学院, 浙江 杭州 310053

基金项目: 国家自然科学基金资助项目（U1505226，U1603283）

Research progress in anti-osteoporosis effects of the herbs tonifying kidney-yang and kidney-yin

  • 1.

    School of Pharmacy, Naval Medical University, Shanghai 200433, China

  • 2.

    Shanghai Municipal Disease Control and Prevention, Shanghai 200336, China

  • 3.

    School of Pharmacy, Naval Medical University, Shanghai 200433, China;School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China

  • 摘要: 骨质疏松症是一种由多因素引起的骨密度和骨质量降低的全身性骨病，其破坏性之大、受众面之广已严重危害人类身心健康。目前，临床上治疗骨质疏松的药物，如双磷酸盐类、雌激素类等多具有潜在的副作用，而传统中药因其安全、有效且副作用小的特点已逐渐成为治疗骨质疏松症的补充和替代药物。中医认为"肾主骨"，肾虚则骨萎，因此采用补肾中药治疗骨质疏松症更是获得越来越多国内外学者的认可。补肾中药依据其作用效果的不同又分为补肾阳中药和补肾阴中药。对近年来补肾阳和补肾阴中药治疗骨质疏松症的作用及机制进行综述，旨在探索二者在治疗特点上的异同，为补肾中药抗骨质疏松的发展提供借鉴。
    Abstract: Osteoporosis (OP) is a systemic osteopathy with low bone mineral density and bone quality.It seriously endangered human physical and mental health due to its destructive and widespread characteristics.In clinic,drugs for OP,such as bisphosphonates and estrogens,have potential side effects.Contrarily,traditional Chinese medicine (TCM) has less adverse reactions and significant therapeutic effects.It becomes one of the remarkable complementary and alternative OP therapies.According to TCM theory,kidney is in charge of bone.The bone loss is attributed to the deficiencies of kidney.Therefore,herbs tonifying kidney had been used in the treatment of OP.Based on the different effects,herbs tonifying kidney are divided into tonifying kidney-yang and kidney-yin herbs.This paper reviews the effects and mechanisms of the herbs tonifying kidney-yang and kidney-yin in the OP treatment with the intention of exploring the similarities and differences of their treatment characteristics and providing reference for the development of kidney tonifying herbs in OP prevention and therapy.
  • [1] 沈皆亮,郝杰.骨质疏松治疗药物研究进展——新靶点,新药物[J].中国骨质疏松杂志,2014,20(7):844-848.
    [2] SHU B,SHI Q,WANG Y J.Shen (Kidney)-tonifying principle for primary osteoporosis:to treat both the disease and the Chinese medicine syndrome[J].Chin J Integr Med,2015,21(9):656-661.
    [3] ZHOU X H,CHEN B,XIE Y M,et al.Variable selection using the optimal ROC curve:an application to a traditional Chinese medicine study on osteoporosis disease[J].Stat Med,2012,31(7):628-635.
    [4] TOMAT A,GAMBA C A,MANDALUNIS P,et al.Changes in bone volume and bone resorption by olpadronate treatment in an experimental model of uremic bone disease[J].J Musculoskelet Neuronal Interact,2005,5(2):174-181.
    [5] BIAN Q,HUANG J H,YANG Z,et al.Effects of active ingredients in three kidney-tonifying Chinese herbal drugs on gene expression profile of bone marrow stromal cells from a rat model of corticosterone-induced osteoporosis[J].Zhong Xi Yi Jie He Xue Bao,2011,9(2):179-185.
    [6] 李姣,汤贤春,程小玲,等.BMP-2与Wnt/β-catenin信号通路对间充质干细胞分化为成骨细胞的作用[J].江苏医药,2017,43(23):1665-1670.
    [7] 屈晓龙,蒋涛.OPG-RANKL-RANK信号系统与骨质疏松治疗的研究进展[J].生命科学,2018,30(7):784-789.
    [8] 赵东峰,邢秋娟,王晶,等.骨稳态中成骨细胞与破骨细胞的阴阳属性[J].上海中医药杂志,2015,49(4):5-10.
    [9] 夏炳江,童培建,孙燕,等.骨质疏松肾阴虚型小鼠病证结合模型建立的实验研究[J].中国中医急症,2013,22(7):1083-1086.
    [10] 李媛,许红涛,李华强,等.肾阳虚骨质疏松大鼠动物模型的建立[J].药物评价研究,2015,38(2):135-139.
    [11] NAKAMURA T,IMAI Y,MATSUMOTO T,et al.Estrogen prevents bone loss via estrogen receptor alpha and induction of fas ligand in osteoclasts[J].Cell,2007,130(5):811-823.
    [12] SONG L,ZHAO J,ZHANG X,et al.Icarin induces osteoblast proliferation,differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation[J].Eur J Pharmacol,2013,714(1-3):15-22.
    [13] 李烨,肖亚平,李晶晶,等.淫羊藿对骨髓间充质干细胞影响的研究进展[J].中国药学杂志,2017,52(24):2137-2140.
    [14] 翟远坤,葛宝丰,马慧萍,等.淫羊藿苷促进体外培养大鼠骨髓间充质干细胞的成骨性分化[J].中国中药杂志,2010,35(23):3219-3222.
    [15] 吴国志,欧积壮,吴昌新.巴戟天水提取物对间充质干细胞成骨分化中OPG/RANKL表达的影响[J].海南医学,2016,27(3):345-347.
    [16] ZHANG Z G,ZHANG Q Y,YANG H,et al.Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice[J].Fitoterapia,2016,110:166-172.
    [17] ZHU M Y,WANG C J,ZHANG H S,et al.Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats[J].Int J Biol Macromol,2008,43(3):276-278.
    [18] ZHANG J H,XIN H L,XU Y M,et al.Morinda officinalis How.:a comprehensive review of traditional uses,phytochemistry and pharmacology[J].J Ethnopharmacol,2018,213:230-255.
    [19] 王琳琳,李薇,宋新波,等.肉从蓉中松果菊苷和毛蕊花糖苷的植物雌激素活性研究[J].天然产物研究与开发,2015,27(3):337-380.
    [20] 罗德梅,龙梅,杜文静,等.新疆肉苁蓉提取液对M-KOOPG小鼠抗骨质疏松的作用机制[J].中国实验方剂学杂志,2016,22(10):138-142.
    [21] REDLICH K,SMOLEN J S.Inflammatory bone loss:pathogenesis and therapeutic intervention[J].Nat Rev Drug Discov,2012,11(3):234-250.
    [22] 赖青海,王琳琳,丁辉,等.肉苁蓉治疗骨质疏松症研究进展[J].辽宁中医药大学学报,2016,18(3):102-104.
    [23] 明磊国,王鸣刚,陈克明,等.蛇床子素对体外培养破骨细胞骨吸收及细胞凋亡的影响[J].药学学报,2012,47(2):174-179.
    [24] 舒冰,李晓锋,唐德志,等.蛇床子素抑制破骨细胞生成防治5/6肾切除小鼠骨丢失的研究[C]//中国中西医结合学会.第二十一届全国中西医结合骨伤科学术研讨会暨骨伤科分会换届大会论文汇编.天津:中国中西医结合学会,2014:228-229.
    [25] MING L G,ZHOU J,CHENG G Z,et al.Osthol,a coumarin isolated from common cnidium fruit,enhances the differentiation and maturation of osteoblasts in vitro[J].Pharmacology,2011,88(1/2):33-43.
    [26] 孟繁浩.中药精选小复方骨疏丹促成骨细胞骨形成作用的研究[D].沈阳:沈阳药科大学,2004.
    [27] NIU Y,LI Y,HUANG H,et al.Asperosaponin VI,a saponin component from dipsacus asper wall,induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway[J].Phytother Res,2011,25(11):1700-1706.
    [28] 柴丽娟,王安红,徐金虎,等.补骨脂4种组分对LPS诱导的RAW264.7细胞炎症因子的影响[J].中药新药与临床药理,2013,24(4):360-362.
    [29] 王寅.仙茅苷抗骨质疏松作用及其机制的实验研究[D].北京:北京协和医学院,2011.
    [30] JEONG J C,KANG S K,YOUN C H,et al.Inhibition of Drynariae Rhizoma extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts[J].Int Immunopharmacol,2003,3(12):1685-1697.
    [31] 张乃丹.基于分子对接策略的熟地黄防治糖尿病性骨质疏松症有效成分及其作用机制研究[D].上海:第二军医大学,2016.
    [32] LIU C,MA R,WANG L,et al.Rehmanniae Radix in osteoporosis:A review of traditional Chinese medicinal uses,phytochemistry,pharmacokinetics and pharmacology[J].J Ethnopharmacol,2017,198:351-362.
    [33] 谢丽华,陈娟,李生强,等.六味地黄丸对绝经后骨质疏松症肾阴虚证JAK/STAT信号通路基因的影响[J].中国骨质疏松杂志,2014,20(7):741-746.
    [34] ZHANG Y,DIAO T Y,WANG L,et al.Protective effects of water fraction of Fructus Ligustri Lucidi extract against hypercalciuria and trabecular bone deterioration in experimentally type 1 diabetic mice[J].J Ethnopharmacol,2014,158:239-245.
    [35] 陈楠,李晓莉,张岩.女贞子及其活性成分抗骨质疏松作用及途径研究进展[J].中国药理学通报,2018,34(8):1057-1060.
    [36] LYU Y,FENG X,ZHAO P,et al.Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats[J].J Bone Miner Metab,2014,32(6):616-626.
    [37] 陈少茹,邹丽宜,吴铁.何首乌防治骨质疏松症的研究进展[J].现代医药卫生,2011,27(22):3428-3431.
    [38] 张海啸,尹智炜,李芳芳,等.何首乌水提液对去卵巢大鼠骨组织的动态影响[J].中日友好医院学报,2006,20(4):217-221.
    [39] 董佳梓,鞠大宏,贾朝娟,等.桑寄生、枸杞子、桑椹对去卵巢大鼠骨质疏松症的治疗作用及其机理探讨[J].中国中医基础医学杂志,2010,16(6):483-486.
    [40] 何昌强.山茱萸总甙促骨质疏松大鼠骨代谢的TRPV5/TRPV6通道机制及补肾壮骨法的临床应用研究[D].广州:广州中医药大学,2015.
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  • 收稿日期:  2018-11-29
  • 修回日期:  2019-01-10

补肾阳与补肾阴中药抗骨质疏松作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.02.003
  • 1. 海军军医大学药学院, 上海 200433
  • 2. 上海市疾病预防中心, 上海 200336
  • 3. 海军军医大学药学院, 上海 200433;浙江中医药大学药学院, 浙江 杭州 310053
    • 基金项目:  国家自然科学基金资助项目（U1505226，U1603283）
  • 收稿日期: 2018-11-29
  • 修回日期: 2019-01-10

摘要: 骨质疏松症是一种由多因素引起的骨密度和骨质量降低的全身性骨病，其破坏性之大、受众面之广已严重危害人类身心健康。目前，临床上治疗骨质疏松的药物，如双磷酸盐类、雌激素类等多具有潜在的副作用，而传统中药因其安全、有效且副作用小的特点已逐渐成为治疗骨质疏松症的补充和替代药物。中医认为"肾主骨"，肾虚则骨萎，因此采用补肾中药治疗骨质疏松症更是获得越来越多国内外学者的认可。补肾中药依据其作用效果的不同又分为补肾阳中药和补肾阴中药。对近年来补肾阳和补肾阴中药治疗骨质疏松症的作用及机制进行综述，旨在探索二者在治疗特点上的异同，为补肾中药抗骨质疏松的发展提供借鉴。

English Abstract

夏天爽, 薛黎明, 张巧艳, 辛海量, 李睿旻, 秦路平. 补肾阳与补肾阴中药抗骨质疏松作用的研究进展[J]. 药学实践与服务, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
引用本文: 夏天爽, 薛黎明, 张巧艳, 辛海量, 李睿旻, 秦路平. 补肾阳与补肾阴中药抗骨质疏松作用的研究进展[J]. 药学实践与服务, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
shu
XIA Tianshuang, XUE Liming, ZHANG Qiaoyan, XIN Hailiang, LI Ruimin, QIN Luping. Research progress in anti-osteoporosis effects of the herbs tonifying kidney-yang and kidney-yin[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
Citation: XIA Tianshuang, XUE Liming, ZHANG Qiaoyan, XIN Hailiang, LI Ruimin, QIN Luping. Research progress in anti-osteoporosis effects of the herbs tonifying kidney-yang and kidney-yin[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 109-114,155. doi: 10.3969/j.issn.1006-0111.2019.02.003
shu

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