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脑缺血和再灌注损伤与防治机制的研究进展

吴金华,  马慧萍,  蒙萍,  贾正平

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文章导航 > 药学实践与服务  > 2014 >  32(6): 401-404,447
吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
引用本文: 吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
shu
WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
Citation: WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
shu

脑缺血和再灌注损伤与防治机制的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.001
  • 1.

    兰州军区兰州总医院, 甘肃 兰州 730050;兰州大学药学院, 甘肃 兰州 730000

  • 2.

    兰州军区兰州总医院, 甘肃 兰州 730050

基金项目: 国家科技部重大专项资助项目(2008ZXJ09014-010);甘肃省省自然科学研究基金计划项目(1107RJZA100);全军医药卫生科研基金课题(CLZ11JA06).

Mechanisms of damage and treatments of cerebral ischemia and reperfusion

  • 1.

    Lanzhou General Hospital, Lanzhou Region of PLA, Lanzhou 730050, China;School of Pharmacy, Lanzhou University, Lanzhou 730000, China

  • 2.

    Lanzhou General Hospital, Lanzhou Region of PLA, Lanzhou 730050, China

  • 摘要: 总结脑缺血和再灌注损伤的发生和防治机制的研究进展,展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2+超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na+和Ca2+内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。
    Abstract: To summarize the advances in mechanisms of damage and treatments of cerebral ischemia and reperfusion and forecasts future research directions.The existing achievements in literatures were summarized.Cerebral ischemia and reperfusion damage were related to inflammatory response, intracellular calcium overload, free radicals injury, release of excitatory amino acids and other factors. The treatments included reducing ischemia time, blocking glutamate receptors, free radical scavenging, inhibition of apoptosis, reducing inflammation, and promoting neuronal growth, etc. Multi-target treatment would be future directions in treatment of cerebral ischemia.
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脑缺血和再灌注损伤与防治机制的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.001
  • 1. 兰州军区兰州总医院, 甘肃 兰州 730050;兰州大学药学院, 甘肃 兰州 730000
  • 2. 兰州军区兰州总医院, 甘肃 兰州 730050
    • 基金项目:  国家科技部重大专项资助项目(2008ZXJ09014-010);甘肃省省自然科学研究基金计划项目(1107RJZA100);全军医药卫生科研基金课题(CLZ11JA06).
  • 收稿日期: 2013-06-07
  • 修回日期: 2013-12-20

摘要: 总结脑缺血和再灌注损伤的发生和防治机制的研究进展,展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2+超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na+和Ca2+内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。

English Abstract

吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
引用本文: 吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
shu
WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
Citation: WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
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