留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

微透析与液相色谱-质谱联用在药物分析中的应用

吕狄亚,  洪战英,  娄子洋,  曹岩,  董昕,  柴逸峰

downloadPDF
文章导航 > 药学实践与服务  > 2011 >  29(2): 93-96,119
吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
引用本文: 吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
shu
LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation: LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
shu

微透析与液相色谱-质谱联用在药物分析中的应用

  • 第二军医大学药学院,上海 200433

基金项目: 国家自然科学基金资助委员会资助项目(30873196);上海市科学技术委员会科研计划项目(09dZ1975100).

Application of micro-dialysis-LC/MS in pharmaceutical analysis

  • School of Pharmacy, Second Military Medical University ,Shanghai 200433, China

  • 摘要: 目的 综述微透析与液相色谱-质谱联用技术在药物体内化学成分分析中的研究进展。 方法 参阅近几年国内外相关文献,对微透析与液相色谱-质谱联用技术在药物体内内源性物质及外源性物质中的应用进行归纳与总结。 结果与结论 微透析与液相色谱-质谱联用作为一种新型的分析技术,具有快速简便、干扰少、前处理简单等优点。此项技术在体内药物分析中得到了迅速推广和应用,特别在药代动力学研究中显示出其独特的优势,具有十分广阔的应用前景。
    Abstract: Objective To review the micro-dialysis coupled with chromatographic technologies in pharmaceutical analysis in vivo. Methods The relevant literatures were collected to make a summary of microdialysis coupled with chromatography technology in pharmaceutical analysis in vivo. Results and Conclusions As a new sampling technology, microdialysis coupled with LC-MS had advantages of high sensitive, fast, simple, less interference, and no sample preparation. This technology had been rapidly promoted and applied, especially in the pharmacokinetic-pharmacodynamic studies which had broad application prospects.
  • [1] Bourne JA Intracerebral microdialysis: 30 years as a tool for the neuroscientist[J]. Clin Exp Pharmacol Physiol, 2003, 30(1-2): 16.
    [2] Holovics HJ, Anderson CR , Levine BS, et al. Investigation of drug delivery by iontophoresis in a surgical wound utilizing microdialysis[J]. Pharm Res, 2008, 25(8): 1762.
    [3] Kim A, Suecof LA, Sutherland CA,et al. In vivo microdialysis study of the penetration of daptomycin into soft tissues in diabetic versus healthy volunteers[J]. Antimicrob Agents Chemother, 2008, 52(11): 3941.
    [4] Bielecka Grzela S, Klimowicz A. Application of cutaneous microdialysis to evaluate metronidazole and its main metabolite concentrations in the skin after a single oral dose[J]. J Clin Pharm Ther, 2003, 28(6): 465.
    [5] Lanckmans K, Clinckers R, Van Eeckhaut A, et al. Use of microbore LC-MS/MS for the quantification of oxcarbazepine and its active metabolite in rat brain microdialysis samples[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 831(1-2): 205.
    [6] Mathy FX, Vroman B, Ntivunwa D,et al. On-line determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2003, 787(2): 323.
    [7] O'Brien KB, Esguerra M , Klug CT,et al. A high-throughput on-line microdialysis-capillary assay for D-serine[J]. Electrophoresis,2003, 24(7-8): 1227.
    [8] 郑 红. 微透析与现代分析技术联用的研究进展[J]. 国外医学:药学分册, 2005, 32(4): 275.
    [9] Richards DA, Silva MA, Murphy N, et al. Extracellular amino acid levels in the human liver during transplantation: a microdialysis study from donor to recipient[J]. Amino Acids, 2007, 33(3): 429.
    [10] Davies MI, Lunte CE. Simultaneous microdialysis sampling from multiple sites in the liver for the study of phenol metabolism[J]. Life Sci,1996, 59(12): 1001.
    [11] Gilinsky MA, Faibushevish AA , Lunte CE. Determination of myocardial norepinephrine in freely moving rats using in vivo microdialysis sampling and liquid chromatography with dual-electrode amperometric detection[J]. J Pharm Biomed Anal, 2001, 24(5-6): 929.
    [12] Price KE, Vandaveer SS, Lunte CE,et al. Tissue targeted metabonomics: metabolic profiling by microdialysis sampling and microcoil NMR[J]. J Pharm Biomed Anal, 2005, 38(5): 904.
    [13] Lin LC, Hung LC, Tsai TH. Determination of (-)-epigallocatechin gallate in rat blood by microdialysis coupled with liquid chromatography[J]. J Chromatogr A, 2004, 1032(1-2): 125.
    [14] Huang H, Zhang Y, Yang R,et al. Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci,2008, 874(1-2): 77.
    [15] Ward KW, Pollack GM. Use of intrauterine microdialysis to investigate methanol-induced alterations in uteroplacental blood flow[J]. Toxicol Appl Pharmacol,1996, 140(2): 203.
    [16] Woo KL, Lunte CE. The development of multiple probe microdialysis sampling in the stomach[J]. J Pharm Biomed Anal, 2008, 48(1): 20.
    [17] Woo KL, Lunte CE. The direct comparison of health and ulcerated stomach tissue: a multiple probe microdialysis sampling approach[J]. J Pharm Biomed Anal, 2008, 48(1): 85.
    [18] Zhu T, Cheung BW, Cartier LL, et al. Simultaneous intravenous and intramiddle-ear dosing to determine cefditoren influx and efflux clearances in middle ear fluid in freely moving chinchillas[J]. J Pharm Sci, 2003, 92(10): 1947.
    [19] Ault JM, Riley CM, Meltzer NM,et al. Dermal microdialysis sampling in vivo[J]. Pharm Res, 1994, 11(11): 1631.
    [20] Kottegoda S, Shaik I, Shippy SA. Demonstration of low flow push-pull perfusion[J]. J Neurosci Methods, 2002, 121(1): 93.
    [21] 朱 林. 微透析取样技术及其在药代动力学中的应用[J]. 国外医学:药学分册, 2002, 29(5): 296.
    [22] Huff JK, Davies MI. Microdialysis monitoring of methylphenidate in blood and brain correlated with changes in dopamine and rat activity[J]. J Pharm Biomed Anal,2002, 29(5): 767.
    [23] Brunner M, Derendorf H. Clinical microdialysis: Current applications and potential use in drug development[J]. TrAC Trends in Analytical Chemistry, 2006, 25(7): 674.
    [24] Benveniste H, Drejer J, Schousboe A,et al. Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat[J]. J Neurochem, 1987, 49(3): 729.
    [25] Jin G, Cheng Q, Feng J,et al. On-line microdialysis coupled to analytical systems[J]. J Chromatogr Sci, 2008, 46(3): 276.
    [26] Tseng WC, Yang MH, Chen TP, et al. Automated, continuous, and dynamic speciation of urinary arsenic in the bladder of living organisms using microdialysis sampling coupled on-line with high performance liquid chromatography and hydride generation atomic absorption spectrometry[J]. Analyst, 2002, 127(4): 560.
    [27] Yang CS, Tsai PJ, Chen WY, et al. On-line, continuous and automatic monitoring of extracellular malondialdehyde concentration in anesthetized rat brain cortex[J]. J Chromatogr B Biomed Sci Appl, 2001, 752(1): 33.
    [28] Hows ME, Organ AJ, Murray S,et al. High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates[J]. J Neurosci Methods, 2002, 121(1): 33.
    [29] Bito L, Davson H, Levin E, et al. The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog[J]. J Neurochem,1966, 13(11): 1057.
    [30] Zhang MY, Beyer CE. Measurement of neurotransmitters from extracellular fluid in brain by in vivo microdialysis and chromatography-mass spectrometry[J]. J Pharm Biomed Anal, 2006, 40(3): 492.
    [31] 赵先恩,索有瑞. 大鼠端脑中神经递质的荧光衍生化高效液相色谱质谱联用法研究[J]. 分析化学, 2008, 36(1): 12.
    [32] Ji C, Li W, Ren XD,et al. Diethylation labeling combined with UPLC/MS/MS for simultaneous determination of a panel of monoamine neurotransmitters in rat prefrontal cortex microdialysates[J]. Anal Chem, 2008, 80(23): 9195.
    [33] Zhang MY, Hughes ZA, Kerns EH, et al. Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples[J]. J Pharm Biomed Anal, 2007, 44(2): 586.
    [34] Qu Y, Aluisio L, Lord B,et al. Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex[J]. Pharmacol Biochem Behav, 2009, 92(3): 469.
    [35] Guo P, Wang X, Liu L,et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry[J]. J Pharm Biomed Anal, 2007, 43(5): 1789.
    [36] 马仁玲,周红华,于喜水,等. 苦参注射液生物碱类成分指纹图谱的研究[J]. 中国中药杂志, 2003, 28(9): 817.
    [37] 刘 梅,刘雪英,程建峰. 苦参碱的药理研究进展[J]. 中国中药杂志, 2003, 28(9): 801.
    [38] 陈亚飞,田颂九,孙曾培. 复方石韦片中生物碱的分离测定[J]. 药物分析杂志, 2002, 22(2): 94.
    [39] 祝德秋,施安国. 苦参素注射液的人体药动学[J]. 中国医院药学杂志, 2003, 23(1): 21.
    [40] 孟根达来,王 毅,贾福群. 反相离子对高效液相色谱法测定人血浆中苦参碱和氧化苦参碱[J]. 药物分析杂志, 2003, 23(6): 440.
    [41] Zheng H, Chen G, Shi L, et al. Determination of oxymatrine and its metabolite matrine in rat blood and dermal microdialysates by high throughput liquid chromatography/tandem mass spectrometry[J]. J Pharm Biomed Anal, 2009, 49(2): 427.
    [42] Ye G, Li YZ, Li YY,et al. SPE-HPLC method for the determination and pharmacokinetic studies on paeoniflorin in rat serum after oral administration of traditional Chinese medicinal preparation Guan-Xin-Er-Hao decoction[J]. J Pharm Biomed Anal, 2003, 33(3): 521.
    [43] Guo M, Su X, Kong L, et al. Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC[J]. Anal Chim Acta, 2006, 556(1): 183.
    [44] Su X, Kong L, Li X,et al. Screening and analysis of bioactive compounds with biofingerprinting chromatogram analysis of traditional Chinese medicines targeting DNA by microdialysis/HPLC[J]. J Chromatogr A, 2005, 1076(1-2): 118.
    [45] Li SL, Li P, Sheng LH,et al. Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines[J]. J Pharm Biomed Anal, 2006, 41(2): 576.
    [46] Wen XD, Qi LW, Chen J,et al. Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 852(1-2): 598.
    [47] 艾 华, 王广基, 顾 轶, 等. 超高效液相色谱在现代药代动力学中的应用[J]. 中国药科大学学报, 2007, 38(4): 294.
  • [1] 夏哲炜, 曾垣烨, 朱海菲, 李育, 陈啸飞.  核磁共振磷谱法测定磷酸氢钙咀嚼片中药物含量 . 药学实践与服务, 2024, 42(9): 399-401, 406. doi: 10.12206/j.issn.2097-2024.202404063
    [2] 迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛.  负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
    [3] 赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量.  中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
    [4] 舒飞, 孙蕊, 宋凯, 张元林, 闫家铭, 舒丽芯.  粉-液双室袋产品综合评估 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202312009
    [5] 张莲卿, 骆岩, 杨提, 姚佳晨, 李文艳.  基于FAERS数据库的艾塞那肽微球不良事件信号挖掘与研究 . 药学实践与服务, 2024, 42(10): 445-450. doi: 10.12206/j.issn.2097-2024.202403057
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3464
  • HTML全文浏览量:  413
  • PDF下载量:  249
  • 被引次数: 0
出版历程
  • 收稿日期:  2010-09-26
  • 修回日期:  2010-12-30

微透析与液相色谱-质谱联用在药物分析中的应用

  • 第二军医大学药学院,上海 200433
    • 基金项目:  国家自然科学基金资助委员会资助项目(30873196);上海市科学技术委员会科研计划项目(09dZ1975100).
  • 收稿日期: 2010-09-26
  • 修回日期: 2010-12-30

摘要: 目的 综述微透析与液相色谱-质谱联用技术在药物体内化学成分分析中的研究进展。 方法 参阅近几年国内外相关文献,对微透析与液相色谱-质谱联用技术在药物体内内源性物质及外源性物质中的应用进行归纳与总结。 结果与结论 微透析与液相色谱-质谱联用作为一种新型的分析技术,具有快速简便、干扰少、前处理简单等优点。此项技术在体内药物分析中得到了迅速推广和应用,特别在药代动力学研究中显示出其独特的优势,具有十分广阔的应用前景。

English Abstract

吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
引用本文: 吕狄亚, 洪战英, 娄子洋, 曹岩, 董昕, 柴逸峰. 微透析与液相色谱-质谱联用在药物分析中的应用[J]. 药学实践与服务, 2011, 29(2): 93-96,119.
shu
LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
Citation: LV Di-ya, HONG Zhan-ying, LOU Zi-yang, CAO Yan, DONG Xing, CHAI Yi-feng. Application of micro-dialysis-LC/MS in pharmaceutical analysis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 93-96,119.
shu

    全文HTML

参考文献 (47)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计