伊贝沙坦对慢性肾小球肾炎的肾脏保护作用
Protective effect of irbesartan on renal in chronic glomerulonephritis
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摘要: 目的 研究伊贝沙坦对慢性肾小球肾炎患者尿蛋白的影响。方法 78例慢性肾炎病人接受伊贝沙坦(150mg,qd)治疗12周,分别测定治疗前、治疗6周和12周的24h尿蛋白定量。结果 经过治疗后,24h尿蛋白定量有显著下降,由治疗前的1.86g分别降至1.46g(6周)、1.18g(12周),P<0.01;治疗12周后与治疗6周后比较亦有显著下降(P<0.01)。结论 伊贝沙坦能够降低慢性肾炎患者尿蛋白,对肾脏具有保护作用。Abstract: Objective To study the effect of irbesartan on decrease proteinuria excretion in chronic glomerulonephritis. Methods:78 cases of chronic glomerulonephritis have taken irbesartan tablets (150mg,qd) to treatment for 12 weeks, and all cases were examined the level of 24-hour-proteinuria before and after treatment 6 weeks,12 weeks. Results After treatment, the level of 24-hour-proteinuria was significantly decreased. The level of proteinuria decreased from 1.86g(before treatment) to 1.46g (after 6 weeks) and 1.18g (after 12 weeks),P<0.01,and the level in 12 weeks was much lower than in 6 weeks(P<0.01). Conclusion Irbesartan has significant effect on decrease proteinuria in chronic glomerulonephritis patients.
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Key words:
- irbesartan /
- chronic glomerulonephritis /
- proteinuria
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