留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

代谢组学在白血病中的研究进展

宋志强,  朱臻宇,  刘悦,  柴逸峰

downloadPDF
文章导航 > 药学实践与服务  > 2019 >  37(5): 385-389,399
宋志强, 朱臻宇, 刘悦, 柴逸峰. 代谢组学在白血病中的研究进展[J]. 药学实践与服务, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
引用本文: 宋志强, 朱臻宇, 刘悦, 柴逸峰. 代谢组学在白血病中的研究进展[J]. 药学实践与服务, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
shu
SONG Zhiqiang, ZHU Zhenyu, LIU Yue, CHAI Yifeng. Research progress of metabolomics in leukemia[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
Citation: SONG Zhiqiang, ZHU Zhenyu, LIU Yue, CHAI Yifeng. Research progress of metabolomics in leukemia[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
shu

代谢组学在白血病中的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.001

  • 海军军医大学药学院, 上海 200433

基金项目: 国家自然科学基金（81703674）

Research progress of metabolomics in leukemia

  • School of Pharmacy, Naval Medical University, Shanghai 200433, China

  • 摘要: 代谢组学是对生物系统（细胞、组织、器官、生命体）中所有内源性小分子代谢物进行定性和定量分析的一门新学科，通过研究代谢物和代谢通路改变与生理病理变化之间的规律，揭示疾病的代谢本质。白血病是一种常见的血液系统恶性肿瘤，它的发生发展与代谢密切相关，代谢组学发现的内源性小分子代谢物已经广泛应用于白血病的发病机制、诊断和药效机制研究并取得了显著进展。综述近年来代谢组学在白血病发病机制、诊断和药效机制方面的研究进展，以期为进一步研究提供参考。
    Abstract: Metabolomics is a new science to quantitatively or qualitatively analyze all the endogenous small molecule metabolites in biological system(cells,tissues,organs,living organisms),which reveals the metabolic nature of diseases by studying the laws between changes in metabolites and metabolic pathways and physiological and pathological changes.Leukemia is a common malignant tumor of the blood system,which occurrence and development are closely related to metabolism.Endogenous small molecule metabolites discovered by metabolomics had been widely used in the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia and made significant progress.The advances of metabolomics about the study of pathogenesis,diagnosis and pharmacodynamic mechanism of leukemia in recent years were reviewed in this paper in order to provide reference for further research.
  • [1] 徐超,任立红.代谢组学在白血病中的应用[J].医学综述,2018,24(7):1294-1298.
    [2] AMITAY E L,KEINAN-BOKER L.Breastfeeding and childhood leukemia incidence:a meta-analysis and systematic review[J].JAMA Pediatr,2015,169(6):e151025.
    [3] ONCIU M.Acute lymphoblastic leukemia[J].Hematol Oncol Clin North Am,2009,23(4):655-674.
    [4] HANAHAN D,WEINBERG R A.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.
    [5] TAI E W,WARD K C,BONAVENTURE A,et al.Survival among children diagnosed with acute lymphoblastic leukemia in the United States,by race and age,2001 to 2009:Findings from the CONCORD-2 study[J].Cancer,2017,123(Suppl 24):5178-5189.
    [6] JEMAL A,SIEGEL R,XU J,et al.Cancer statistics,2010[J].CA Cancer J Clin,2010,60(5):277-300.
    [7] DIAMANTI P,COX C V,MOPPETT J P,et al.Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia[J].Blood,2013,121(8):1384-1393.
    [8] PELKONEN O,TERRON A,HERNANDEZ A F,et al.Chemical exposure and infant leukaemia:development of an adverse outcome pathway (AOP) for aetiology and risk assessment research[J].Arch Toxicol,2017,91(8):2763-2780.
    [9] MARCOTTE E L,THOMOPOULOS T P,INFANTE——RIVARD C,et al.Caesarean delivery and risk of childhood leukaemia:a pooled analysis from the Childhood Leukemia International Consortium (CLIC)[J].Lancet Haematol,2016,3(4):e176-e185.
    [10] ZHANG M Y,LIU Y,LIU M,et al.UHPLC-QTOF/MS-based metabolomics investigation for the protective mechanism of Danshen in Alzheimer's disease cell model induced by Aβ1-42[J].Metabolomics,2019,15(2):13.
    [11] ZHANG H,ZHAO Y H,XIA Z X,et al.Metabolic profiles revealed anti-ischemia-reperfusion injury of Yangxinshi tablet in Rats[J].J Ethnopharmacol,2018,214:124-133.
    [12] ARMITAGE E G,SOUTHAM A D.Monitoring cancer prognosis,diagnosis and treatment efficacy using metabolomics and lipidomics[J].Metabolomics,2016,12:146.
    [13] DUARTE I F,DIAZ S O,GIL A M.NMR metabolomics of human blood and urine in disease research[J].J Pharm Biomed Anal,2014,93:17-26.
    [14] 刘悦,赵亮,李燕,等.肝细胞性肝癌代谢组学研究进展[J].药学实践杂志,2013,31(2):81-85.
    [15] IBARRA-GONZÁLEZ I,CRUZ-BAUTISTA I,BELLO-CHAVOLLA O Y,et al.Optimization of kidney dysfunction prediction in diabetic kidney disease using targeted metabolomics[J].Acta Diabetol,2018,55(11):1151-1161.
    [16] LE Y C,SHEN X Y,KANG H Y,et al.Accelerated,untargeted metabolomics analysis of cutaneous T-cell lymphoma reveals metabolic shifts in plasma and tumor adjacent skins of xenograft mice[J].J Mass Spectrom,2018,53(8):739.
    [17] XU J,LI J S,ZHANG R P,et al.Development of a metabolic pathway-based pseudo-targeted metabolomics method using liquid chromatography coupled with mass spectrometry[J].Talanta,2019,192:160-168.
    [18] AMBERG A,RIEFKE B,SCHLOTTERBECK G,et al.NMR and MSmethods for metabolomics[J].Methods Mol Biol,2017,1641:229-258.
    [19] PAPADIMITROPOULOS M P,VASILOPOULOU C G,MAGA-NTEVE C,et al.Untargeted GC-MS metabolomics[J].Methods Mol Biol,2018,1738:133-147.
    [20] LIU W J,SONG Q Q,CAO Y,et al.From 1H NMR-based non-targeted to LC-MS-based targeted metabolomics strategy for in-depth chemome comparisons among four Cistanche species[J].J Pharm Biomed Anal,2019,162:16-27.
    [21] RAMAUTAR R,SOMSEN G W,DE JONG G J.CE-MS for metabolomics:Developments and applications in the period 2014-2016[J].Electrophoresis,2017,38(1):190-202.
    [22] YAN M,XU G W.Current and future perspectives of functional metabolomics in disease studies-A review[J].Anal Chim Acta,2018,1037:41-54.
    [23] LIU Y,LU S,ZHAO L,et al.Effects of glaucocalyxin A on human liver cancer cells as revealed by GC/MS- and LC/MS-based metabolic profiling[J].Anal Bioanal Chem,2018,410(14):3325-3335.
    [24] WU Q,ZHANG H,DING J R,et al.UPLC-QTOF MS——based serum metabolomic profiling analysis reveals the molecular perturbations underlying uremic pruritus[J].Biomed Res Int,2018,2018:4351674.
    [25] MAYER R L,SCHWARZMEIER J D,GERNER M C,et al.Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia[J].Mol Cell Proteomics,2018,17(2):290-303.
    [26] ALTMAN B J,STINE Z E,DANG C V.From Krebs to clinic:glutamine metabolism to cancer therapy[J].Nat Rev Cancer,2016,16(11):749.
    [27] AGATHOCLEOUS M,MEACHAM C E,BURGESS R J,et al.Ascorbate regulates haematopoietic stem cell function and leukaemogenesis[J].Nature,2017,549(7673):476-481.
    [28] OTTO A M.Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism[J].Cancer Metab,2016,4:5.
    [29] VANDER HEIDEN M G,CANTLEY L C,THOMPSON C B.Understanding the Warburg effect:the metabolic requirements of cell proliferation[J].Science,2009,324(5930):1029-1033.
    [30] MUSHARRAF S G,SIDDIQUI A J,SHAMSI T,et al.SERUM metabolomics of acute lymphoblastic leukaemia and acute myeloid leukaemia for probing biomarker molecules[J].Hematol Oncol,2017,35(4):769-777.
    [31] GUO D M,LIU Q Q,LI B B,et al.Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21:A case report[J].Oncol Lett,2014,7(2):565-567.
    [32] YANG B Y,LI X L,YAO Y,et al.Metabolomics ofchronic myelogenous leukemia based on GC-MS[J].Zhongguo Shi Yan Xue Ye Xue Za Zhi,2017,25(6):1585-1591.
    [33] CHEN W L,WANG J H,ZHAO A H,et al.A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value[J].Blood,2014,124(10):1645-1654.
    [34] WANG Y H,ZHANG L M,CHEN W L,et al.Rapid diagnosis and prognosis of de novo acute myeloid leukemia by serum metabonomic analysis[J].J Proteome Res,2013,12(10):4393-4401.
    [35] ZHANG X L,YANG J,CHEN M J,et al.Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells[J].Oncotarget,2016,7(29):46557-46572.
    [36] PERNICOVA I,KORBONITS M.Metformin:mode of action and clinical implications for diabetes and cancer[J].Nat Rev Endocrinol,2014,10(3):143-156.
    [37] MILLER R A,BIRNBAUM M J.An energetic tale of AMPK-independent effects of metformin[J].J Clin Invest,2010,120(7):2267-2270.
    [38] SCOTLAND S,SALAND E,SKULI N,et al.Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells[J].Leukemia,2013,27(11):2129-2138.
    [39] KOOPAL C,MARAIS A D,WESTERINK J,et al.Effect of adding bezafibrate to standard lipid-lowering therapy on post-fat load lipid levels in patients with familial dysbetalipoproteinemia.A randomized placebo-controlled crossover trial[J].J Lipid Res,2017,58(11):2180-2187.
    [40] SOUTHAM A D,KHANIM F L,HAYDEN R E,et al.Drugredeployment to kill leukemia and lymphoma cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids[J].Cancer Res,2015,75(12):2530-2540.
    [41] STÄUBERT C,BHUIYAN H,LINDAHL A,et al.Rewired metabolism in drug-resistant leukemia cells:a metabolic switch hallmarked by reduced dependence on exogenous glutamine[J].J Biol Chem,2015,290(13):8348-8359.
  • [1] 刘丽艳, 余小翠, 孙传铎.  纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
    [2] 刘汝雄, 杨万镇, 涂杰, 盛春泉.  铁死亡调控蛋白GPX4的小分子抑制剂研究进展 . 药学实践与服务, 2024, 42(9): 375-378. doi: 10.12206/j.issn.2097-2024.202312075
    [3] 张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英.  二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
    [4] 宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅.  帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
    [5] 毛智毅, 王筱燕, 陈晓颖, 汤逸斐.  度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
    [6] 张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲.  新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
    [7] 岳春华, 贲永光, 王海桥.  基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
    [8] 修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星.  全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
    [9] 姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量.  巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
    [10] 钱淑雨, 李铁军.  耐碳青霉烯类肠杆菌耐药机制的研究进展 . 药学实践与服务, 2024, 42(10): 419-425. doi: 10.12206/j.issn.2097-2024.202405005
    [11] 杨彬, 王作君, 陈菡, 张敬一.  基于DRGs的医院合理用药管理机制探索实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404030
    [12] 李清, 郭宜银, 陈颖, 瞿发林, 董文燊, 戈煜.  夜宁胶囊对小鼠镇静催眠作用及其机制的研究 . 药学实践与服务, 2024, 42(8): 346-349. doi: 10.12206/j.issn.2097-2024.202211047
    [13] 陈金涛, 乔子婴, 马明华, 张若曦, 王振伟, 年华.  基于网络药理学和分子对接技术研究金芪清疏颗粒治疗社区获得性肺炎的潜在机制 . 药学实践与服务, 2024, 42(11): 471-478. doi: 10.12206/j.issn.2097-2024.202312014
    [14] 何静, 安晔, 张朝绅.  复方黑参滴丸与复方黑参丸药效学实验比较研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404009
    [15] 杨嘉宁, 赵一颖, 肖伟.  七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
    [16] 徐飞, 陈瑾, 鲁育含, 李志勇.  肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
    [17] 景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞.  黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
    [18] 陈莹, 许子华, 胡北, 崔亚玲, 高欢, 吴琼.  通便灵胶囊治疗便秘的药效与机制研究 . 药学实践与服务, 2024, 42(): 1-7. doi: 10.12206/j.issn.2097-2024.202404008
    [19] 孙丹倪, 黄勇, 张嘉宝, 王培.  代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
    [20] 陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾.  基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 479-486. doi: 10.12206/j.issn.2097-2024.202401073
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3756
  • HTML全文浏览量:  432
  • PDF下载量:  383
  • 被引次数: 0
出版历程
  • 收稿日期:  2019-01-12
  • 修回日期:  2019-06-21

代谢组学在白血病中的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.001
  • 海军军医大学药学院, 上海 200433
    • 基金项目:  国家自然科学基金（81703674）
  • 收稿日期: 2019-01-12
  • 修回日期: 2019-06-21

摘要: 代谢组学是对生物系统（细胞、组织、器官、生命体）中所有内源性小分子代谢物进行定性和定量分析的一门新学科，通过研究代谢物和代谢通路改变与生理病理变化之间的规律，揭示疾病的代谢本质。白血病是一种常见的血液系统恶性肿瘤，它的发生发展与代谢密切相关，代谢组学发现的内源性小分子代谢物已经广泛应用于白血病的发病机制、诊断和药效机制研究并取得了显著进展。综述近年来代谢组学在白血病发病机制、诊断和药效机制方面的研究进展，以期为进一步研究提供参考。

English Abstract

宋志强, 朱臻宇, 刘悦, 柴逸峰. 代谢组学在白血病中的研究进展[J]. 药学实践与服务, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
引用本文: 宋志强, 朱臻宇, 刘悦, 柴逸峰. 代谢组学在白血病中的研究进展[J]. 药学实践与服务, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
shu
SONG Zhiqiang, ZHU Zhenyu, LIU Yue, CHAI Yifeng. Research progress of metabolomics in leukemia[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
Citation: SONG Zhiqiang, ZHU Zhenyu, LIU Yue, CHAI Yifeng. Research progress of metabolomics in leukemia[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 385-389,399. doi: 10.3969/j.issn.1006-0111.2019.05.001
shu

    全文HTML

参考文献 (41)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计