伏立康唑血药浓度监测结果评析

颜苗; 王柠柠; 李紫薇; 蒋梦飞; 王峰; 张毕奎; 徐萍; 肖轶雯

doi:10.3969/j.issn.1006-0111.2016.05.010

伏立康唑血药浓度监测结果评析

doi: 10.3969/j.issn.1006-0111.2016.05.010

1.
中南大学湘雅二医院药学部, 湖南长沙 410011;中南大学临床药学研究所, 湖南长沙 410011
2.
中南大学湘雅二医院药学部, 湖南长沙 410011;中南大学药学院, 湖南长沙 410208
3.
中南大学湘雅二医院药学部, 湖南长沙 410011

The evaluation and analysis on the results of voriconazole plasma concentration monitoring

1.
The Second Xiangya Hospital of Central South University, Changsha 410011, China;Institute of Clinical Pharmacy, Central South University, Changsha 410011, China
2.
The Second Xiangya Hospital of Central South University, Changsha 410011, China;School of Pharmaceutical Sciences of Central South University, Changsha 410208, China
3.
The Second Xiangya Hospital of Central South University, Changsha 410011, China

摘要: 目的通过对不同临床专科伏立康唑进行治疗药物监测（TDM），并比较调整剂量前后的血药谷浓度数据，阐明TDM对伏立康唑合理用药的必要性，并给出相关的临床提示。方法本研究通过回顾性分析伏立康唑TDM的数据，对收治入院的154位患者的435例次伏立康唑血药谷浓度测定结果做一个初期评估。结果肾移植科仅有4.3%的测定结果高于5.5 μg/ml，而有26.5%的测定结果低于1.0 μg/ml。感染科有52.3%的测定结果高于5.5 μg/ml，没有出现低于1.0 μg/ml的测定结果。结论 TDM对伏立康唑的合理用药十分必要，肾移植科患者伏立康唑TDM不在建议浓度区间的结果以低于1.0 μg/ml居多，而感染科患者则以高于5.5 μg/ml居多，临床上应予以重视。临床药师可根据TDM结果更密切地参与伏立康唑的临床用药。
- 伏立康唑 /
- 治疗药物监测 /
- 肾移植科 /
- 感染科
Abstract: Objective To clarify the necessity of therapeutic drug monitoring (TDM) of voriconazole, and give relevant clinical tips, by comparing the plasma concentration of different clinical specialties before and after adjustment of dose. Methods This is a retrospective study of voriconazole TDM data. It involves 435 cases voriconazole plasma trough concentration measurement results of 154 inpatients to make a preliminary assessment. Results 4.3% plasma concentration were higher than 5.5 μg/ml, 26.5% plasma concentration were less than 1.0 μg/ml in renal transplantation department; while 52.3% plasma concentration were higher than 5.5 μg/ml, no less than 1.0 μg/ml in infectious disease department. Conclusions Therapeutic drug monitoring is necessary for rational use of voriconazole. The majority of plasma concentrations in renal transplantation patients were <1.0 μg/ml, lower than recommended treatment concentration range; while most infectious disease patients have > 5.5 μg/ml, higher than recommended treatment concentration range. Clinical pharmacists can be more closely involved in the clinical use of voriconazole based on the results of the therapeutic drug monitoring.
- voriconazole /
- TDM /
- renal transplantation department /
- infectious disease department

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伏立康唑血药浓度监测结果评析

doi: 10.3969/j.issn.1006-0111.2016.05.010

The evaluation and analysis on the results of voriconazole plasma concentration monitoring

计量

伏立康唑血药浓度监测结果评析

doi: 10.3969/j.issn.1006-0111.2016.05.010

1. 中南大学湘雅二医院药学部, 湖南长沙 410011;中南大学临床药学研究所, 湖南长沙 410011

2. 中南大学湘雅二医院药学部, 湖南长沙 410011;中南大学药学院, 湖南长沙 410208

3. 中南大学湘雅二医院药学部, 湖南长沙 410011

English Abstract

The evaluation and analysis on the results of voriconazole plasma concentration monitoring

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目录

留言板

伏立康唑血药浓度监测结果评析

doi: 10.3969/j.issn.1006-0111.2016.05.010

The evaluation and analysis on the results of voriconazole plasma concentration monitoring

计量

出版历程

伏立康唑血药浓度监测结果评析

doi: 10.3969/j.issn.1006-0111.2016.05.010

1. 中南大学湘雅二医院药学部, 湖南 长沙 410011;中南大学临床药学研究所, 湖南 长沙 410011 2. 中南大学湘雅二医院药学部, 湖南 长沙 410011;中南大学药学院, 湖南 长沙 410208 3. 中南大学湘雅二医院药学部, 湖南 长沙 410011

English Abstract

The evaluation and analysis on the results of voriconazole plasma concentration monitoring

全文HTML

目录

1. 中南大学湘雅二医院药学部, 湖南长沙 410011;中南大学临床药学研究所, 湖南长沙 410011

2. 中南大学湘雅二医院药学部, 湖南长沙 410011;中南大学药学院, 湖南长沙 410208

3. 中南大学湘雅二医院药学部, 湖南长沙 410011