南海棘体海绵<i>Acanthella cavernosa</i>中的化学成分分析

范伟; 王旭东; 蔡海敏; 孙立光; 杨玲; 聂岁锋

doi:10.3969/j.issn.1006-0111.2016.02.011

南海棘体海绵Acanthella cavernosa中的化学成分分析

doi: 10.3969/j.issn.1006-0111.2016.02.011

解放军425医院, 海南三亚, 572008

基金项目: 海南省重点科技计划项目(ZDXM20110036);海南省自然科学基金(811223);海南省社会发展科技专项资金项目(SF201342);海南省卫生厅科学研究课题(琼卫-99-23)

Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

No.425 Hospital of PLA, Sanya 572000, China

摘要: 目的对中国南海棘体海绵(Acanthella cavernosa)的次生代谢产物进行研究。方法运用硅胶柱色谱、凝胶柱色谱、高效液相色谱等分离手段对棘体海绵的丙酮提取物进行分离纯化,根据现代波谱技术结合文献报道进行结构鉴定。结果共分离得到9个化合物,分别鉴定为kalihinol E(1)、kalihinol A(2)、10-epi-kalihinol X(3)、10-epi-kalihinol I(4)、1H-indole-3-carboxylic acid methyl ester(5)、1H-indole-3-carboxylic acid(6)、3-buten-2-one,4-(2,3,6-trimethylphenyl)-(3E)(7)、aristolone(8)、5α,8α-epidioxy-(22E,24R)-erost-6,22-dien-3β-ol(9)。结论化合物5~8首次从Acanthella属海绵中分离得到。
- 海绵 /
- 化学成分 /
- 结构鉴定
Abstract: Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was isolated and purified by repeated column chromatography on silica gel, sephadex LH-20, and high-performance liquid chromatography(HPLC). Structures were determined by spectroscopic analysis and comparison with reported data. Results Nine compounds were isolated. Their structures were determined as kalihinol E(1), kalihinol A(2), 10-epi-kalihinol X(3), 10-epi-kalihinol I(4), 1H-indole-3-carboxylic acid methyl ester(5), 1H-indole-3-carboxylic acid(6), 3-buten-2-one,4-(2,3,6-trimethylphenyl)-(3E)(7), aristolone(8), and 5α, 8α-epidioxy-(22E, 24R)-erost-6, 22-dien-3β-ol(9). Conclusion Compounds 5 to 8 were isolated from the sponge of genus Acanthalla for the first time.
- sponge /
- chemical constituents /
- structure identification

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南海棘体海绵Acanthella cavernosa中的化学成分分析

doi: 10.3969/j.issn.1006-0111.2016.02.011

Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

计量

南海棘体海绵Acanthella cavernosa中的化学成分分析

doi: 10.3969/j.issn.1006-0111.2016.02.011

解放军425医院, 海南三亚, 572008

English Abstract

Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

No.425 Hospital of PLA, Sanya 572000, China

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目录

留言板

南海棘体海绵Acanthella cavernosa中的化学成分分析

doi: 10.3969/j.issn.1006-0111.2016.02.011

Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

计量

出版历程

南海棘体海绵Acanthella cavernosa中的化学成分分析

doi: 10.3969/j.issn.1006-0111.2016.02.011

解放军425医院, 海南 三亚, 572008

English Abstract

Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

No.425 Hospital of PLA, Sanya 572000, China

全文HTML

目录

解放军425医院, 海南三亚, 572008