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纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展

陈自强,  张玮,  李玉平,  王晓宇

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文章导航 > 药学实践与服务  > 2016 >  34(2): 103-105
陈自强, 张玮, 李玉平, 王晓宇. 纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展[J]. 药学实践与服务, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
引用本文: 陈自强, 张玮, 李玉平, 王晓宇. 纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展[J]. 药学实践与服务, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
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CHEN Ziqiang, ZHANG Wei, LI Yuping, WANG Xiaoyu. Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
Citation: CHEN Ziqiang, ZHANG Wei, LI Yuping, WANG Xiaoyu. Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
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纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展

doi: 10.3969/j.issn.1006-0111.2016.02.002
  • 1.

    第二军医大学附属长海医院骨科, 上海 200433

  • 2.

    同济大学附属上海市肺科医院药剂科, 上海 200433

  • 3.

    第二军医大学附属长海医院药学部, 上海 200433

Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma

  • 1.

    Department of Orthopaedics, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433, China

  • 3.

    Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

  • 摘要: 多药耐药是肿瘤化疗中的重要难题,多药耐药的机制复杂,目前尚无有效的治疗策略。纳米载药系统具有靶向性、载药种类多样等优点,近年来成为对抗肿瘤多药耐药的递药载体的重要研究方向。对肿瘤抑制的不同机制进行讨论,并对纳米载药系统逆转骨肉瘤多药耐药的研究进展进行综述。
    Abstract: Multidrug resistance(MDR) of tumor cell is the major problem for chemotherapy. However, there is no effective strategy to overcome MDR due to the complicated mechanism. The nano-sized drug delivery system could target to the tumor cell. Moreover, it could delivery different kinds of drugs. Therefore, the nano-sized drug delivery system has become a promising approach to reverse MDR. The nano-sized drug delivery system which is applied to treat the MDR of tumor(osteosarcoma) was summarized and the reverse mechanism was discussed.
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    [10] Chen AM, Zhang M, Wei DG, et al. Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells[J]. Small, 2009, 5(23):2673-2677.
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  • 收稿日期:  2014-12-21
  • 修回日期:  2015-05-06

纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展

doi: 10.3969/j.issn.1006-0111.2016.02.002
  • 1. 第二军医大学附属长海医院骨科, 上海 200433
  • 2. 同济大学附属上海市肺科医院药剂科, 上海 200433
  • 3. 第二军医大学附属长海医院药学部, 上海 200433
  • 收稿日期: 2014-12-21
  • 修回日期: 2015-05-06

摘要: 多药耐药是肿瘤化疗中的重要难题,多药耐药的机制复杂,目前尚无有效的治疗策略。纳米载药系统具有靶向性、载药种类多样等优点,近年来成为对抗肿瘤多药耐药的递药载体的重要研究方向。对肿瘤抑制的不同机制进行讨论,并对纳米载药系统逆转骨肉瘤多药耐药的研究进展进行综述。

English Abstract

陈自强, 张玮, 李玉平, 王晓宇. 纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展[J]. 药学实践与服务, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
引用本文: 陈自强, 张玮, 李玉平, 王晓宇. 纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展[J]. 药学实践与服务, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
shu
CHEN Ziqiang, ZHANG Wei, LI Yuping, WANG Xiaoyu. Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
Citation: CHEN Ziqiang, ZHANG Wei, LI Yuping, WANG Xiaoyu. Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
shu

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